Yazar "Öztürk, Aykut" için listeleme
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Agomelatine reverses scopolamine-ınduced learning and memory impairment in adult rats
Saral, Sinan; Kaya, Ali Koray; Topçu, Atilla; Öztürk, Aykut; Sümer, Ayşegül; Pınarbaş, Esra (Sakarya Üniversitesi, 2021)Amaç: Agomelatin, melatonin reseptör (MT1 ve MT2) agonisti ve serotonin reseptör (5-HT2C) antagonisti olan antidepresan bir ilaçtır. Artan kanıtlar, agomelatinin nöroprotektif ve nöromodülatör etkiye sahip olduğunu ... -
Chronic restraint stress impairs spatial memory while decreasing hippocampal BDNF levels in rats
Saral, Sinan; Sümer, Ayşegül; Kaya, Ali Koray; Öztürk, Aykut; Topçu, Atilla (İnönü Üniversitesi Tıp Fakültesi, 2022)Aim: This study investigated the potential role of chronic restraint stress (CRS) on spatial memory, recognition memory, brain-derived neurotrophic factor (BDNF) and acetylcholine (ACh) levels in young adult rats. Material ... -
The effect of the calcium channel blocker nimodipine on hippocampal BDNF/Ach levels in rats with experimental cognitive impairment
Topçu, Atilla; Saral, Sinan; Öztürk, Aykut; Saral, Özlem; Kaya, Ali Koray (Taylor & Francis Ltd., 2023)Objective Alzheimer’s disease (AD) occurs in approximately 10% to 30% of individuals aged 65 or older worldwide. Novel therapeutic agents therefore need to be discovered in addition to traditional medications. Nimodipine ... -
The effects of amiodarone in ovarian injury due to oxidative stress and inflammation caused by ischemia-reperfusion
Topçu, Atilla; Öztürk, Aykut; Deniz, Esra; Öztürk, Seda Duman; Arpa, Medeni; Atak, Mehtap (Taylor & Francis Ltd., 2022)Objective Ovarian ischemia constitutes 2-3% of all gynecological emergencies. New-generation therapeutic agents need to be discovered, in addition to invasive interventions capable of reducing the risk of potential ovarian ... -
The effects of vitamin B12 on the TLR-4/NF-κB signaling pathway in ovarian ischemia-reperfusion injury-related inflammation
Deniz, Esra; Topçu, Atilla; Öztürk, Aykut; Öztürk, Seda Duman; Arpa, Medeni; Atak, Mehtap (Elsevier, 2022)Ovarian ischemia is a gynecological emergency case that occurs as a result of ovarian torsion. Oxidative stress and inflammation play central roles in the development of ischemia/reperfusion injuries. We investigated the ... -
Evaluation of endoplasmic reticulum stress in an experimental intestinal ischemia–reperfusion model in rats: the role of ozone therapy and trimetazidine
Demiral, Gökhan; Mercantepe, Tolga; Altuntaş, Gürkan; Pergel, Ahmet; Kalcan, Süleyman; Özdemir, Ali; Tümkaya, Levent; Mataracı Karakaş, Sibel; Öztürk, Aykut; Yılmaz, Adnan (MDPI, 2024)Aim: The objective of the study was to assess the impact of ozone (O3) and trimetazidine on the intestines following ischemia–reperfusion (I/R) injury through the investigation of endoplasmic reticulum stress. Methods: ... -
Geraniolun sıçanlarda anksiyete/depresyon benzeri davranış ve hipokampal kolinerjik sistem üzerine etkileri
Amaç: Kronik stresin depresyon benzeri davranışları arttırdığı bilinmektedir. Geraniol nöromodülatör ve antidepresan etkileri bilinen doğal bir monoterpendir. Bu çalışma, kronik kısıtlama stresi depresyon modeli sıçanlarda ... -
The protective effects of trimetazidine against ovary ischemia-reperfusion injury via the TLR4/Nf-kB signal pathway
Öztürk, Aykut; Topçu, Atilla; Deniz, Esra; Öztürk, Seda Duman; Arpa, Medeni; Yılmaz, Eda Kutlu (Wiley, 2022)Late diagnosis and treatment of ovarian ischemia can lead to worsening of ischemia, irreversible damage to ovarian functions and infertility. In this process, there is no approved medical treatment that can reduce the ...
