Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Which intracranial plane can be used instead of the true horizontal plane?
(Istanbul University Press, 2026) Gonca, Merve; Gül, Büşra Beşer; Kantemur, Zübeyde
The aim of this study was to evaluate the reliability of the Frankfort horizontal (FH), sella-nasion horizontal (SN-h), optic, and orbitooccipital planes by assessing their variabilities relative to a true horizontal line (TrH) in Class 1, 2, and 3 patients.
Efficacy and safety of direct-acting antivirals in patients with hepatitis c infection: nationwide real-life data from türkiye
(AVES, 2026) Gunduz, Alper; Öztoprak, Nefise Çuvalcı; Sarı, Nagehan Didem; Kurtaran, Behice; Önlen, Yusuf; Batırel, Ayşe; Tabak, Fehmi
Background/Aims: Chronic hepatitis C virus (HCV) infection constitutes a substantial healthcare concern in Türkiye. The clinical application of direct-acting antiviral medications (DAAs) has transformed its management. The goal is to assess the efficacy and safety of DAAs in the real-world setting in Turkish patients with chronic HCV. Materials and Methods: Thirty-seven centers from Türkiye recorded 1807 patients to the database. Patients aged >18 years were enrolled to the study. Their demographics, clinical information, DAAs used, efficacy, and safety information were evaluated. Efficacy and safety results were reported for patients with 12-week post-treatment (SVR12) data. Results: Among the patients, 919 (50.9%) were female with a mean of age 56 ± 15 years (range: 18-97 years) and 238 (13%) were cirrhotic. Liver biopsy was performed in 296 patients. Mean histologic activity index score was 7.68 and fibrosis score was 2.58. Baseline mean viral load was 4.11 × 10⁶ copies/mL. Patients received the following treatments: Paritaprevir+Ritonavir+Ombitasvir+Dasabuvir (PrOD): 706, Ledipasvir+Sofosbuvir: 490, Sofosbuvir+Ribavirin: 176, PrOD+Ribavirin: 175, Ledipasvir+Sofosbuvir+Ribavirin: 156, PrO+Ribavirin: 32, and PrO: 10. Response at the end of treatment was 99.2% (1454/1465) and SVR12 was 97.8% (1289/1318). The DAAs were generally well tolerated. Ten and 13 patients discontinued therapy because of drug-related and unrelated adverse side effects, respectively. Conclusion: This real-world study demonstrated that DAA treatment for HCV is both safe and highly effective. In two-thirds of the patients, the hepatic inflammation is moderate to severe, and fibrosis is moderate to advanced in half of them. Patients' characteristics suggest that HCV infection is often not diagnosed or treated until patients present with moderate-to-severe stage, indicating that diagnostic and therapeutic approaches should be used more effectively.
CRISPR/Cas9: An innovative biotechnological approach for the improvement of oilseeds
(CRC Press, 2026) Altaf, Muhammad Tanveer; Liaqat, Waqas; Jamil, Amna; Jan, Muhammad Faheem; Maqbool, Asia; Abbas, Naveed; Baloch, Faheem Shehzad
The growing demand for vegetable oils, driven by population growth, dietary shifts, and the need for sustainable resources, has highlighted challenges in oilseed production. Climate change, along with pest and disease pressures, has further complicated the production landscape. Traditional breeding techniques have made progress in improving oilseed traits, but are time-consuming and limited by unintended genetic traits. This chapter explores the transformative potential of CRISPR/Cas9 genome editing technology for oilseed improvement. With its precision and efficiency, CRISPR has enabled the enhancement of traits such as oil content, fatty acid composition, and resistance to environmental and biotic stresses. We discuss the advancements, challenges, and prospects of using CRISPR/Cas9 to develop oilseed crops that are resilient, high-yielding, and better suited to meet the global demand for sustainable vegetable oil production.
Revisiting the load capacity curve for sustainable development: the roles of plastic waste trade, digital trade, and biotrade in OECD countries
(Wiley, 2026) Pata, Uğur Korkut; Naimoğlu, Mustafa; Karlıer Pata, Selin
This study examines the validity of the Load Capacity Curve (LCC) hypothesis and assesses the environmental implications of emerging trade structures, focusing on BioTrade, digital trade, and plastic waste trade. Using a balanced panel of 36 OECD countries from 2011 to 2023, the analysis investigates how income dynamics and trade composition jointly influence the load capacity factor (LCF). Methodologically, the study employs the regularized Common Correlated Effects (rCCE) estimator and the Bias-Corrected Method of Moments (BCMM) approach. The empirical findings provide robust evidence supporting the LCC hypothesis, revealing a U-shaped relationship between income and LCF in OECD economies. Digital trade and BioTrade significantly enhance ecological capacity, reflecting the roles of technological diffusion, efficiency gains, and biodiversity-oriented economic activities. In contrast, plastic waste trade has a detrimental effect on LCF, highlighting the environmental risks associated with waste-driven trade flows. Based on these results, the study recommends that OECD countries strengthen digital and biodiversity-based trade channels while tightening regulations on plastic waste trade. Leveraging the LCC mechanism through sustainability-oriented trade policies can enable advanced economies to convert economic growth into long-term ecological resilience.
Trueness of complete arch intraoral implant scans using splinted and non-splinted scan bodies: A systematic review and meta-analysis
(Elsevier, 2026) Alawawda, Osayd; Yeşil, Zeynep; Sakarya, Rüştü Ersoy; Haoran, Mohammad Abo; Yeşil, Çağla
Statement of problem: Although splinting implant scan bodies has been proposed as a strategy to enhance the accuracy of complete arch intraoral implant scans, its effect on trueness has not been systematically investigated. Purpose: The purpose of this systematic review and meta-analysis was to evaluate the effect of splinted versus non-splinted implant scan body configurations on the trueness of complete arch intraoral implant scans. Material and methods: This systematic review and meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and structured according to the Participant, Intervention, Comparison, and Outcome (PICO) framework. Electronic searches were performed in the Web of Science, Scopus, and PubMed databases for studies published between January 2015 and December 2025. Quantitative outcomes related to trueness, including linear deviation, angular deviation, and root mean square (RMS) deviation, were extracted. Meta-analyses were performed using a random-effects model with standardized mean differences (SMDs) and 95% confidence intervals (CIs). Results: Eight studies were included in the meta-analysis. Splinting implant scan bodies demonstrated a statistically significant effect on trueness for linear deviation (SMD=0.49; 95% CI: 0.11 to 0.88; P=.016). No statistically significant differences were observed between splinted and non-splinted techniques for angular deviation or RMS deviation (P>.05). Moderate to high heterogeneity was identified across outcomes, and scanner-specific performance characteristics were found to contribute to variability among studies. Conclusions: Splinting implant scan bodies significantly improved trueness in terms of linear deviation for complete arch intraoral implant scans. However, no consistent benefits were observed for angular deviation or RMS deviation.
