Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
The effect of e-health literacy on kidney health awareness in adolescents: A cross-sectional study
(W.B. Saunders, 2026) Altay, Gamzegül; Büyük, Nisanur
Aim The aim of this study was to identify the factors associated with adolescents' e-health literacy and to evaluate e-health literacy as a predictor of kidney health awareness. Design and methods This study is descriptive and cross-sectional. The sample consisted of 669 high school students aged 14–18 years in three public high schools in northeastern Turkey. Data were collected using the “E-Health Literacy Scale in Adolescents” and the “Kidney Health Awareness Scale in Adolescents”. Simple linear regression and multiple linear regression methods were used to analyze the data. Results The mean score of the E -Health Scale was 28.25 ± 5.65 and the mean score of the Kidney Health Awareness Scale in Adolescents was 35.33 ± 7.34. Descriptive characteristics of adolescents (age, gender, mother and father education, income level), health perceptions and internet use accounted for 15.9% of the variance in e-health literacy. Statistical analysis indicated that e-health literacy was a significant predictor of kidney health awareness (β = 0.169, p < 0.001), where higher e-health literacy scores were associated with higher kidney health awareness scores. Conclusion E -health literacy was identified as a significant statistical predictor of kidney health awareness among adolescents. These findings suggest that higher levels of e-health literacy are associated with improved awareness of kidney health. Practice implications Nurses, schools and parents have important responsibilities in improving e-health literacy and kidney health awareness of adolescents. These findings contribute to preventive health services by highlighting the relationship between e-health literacy and kidney health awareness.
Water-soluble non-peripheral quinoline-substituted Co(II) and Cu(II) phthalocyanines as promising multi-target enzyme inhibitors: synthesis, enzyme kinetics, and molecular docking studies
(Elsevier, 2026) Keleş, Turgut; Akkaya, Didem; Özel, Arzu; Aksel, Ahmet Buğra; Eyi, Tuğba; Yıldırım, Beyza Nur; Bıyıklıoğlu, Zekeriya
New non-peripherally quinoline-substituted cobalt(II) and copper(II) phthalocyanines and their quaternized water-soluble derivatives were synthesized, characterized, and investigated as multi-target enzyme inhibitors. The synthesized compounds were structurally confirmed by FT-IR, UV–Vis, NMR, ESI-MS, and MALDI-TOF MS analyses. The water-soluble derivatives, n-8K-C3-CuQ and n-8K-C3-CoQ, were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and α-glucosidase. Both compounds showed stronger AChE inhibition than galantamine, with IC₅₀ values of 1.65 ± 0.58 µM for n-8K-C3-CuQ and 1.60 ± 0.94 µM for n-8K-C3-CoQ. In BuChE inhibition, n-8K-C3-CoQ exhibited the highest activity with an IC₅₀ value of 4.71 ± 1.96 µM, markedly superior to galantamine. Moreover, both derivatives displayed pronounced α-glucosidase inhibition, with IC₅₀ values of 1.14 ± 0.85 and 1.36 ± 0.49 µM for n-8K-C3-CuQ and n-8K-C3-CoQ, respectively, compared with acarbose. Enzyme kinetic studies revealed enzyme- and metal-dependent inhibition mechanisms, including competitive, mixed-type, and non-competitive inhibition modes. Molecular docking analyses supported the experimental findings, with favorable binding scores toward AChE, BuChE, and α-glucosidase, reaching -9.0 kcal/mol. Overall, these results suggest that water-soluble quinoline-functionalized metallophthalocyanines may represent promising scaffolds for the development of multi-target cholinesterase and α-glucosidase inhibitors. However, further cytotoxicity, selectivity, and in vivo studies are required before their therapeutic potential can be fully established.
Triazole-isatin hybrids as potential dual cholinesterase inhibitors for Alzheimer’s disease: synthesis, structure-activity relationships, molecular docking and in silico ADME profiling
(Elsevier, 2026) Yılmaz, Fatih; Akyüz, Gülay; Emirik, Mustafa; Çalışkan, Nedime; Menteşe, Emre
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and cholinesterase inhibition remains the principal strategy for its symptomatic treatment. Because BuChE progressively compensates for the loss of AChE activity as the disease advances, dual AChE/BuChE inhibitors continue to attract attention. Twenty-one new hybrid molecules (6–8a-g) were synthesised by reacting 4-amino-3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-ones (3a-g) with isatin-3-imine benzoyl chlorides (5a-c), and their structures were confirmed by 1H NMR and 13C NMR spectroscopy and corroborated by elemental analysis. Cholinesterase inhibition was measured by Ellman's method against galantamine. Twenty of the twenty-one derivatives inhibited AChE more strongly than galantamine (IC50 = 72.21 ± 0.87 µM), and thirteen of the fifteen hybrids for which BuChE IC50 could be quantified were also more potent than the reference. Compound 7 g was the most potent AChE inhibitor, while 7b gave the most potent BuChE inhibition and the best balance across the two enzymes (7b: AChE IC50 = 23.97 ± 0.22 µM; BuChE IC50 = 32.69 ± 0.44 µM; 7g: AChE IC₅₀ = 21.60 ± 0.28 µM), ahead of 8d (25.87 ± 0.10 µM). Structure-activity analysis identified the triazolone C-3 substituent as a major determinant of activity, with the isatin halogen modulating the magnitude of those substituent effects. Molecular docking provided a qualitative structural rationale for the experimental findings: 7b and 7g gave highly favourable AChE docking scores (−13.85 and −13.67 kcal mol⁻¹, respectively) with hydrogen-bonding and π-π stacking interactions, while 7b also scored more favourably than galantamine against BuChE (−8.75 versus −8.22 kcal mol⁻¹). In silico ADME profiling predicted high gastrointestinal absorption but poor blood-brain barrier permeation, and only the non-benzylic methyl and phenyl derivatives satisfied every druglikeness filter, with 7b combining full compliance with the best balanced AChE/BuChE inhibition profile.
Development of eco-friendly activated carbon from olive pits for the adsorption of tartrazine with isotherm kinetic and thermodynamic studies
(Nature Publishing Group, 2026) Remil, Abderrahmane; Reguig, Abdelkrim Bendoukha; Saidi, Mokhtar; Bouchama, Abdelghani; Monir, Mohammed El Amine; Fatmi, M.; Yaylacı, Murat
Synthetic dyes discharged into water bodies pose a persistent environmental threat owing to their resistance to natural degradation, toxicity, and long-term ecological impact. In this study, discarded olive pits were valorized as a lignocellulosic precursor for the production of activated carbon through phosphoric acid activation. Multiple analytical tools including pHpzc, FTIR, SEM, XPS, and XRD-were used to examine the structural, physicochemical, and morphological characteristics of the prepared material. The influence of key process variables on Tartrazine uptake was assessed through a series of batch-mode experiments, including pH, initial dye concentration, adsorbent dose, contact time, and temperature. Maximum adsorption was achieved in acidic medium (pH = 2) using an adsorbent dose of 40 mg, an initial Tartrazine concentration of 40 mg L-1, a contact time of 24 h, and a temperature of 298 K. The maximum adsorption capacity reached 47.18 mg g-1 according to the BET model, while the pseudo-second-order kinetic model provided the best fit (R2 = 0.9996) with an experimental Qe value of 31.39 mg g-1. Thermodynamic parameters (ΔH° = - 10328 J mol-1; ΔG° = - 1409 to - 1794 J mol-1) confirmed that the process is exothermic and spontaneous. The results of the pseudo-second-order kinetic model and Thermodynamic analysis showed that the process is a mixed adsorption mechanism dominated by physisorption. These findings collectively establish H3PO4-activated olive pit carbon as a high-performance, cost-effective, and environmentally viable material for Tartrazine decontamination from water matrices.
Effects of brewing conditions on the sensory and chemical properties of Turkish black tea and their interrelationships
(Nature Publishing Group, 2026) Cho, Jung Min; Yavuz Abanoz, Yasemin; Boyraz, Aslı; Demir, Adem; Çavuş, Derya; Çapoğlu, Havva Er; Başaran, Burhan
This study investigated the effects of different brewing conditions on the sensory and chemical properties of Turkish black tea and examined the relationships among the related parameters. The brewing variables evaluated were teapot type, brewing method, teapot spout condition, brewing time, and brewing water temperature. The brewed tea samples were evaluated by seven trained panelists for colour, astringency, and flavour and analysed for major chemical quality parameters, including total phenolic content (TPC), caffeine, theaflavins (TF), thearubigins (TR), brew colour indices, and L*a*b values. A total of 2,688 cups of brewed black tea were prepared, of which 672 were control and 2,016 were test samples, and were evaluated by seven trained panelists. Among the sensory attributes, colour was the most responsive parameter, being significantly affected by teapot type and brewing water temperature (p < 0.01), whereas astringency and flavour were not significantly influenced by the tested brewing conditions. In the chemical analyses, brewing water temperature was the most influential factor, significantly affecting TPC, caffeine, TF, TR, total colour in the brew, brightness in the brew, and a* (p < 0.01). Teapot type, brewing method, teapot spout condition, and brewing time also showed selective effects on specific chemical variables. Correlation analysis further showed that sensory colour was positively associated with TPC, caffeine, TF, TR, brightness in the brew, and total colour in the brew (p < 0.01), whereas astringency and flavour showed limited or no direct associations with the analysed chemical parameters. By examining Turkish-style brewing variables together with sensory and chemical profiling, this study provides novel evidence on sensory-chemical relationships in black tea and offers practical guidance for optimising brewing conditions in research and traditional tea preparation.
