Yazar "Aliyazıcıoğlu, Yüksel" için listeleme
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Alpha-pinene neutralizes cisplatin-induced reproductive toxicity in male rats through activation of Nrf2 pathway
Demir, Selim; Menteşe, Ahmet; Türkmen Usta, Zeynep; Türkmen Alemdar, Nihal; Ayazoğlu Demir, Elif; Aliyazıcıoğlu, Yüksel (Springer, 2023)Purpose Testicular toxicity is one of the most important side efects of cisplatin (CP) therapy. Alpha-pinene (AP) is a naturally occurring monoterpene with antioxidant character in plants. Here, we aimed to evaluate the ... -
The ameliorative effect of Primula vulgaris on cisplatin-induced nephrotoxicity in rats and quantification of its phenolic components using LC-ESI-MS/MS
Turan, İbrahim; Canbolat, Deniz; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Türkmen Alemdar, Nihal; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Cisplatin (CDDP) is an important chemotherapeutic agent, accumulation of which in kidney tissue causes nephrotoxicity and renal failure. The aim of this study was to evaluate, for the first time in the literature, the ... -
Antioxidant, antigenotoxic, antimicrobial activities and phytochemical analysis of dianthus carmelitarum
Aliyazıcıoğlu, Rezzan; Demir, Selim; Badem, Merve; Şener, Sıla Özlem; Korkmaz, Nuriye; Demir, Elif Ayazoğlu; Özgen, Ufuk; Karaoğlu, Şengül Alpay; Aliyazıcıoğlu, Yüksel (2017)In this study, we investigated the phytochemical composition, antioxidant, antimicrobial, and antigenotoxic properties of the aqueous extract of Dianthus carmelitarum for the first time. The phenolic and volatile compounds, ... -
Arbutin abrogates testicular ischemia/reperfusion injury in rats through repression of inflammation and ER stress
Demir, Elif Ayazoğlu; Demir, Selim; Kazaz, İlke Onur; Küçük, Hatice; Alemdar, Nihal Türkmen; Büyük, Ali; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)The aim of this study was to investigate the effects of arbutin (ARB) administration on oxidative stress, inflammation, endoplasmic reticulum (ER) stress and apoptosis in an experimental testicular torsion/detorsion ... -
Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats
Demir, Elif Ayazoğlu; Menteşe, Ahmet; Livaoğlu, Ayten; Alemdar, Nihal Türkmen; Aliyazıcıoğlu, Yüksel; Demir, Selim (Taylor & Francis Ltd., 2023)The aim of this study was to determine the possible therapeutic effect of chlorogenic acid (CGA) on cisplatin (CDDP)-induced ovarian damage in rats. Rats were first exposed to CDDP (5 mg/kg) and then treated CGA (1.5 and ... -
Ethyl pyruvate attenuates cisplatin-induced ovarian injury in rats via activating Nrf2 pathway
Demir, Selim; Menteşe, Ahmet; Küçük, Hatice; Yuluğ, Esin; Alemdar, Nihal Türkmen; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel (Taylor & Francis Ltd., 2023)Although cisplatin (CDDP) is an antineoplastic drug widely used for the treatment of various tumors, its toxicity on the reproductive system is a concern for patients. Ethyl pyruvate (EP) possesses potent antioxidant and ... -
Evaluation of the therapeutic effects of arbutin on cisplatin-induced ovarian toxicity in rats through endoplasmic reticulum stress and Nrf2 pathway
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Yılmaz, Zeynep Sağnak; Türkmen Alemdar, Nihal; Demir, Selim; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Arbutin (ARB) is a glycosylated hydroquinone with potent antioxidant effects. Although cisplatin (CP) is widely used in chemotherapy, its toxicity in healthy tissues, including ovotoxicity, is an insurmountable problem. ... -
Gallic acid attenuates torsion/detorsion-induced testicular injury in rats through suppressing of HMGB1/NF- κB axis and endoplasmic reticulum stress
Demir, Selim; Kazaz, İlke Onur; Kerimoğlu, Gökçen; Alemdar, Nihal Türkmen; Çolak, Fatih; Arıcı, Tuğba; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2024)It was aimed to evaluate whether gallic acid (GA) have a beneficial effect in the testicular ischemia/reperfusion injury (IRI) model in rats for the first time. Testicular malondialdehyde, 8-hydroxy-2 '-deoxyguanosine, ... -
Gentisic acid ameliorates cisplatin-induced reprotoxicity through suppressing endoplasmic reticulum stress and upregulating Nrf2 pathway
Menteşe, Ahmet; Demir, Selim; Aydın Mungan, Sevdegül; Alemdar, Nihal Türkmen; Ayazoğlu Demir, Elif; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Reproductive toxicity is a serious side effect of cisplatin (CP) chemotherapy. Gentisic acid (GTA) is a phenolic acid with strong antioxidant properties. Here, we aimed to determine therapeutic effect of GTA against ... -
Gentisic acid attenuates 5-fluorouracil-induced ovotoxicity in rats via modulating Nrf2 signalling: An experimental approach
Menteşe, Ahmet; Demir, Selim; Yuluğ, Esin; Küçük, Hatice; Alemdar, Nihal Türkmen; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel (Elsevier, 2024)5-Fluorouracil (5-FU) is the third most used chemotherapeutic in the world with its anticancer effect resulting from its potential to block DNA replication. Like other cytotoxic agents, 5-FU has side effects on healthy ... -
An investigation of the protective effect of rhododendron luteum extract on cisplatin-induced DNA damage and nephrotoxicity and biochemical parameters in rats
Turan, İbrahim; Canbolat, Deniz; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Alemdar, Nihal Türkmen; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (University of Agriculture, 2023)The nephrotoxicity mechanisms caused by cisplatin (CP), which is used in the treatment of different types of cancer, include several processes, such as DNA damage, apoptosis, inflammation, and oxidative stress. This study ... -
N-acetylcysteine ameliorates 5-fluorouracil-induced ovarian injury in rats
Demir, Elif Ayazoğlu; Menteşe, Ahmet; Küçük, Hatice; Alemdar, Nihal Türkmen; Demir, Selim; Aliyazıcıoğlu, Yüksel (Marmara Üniversitesi, 2023)Objective: Although 5-fluorouracil (5-FU) is one of the most commonly used chemotherapeutics worldwide, it has been shown that 5-FU administration can cause reproductive toxicity in recent years. N-acetylcysteine (NAC) is ... -
Suppression of cisplatin-induced ovarian injury in rats by chrysin: an experimental study
Menteşe, Ahmet; Türkmen Alemdar, Nihal; Livaoğlu, Ayten; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel; Demir, Selim (Taylor & Francis Ltd., 2022)The aim of this study was to investigate the potential therapeutic efficacy of chrysin (CHS) against ovotoxicity caused by intraperitoneal administration of cisplatin (CDDP) in rats. In this experimental study, 24 female ... -
Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands
Ayvaz, Melek Çol; Turan, İbrahim; Dural, Bayram; Demir, Selim; Karaoglu, Kaan; Aliyazıcıoğlu, Yüksel; Serbest, Kerim (Scientific Technical Research Council Turkey, 2017)Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) transition metal complexes of 2-hydroxy-5-[(E)-(4-phenyl) diazenyl] benzaldehyde oxime and 2-hydroxy-5-[(E)-(4-nitrophenyl) diazenyl] benzaldehyde oxime ligands were synthesized ... -
Syringic acid ameliorates ischemia/reperfusion-induced testicular injury in rats via suppressing of HMGB1/NF-kappa B axis and endoplasmic reticulum stress
Demir, Elif Ayazoğlu; Demir, Selim; Kazaz, İlke Onur; Küçük, Hatice; Alemdar, Nihal Türkmen; Geçici, Ömer Faruk; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Springer, 2023)PurposeTo investigate the possible protective role of syringic acid on torsion/detorsion-induced testicular injury using biochemical and histopathological approaches for the first time.MethodsA total of 24 rats were divided ... -
Therapeutic effect of astaxanthin on 5-fluorouracil-induced ovarian damage in rats
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Livaoğlu, Ayten; Alemdar, Nihal Türkmen; Demir, Selim; Aliyazıcıoğlu, Yüksel (Bilecik Şeyh Edebali Üniversitesi, 2024)Although astaxanthin (ASX) is one of the most studied antioxidant molecules, its curative effect against ovarian damage caused by 5-fluorouracil (5-FU) has not been demonstrated to date. It was therefore aimed to investigate ... -
Therapeutic effect of berberine against 5-fluorouracil induced ovarian toxicity in rats
Demir, Selim; Türkmen Alemdar, Nihal; Küçük, Hatice; Ayazoğlu Demir, Elif; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Taylor & Francis Ltd., 2024)Berberine (BER) is a naturally occurring alkaloid with a multitude of beneficial effects on human health. Although it is one of the most studied phytochemicals, its curative effect against ovarian damage caused by ... -
Usnic acid suppresses inflammation and endoplasmic reticulum stress in a methotrexate-induced pulmonary toxicity model via modulating Nrf2 pathway
Demir, Selim; Alemdar, Nihal Türkmen; Yuluğ, Esin; Demir, Elif Ayazoğlu; Durmuş, Tenzile Beyza; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2025)Pulmonary toxicity represents a significant adverse effect of methotrexate (MTX), characterised by increased oxidative stress (OS) and inflammation. This study focused on revealing the therapeutic role of usnic acid (UA) ... -
Vanillic acid abrogates cisplatin-induced ovotoxicity through activating Nrf2 pathway
Menteşe, Ahmet; Demir, Selim; Küçük, Hatice; Yuluğ, Esin; Alemdar, Nihal Türkmen; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Although cisplatin (CDDP) is an effective anticancer agent, the ovotoxicity that can occur in female patients limits its use. Oxidative stress (OS) and inflammation are known to contribute to CDDP-induced ovotoxicity. ...
