Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Comprehensive review of multiomics applications and remediation of plant heavy metal toxicity
(Springer Nature, 2025) Khan, Tamana; Shah, Labiba; Khan, Sabba; Wani, Owais Ali; Sheikh, Zahid Nabi; Afroza, Baseerat; Mansoor, Sheikh
Heavy metal pollution severely impacts plant health by inhibiting growth, photosynthesis, enzyme activities, and causing oxidative stress. Plants respond to such stress by activating complex defense mechanisms involving reactive oxygen species and different signaling pathways. These pathways are pivotal in triggering plant defense responses and are currently a major focus of research. Understanding the complex mechanisms of heavy metal uptake, transport, chelation, and signaling can guide strategies to improve plant resilience and stress tolerance. In this review, we aim to highlight the key heavy metals found in soil and the environment, along with their mechanisms of accumulation in plants. We also explore the defense responses of plants through various signaling pathways such as calcium (Ca2+), MAP kinase, and hormone signaling. Additionally, we emphasize the importance of understanding advanced omics technologies, including transcriptomics, metabolomics, and bioinformatic tools, in enhancing our knowledge of plant resilience and stress tolerance.
Recent advances in characterization and diagnosis of stone fruit tree viruses
(Springer, 2025) Wani, Sumiah; Iralu, Nulevino; Rashid, Shahjahan; Meghanath, Dasari; Shah, Mehraj ul Din; Nabi, Sajad un; Mansoor, Sheikh
Around seventy-five viruses have been reported to infect stone fruits which heavily reduce its yield and fruit quality, resulting in major economic losses. Viruses are very contagious and have devastating consequences on the host plants. In most of the stone fruit cultivars the viral infection is mostly symptomless and has the capability to infect a wide range of hosts. The most critical part of controlling these stone fruit viruses is proper diagnosis. Traditional approaches are regarded insufficient for identifying plant viruses due to less precision, and accuracy. To close the existing gap, researchers created specific, sensitive, and effective molecular techniques as a diagnostic tool for plant virus detection, which have the potential to improve disease management decision-making by overcoming several limitations of traditional methods. Due to the high risk of continuous spread of these viruses and for routine diagnosis to avoid further infection, management strategies must be incorporated. With the development of molecular techniques for viral disease identification and characterization, it became attainable to gain an enhanced and detailed understanding of their prevalence and genomic organization. This is an updated review on the viruses of stone fruits, their modes of transmission, genome organization, detection, and diagnosis.
Design, synthesis, and molecular docking of triazole-coumarin hybrids as potent breast cancer inhibitors targeting cell cycle and apoptosis
(John Wiley and Sons Inc, 2025) Keser, Murat; Menteşe, Emre; İlhan, Süleyman; Emirik, Mustafa; Atmaca, Harika
Breast cancer continues to pose a significant global health burden, highlighting the urgent need for novel chemotherapeutic agents with improved selectivity and reduced toxicity. In this study, we rationally designed and synthesized six novel amide-bridged triazole-coumarin hybrids (5a–f) based on the known anticancer potential of both pharmacophores. The synthesized compounds were evaluated for their cytotoxicity in MCF-7 and MDA─MB─231 breast cancer cell lines and non-tumorigenic MCF-10A cells. Among them, derivative 5f showed the most potent anticancer activity with minimal toxicity toward normal cells. Mechanistic studies revealed that 5f induced apoptosis by modulating Bax and Bcl─2 expression and arrested the cell cycle at the S phase via downregulation of CDK2 and Cyclin E. Molecular docking analyses confirmed its high binding affinity to CDK2 and Bcl─2, supporting its potential as a dual-target inhibitor. These findings suggest that compound 5f is a promising lead structure for the development of selective anticancer agents targeting breast cancer.
Ses verilerinin kuantum permütasyon pedi ile şifrelenmesi
(IEEE (Institute of Electrical and Electronics Engineers Inc.), 2025) Şanal, Burcu; Güler, Erkan; Kakız, M. Talha; Çavdar, Tuğrul
While the work of many scientists around the world continues rapidly to make quantum systems usable in real-life problems, simultaneously the power of quantum computers threatens information security in classical systems. It is expected that in the very near future, classical encryption methods will be completely inadequate in encrypting information. In our study, we used the encryption method "Quantum Permutation Pad"to ensure information security on audio data.
Barriers and facilitators to non-pharmacological management of metabolic dysfunction-associated steatotic liver disease: a qualitative evidence synthesis
(Frontiers Media SA, 2025) Yılmaz, Yusuf
Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a significant global health concern, with limited pharmacological options despite extensive research efforts. While the recent conditional approval of resmetirom for metabolic dysfunction-associated steatohepatitis with significant or advanced fibrosis has marked a major therapeutic milestone, lifestyle interventions–primarily dietary modifications and structured physical activity–remain the foundation of MASLD management for most patients. However, integrating these non-pharmacological strategies into routine clinical practice remains a significant challenge. In this qualitative evidence synthesis, we searched the PubMed, Scopus, ScienceDirect, and Google Scholar databases to identify and categorize the principal barriers and facilitators influencing the implementation of lifestyle interventions in MASLD care. The analysis identified 67 barriers and 64 facilitators. To address these multifaceted challenges, we propose a multidisciplinary management framework anchored in six core principles: (1) strategic integration of diverse professional expertise with clear role delineation; (2) patient-centered interventions that address both societal and individual barriers while leveraging facilitators; (3) early preventive measures to halt disease progression prior to the development of significant fibrosis; (4) tailored approaches responsive to disease severity and comorbidities; (5) optimized monitoring protocols with specific thresholds for intervention adjustment; and (6) judicious incorporation of digital health technologies, accounting for variability in digital literacy. We conclude that understanding both barriers and facilitators is essential for developing adaptable, patient-centered interventions. Our findings may provide a roadmap for addressing implementation challenges in non-pharmacological MASLD management, emphasizing the importance of preventive, tailored, multidisciplinary approaches that begin early and evolve with disease progression.
