Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Effect of dual-task interference on upper extremity motor experience with Parkinson’s disease motor effect of dual-task in Parkinson’s disease
(BioMed Central Ltd, 2025) Şenocak, Emre; Karaca, Seda; Aktürk, Adem
Objective: Humans use their motor and cognitive functions simultaneously while voluntarily performing real-time selective motor movements in daily life. This study aimed to investigate the effects of dual-task training on upper extremity motor skills and daily living activities in patients with Parkinson’s disease. Methods: The patients were randomized into two groups. One of the groups (Control) received a conventional physiotherapy program, while the other group (Dual-Task) also performed a cognitive-based dual-task intervention in addition to traditional rehabilitation. All rehabilitation programs were continued for 60 × 5 × 6 min/day/week. The assessments were performed twice: The two subsections of the MDS-Unified Parkinson’s Rating Scale (MDS-UPDRS II and III), Box Block Test (BBT), and Parkinson’s Disease Questionnaire-39 (PDQ-39). Results: There was no difference in any parameter between the groups, neither baseline nor after treatment (p > 0.05 for all). In the within-group assessments, the amount of change was higher in the MDS-UPDRS II and III sub-dimensions scores of the Dual-Task group. An increase was observed in the BBT results of both groups compared to pre-treatment (p < 0.05 for all). While the PDQ-39 score of the Dual-Task group improved by approximately 18% (p = 0.003), no change was detected in the control group (p = 0.413). Conclusion: Dual-task interference maintained throughout rehabilitation may enable the development of motor-cognitive functions required by individuals with Parkinson’s disease to perform daily living activities. For this reason, including dual-task training in rehabilitation to manage upper extremity impairment due to Parkinson’s disease may be helpful to maximize gains. Trial registration: This study was registered to clinicaltrials.gov with NCT06803212 ID (01.30.2025).
Bisphenol A and phthalate esters contamination in commercially available milk and dairy products in Türkiye: Packaging influence and health assessment
(Academic Press Inc., 2025) Başaran, Burhan; Olgun, Elmas Eva Öktem; Güzel, Barış; Türk, Merve; Canlı, Oltan
In this research, the levels of bisphenol A (BPA) and phthalate esters (PAEs) were determined in 54 distinct dairy products sold in Türkiye, which included ayran, yogurt, fruit yogurt, kefir, protein milk, children's milk, and milk. The study also evaluated the non-carcinogenic health risks associated with these products, focusing on the Target Hazard Quotient (THQ) and Hazard Index (HI). The average concentrations of BPA, bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), butylbenzyl phthalate (BBP), diethyl phthalate (DEP), di-n-octyl-phthalate (DNOP), and bis(2-ethylhexyl) terephthalate (BEHTP) in the analyzed dairy products were recorded as 1.18 ± 2.38, 0.36 ± 0.52, 0.05 ± 0.16, 1.13 ± 3.21, 0.01 ± 0.00, 1.37 ± 3.79, and 3.48 ± 11.00 µg/L, respectively. Tetra Pak samples showed lower average levels of BPA and PAEs than those in polypropylene (PP), polyethylene terephthalate (PET), and polystyrene (PS) packaging. The average exposure levels of BPA and ∑6PAEs in the examined milk and dairy products were found to be 0.23 ± 0.47 and 0.46 ± 1.31 µg/day, respectively. The calculated THQ and HI values for each compound, food group, and packaging type are significantly lower than the reference value of 1. However, it is noteworthy that a total of 29 samples (Samples 2–4, 7, 10, 11, 17–23, 26–31, 34, 35, 38–44, and 48) resulted in estimated intakes that exceeded the tolerable daily intake (TDI).
Mental energy paradigm for seafarers' wellbeing: A fuzzy Bayesian network model
(Elsevier, 2025) Öztürk, Orkun Burak; Kartal, Şaban Emre; Turna, İdris
The global maritime industry, which is responsible for over 80 % of world trade, is facing a critical challenge in the form of a decline in seafarers' mental health. The decline in the mental health of seafarers is driven by psychosocial stressors, such as feelings of isolation, fatigue, and substandard living conditions. This issue persists despite the introduction of frameworks such as the Maritime Labour Convention (MLC) 2006. A novel Fuzzy Bayesian Network (FBN) methodology, the first approach to assess seafarers' mental energy, fills a critical gap. The FBN model has identified that the predominant contributors of mental energy depletion were alcohol consumption (19.7 %), smoking (15.0 %), inadequate nutrition standards (14.8 %), a lack of recreational facilities (12.9 %), and physical unfitness (11.4 %), based on the contributions of multidisciplinary experts. The policy recommendations include the integration of mental energy management into training, the mandatory implementation of onboard wellness programs, the adoption of ergonomic ship designs, the revision of safe manning practices, and the enforcement of rest-hour compliance on high-traffic routes. According to the model, managerial interventions have the potential to enhance mental energy by a minimum of 59.4 %. This approach supports seafarer resilience, safeguarding individual well-being and global maritime operations, and pioneering mental health research for seafarers.
Avelumab maintenance in patients with metastatic urothelial carcinoma in a real-life expanded-access program
(Taylor and Francis Ltd., 2025) Tural, Deniz; Özkan, Oğuzcan; Mocan, Eda Eylemer; Kapar, Caner; Yaslıkaya, Şendağ; Aydın, Esra; Ürün, yüksel
Background This study evaluates the real-world efficacy and safety of avelumab maintenance therapy in patients with metastatic urothelial carcinoma (mUC) who did not progress following first-line platinum-based chemotherapy, using data from the Expanded Access Program (EAP). Patients and methods Safety and effectiveness were assessed in patients who received at least one cycle of avelumab. The primary endpoints were overall survival (OS) and progression-free survival (PFS), while secondary endpoints included safety. PFS and OS were estimated using the Kaplan-Meier method. Results The 12-month OS rate was 78% (95% CI, 74.5%-79%), with the median OS not reached. The 12-month PFS rate was 32% (95% CI, 29%-35%), and the median PFS was 5.3 months (95% CI, 3.4-7.1). Univariate analysis showed a median PFS of 2.9 months in patients with liver metastases versus 5.4 months in those without (p = 0.001), 2.8 months in patients with hemoglobin levels below 10 mg/dL versus 5.3 months in those above (p = 0.06), and 8.8 months in patients with lymph node - only metastases versus 4.1 months in patients with metastases at other sites (p = 0.05). No significant differences in PFS were observed based on chemotherapy type (cisplatin vs. carboplatin, p = 0.7), chemotherapy cycle count (<= 4 vs. > 4 cycles, p = 0.4), or first-line chemotherapy response (complete response vs. partial response/stable disease, p = 0.4). Conclusions Avelumab demonstrated efficacy and tolerability as maintenance therapy for mUC patients without progression following first-line platinum-based chemotherapy.
Two-dimensional piezoelectric nanomaterials for nanoelectronics and energy harvesting
(John Wiley and Sons Inc, 2025) Cao, Yujun; Aftab, Sikandar; Ali, Zeeshan; Khan, Muhammad Farooq; Nazir, Ghazanfar; Akman, Erdi; Li, Xin
Smart materials, especially piezoelectric materials, have gained popularity over the last two decades. Two-dimensional (2D) piezoelectric materials exhibit attributes including great flexibility, ease of workability, extensive surface area, and many active sites, indicating significant potential for future practical applications. However, 2D materials have bottlenecks such as poor stability against high-impact forces and unsatisfactory manufacturing techniques. This review examines cutting-edge research advancements on 2D piezoelectric materials and their applications in new-generation devices. First, the current review discusses the structure and working mechanism, synthesis methods, and characterization techniques of 2D piezoelectric materials. Then, a thorough review of the piezocatalysis technique is provided, analyzing the applications of 2D piezoelectric materials in various applications, including nanogenerators, nanosensors, field-effect transistors, photodetectors, and solar cells. In conclusion, the main obstacles and opportunities of 2D piezoelectric materials and their applications in the future are examined. We believe that this comprehensive review will make significant contributions to the qualitative and quantitative research of the production of commercial advanced functional devices and their large-scale integrated applications.
