Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Modeling and optimization of electro-mechanical properties in 18,650 batteries using a hybrid DNN-GWO approach: integrating metrological data and simulation
(Elsevier, 2026) Zhang, Qiang; Chang, Lei; Yaylacı, Murat; Awwad, Emad Mahrous; Telba, Ahmad A.
The process of optimizing lithium-ion batteries needs precise assessment of all their electro-mechanical and vibrational characteristics. The researchers present a measurement-based framework which enhances the performance of 18,650 lithium-ion cells that use graphene nanoplatelets as reinforcement material. A deep neural network (DNN) serves as the system that establishes complex connections between structural elements and their resulting performance metrics which include mechanical strength and electrical conductivity and vibrational response. The Grey Wolf Optimizer (GWO) establishes a structured approach to measurement space exploration which identifies the best system setups that achieve maximum battery capacity while maintaining dependable measurement results. The method focuses on three key aspects which include accurate measurement results and consistent measurement outcomes and methods of measuring uncertain results. The strong metrological framework establishes assessment procedures for evaluating performance improvements. The framework's ability to predict future outcomes gets confirmed through testing with separate experimental data from academic research while high-fidelity simulations show complete details about the electro-mechanical performance. The approach uses metrological principles which include accuracy and repeatability and uncertainty quantification to create a modeling and optimization system which trains the DNN using a hybrid dataset that combines experimental data with high-fidelity simulations and includes dedicated measurement noise simulation through explicit data augmentation. The measurement-guided approach achieves better results because it combines two advantages: improved accuracy and enhanced computational efficiency which surpass standard predictive and optimization methods. The research introduces an innovative measurement-based technique which uses artificial intelligence together with metrological standards to deliver precise battery performance evaluations and structured development of lithium-ion batteries.
Morphological structuring of Atlantic bonito (Scombridae: Sarda sarda) stocks in the southern Black Sea revealed by integrative phenotypic analyses
(0272-7714, 2026) Dürrani, Ömerhan; Bal, Habib; Erbay, Murat; Mazlum, Rahşan Evren; Türkoğlu, Muammer; Seyhan, Kadir
Atlantic bonito ( Sarda sarda ), a commercially important and highly migratory species, has long been managed as a single stock in the Black Sea and adjacent waters. This approach has historically been supported by genetic studies indicating widespread homogeneity. The present study provides an integrative phenotypic assessment of this assumption from a morphological perspective, incorporating: geometric morphometric analysis of body shape, traditional otolith shape indices, elliptical Fourier-based otolith shape analysis, and von Bertalanffy growth modelling. Specimens collected from the Eastern, Middle, and Western Black Sea (∼41–42°N) exhibited consistent morphological structuring, supporting the presence of at least two phenotypically differentiated stocks: one comprising the Eastern–Middle region and the other comprising the Western region. Traditional otolith shape indices failed to detect this structure, whereas elliptical Fourier analysis discriminated the Eastern–Middle phenotypic stock from the Western phenotypic stock. Growth modelling further supported phenotype-based stock differentiation, revealing significant differences in growth trajectories between the Western and Eastern–Middle phenotypic stocks, with no significant separation between the Eastern and Middle regions. This study also provides the first evidence of directional asymmetry in Atlantic bonito otoliths, a potential indicator of environmental stress. These findings advocate for a reassessment of single-stock management strategies and highlight the need for further investigation across broader regions, emphasising the value of integrative phenotypic assessment in identifying and refining management approaches for phenotypically differentiated stocks.
Triazole-substituted pyrazole–pyrimidine hybrids as anticancer agents: synthesis, cytotoxicity, apoptosis mechanisms, and JAB1-targeted structure-based design
(Academic Press Inc., 2026) Halac, Fatma Albayrak; Tulumcu, Zeynep Tugay; Kandemir, Büşra Nur Aydın; Altundas, Ramazan; Şahin, Kader; Tutar, Yusuf; Kulu, Irem
In this study, twelve new triazole substituted pyrazole-pyrimidine hybrid compounds were synthesized through click reaction and evaluated for their cytotoxic activity against pancreatic, breast, and gastric cancer cell lines. Among the tested compounds, 4e demonstrated the most potent cytotoxic activity, with IC₅₀ values below 10 μM across all evaluated cancer cell lines: Breast cancer cell lines MCF-7 (5.6 ± 1.01 μM), MDA-MB-231 (8.18 ± 1.26 μM), and gastric cancer cell line HGC-27 (5.68 ± 0.45 μM). Furthermore, RT-qPCR analysis revealed that 4e significantly modulated the expression of apoptosis-related genes, notably inducing a marked downregulation of BIRC3, implicating the activation of the mitochondria-mediated intrinsic apoptotic pathway. Flow cytometry confirmed apoptosis induction. Furthermore, computational metabolomic pathway analysis indicated that 4e altered glucose metabolism, notably affecting genes and metabolites associated with glycolysis and fatty acid biosynthesis. These results highlight compound 4e as a promising anticancer candidate with dual action on apoptotic signaling and metabolic pathways. Given the potent biological activity of 4e , further optimization was pursued through a structure-based drug design strategy targeting the oncogenic regulator JAB1, 4e was designed as a scaffold for targeting JAB1. A virtual library of analogues was generated, and all derivatives were docked against the JAB1 crystal structure (PDB ID: 5JOG). Several compounds showed higher docking scores than the co-crystallized ligand (CSN5i-3), suggesting enhanced binding affinity. In parallel, binary QSAR models were developed using the MetaCore/MetaDrug platform to predict anticancer activity. Based on the combined docking and QSAR analyses, several promising analogues were identified and proposed for synthesis and subsequent biological evaluation in future studies.
Bone health and fracture risk in diabetes: A multicenter study
(Springer, 2026) Gül, Özen Öz; Cantürk, Zeynep; Öztürk, Sadettin; Özdemir, Nilüfer; Candemir, Dilek Kılınç; Mercantepe, Filiz; Özkaya, Güven
Summary: We assessed bone health in over 2500 adults with diabetes across Türkiye. T1DM patients had lower BMD, while T2DM patients showed higher fracture risk despite higher BMD. Several modifiable factors were linked to osteoporosis. These findings support personalized bone assessments in diabetic populations. Background: Diabetes mellitus (DM) is a recognized risk factor for bone fragility. While type 1 DM (T1DM) is typically associated with low bone mineral density (BMD), type 2 DM (T2DM) often presents with higher BMD despite increased fracture risk. Large-scale comparative studies remain limited. Objective: To evaluate bone health, including osteopenia, osteoporosis, and fracture risk, in adults with T1DM and T2DM. Methods: This multicenter, cross-sectional study included 2562 patients (224 with T1DM, 2338 with T2DM) from 27 centers across Türkiye. BMD was assessed using dual-energy X-ray absorptiometry (DXA) and fracture risk was estimated via the Turkish-adapted FRAX® algorithm in patients aged ≥ 40 years. Multinomial logistic regression was used to identify independent predictors of low BMD. Results: Osteoporosis prevalence was 5.5% in T1DM and 9.6% in T2DM (femoral neck T-score). Adjusted BMD was significantly lower in T1DM at all skeletal sites, while FRAX-based fracture risk and fall-related fractures were higher in T2DM. Independent predictors of osteoporosis included older age, female sex, lower BMI, reduced calcium levels, corticosteroid use, albuminuria, hypertension, and less frequent sodium-glucose cotransporter-2 (SGLT2) inhibitor use. T1DM was independently associated with osteopenia but not osteoporosis. Conclusion: This multicenter study demonstrates distinct patterns of BMD and fracture risk across diabetes subtypes and supports individualized bone health assessment in routine diabetes care.
Rapid maxillary expansion related sutural and dentoalveolar changes provoke early-term oxidative stress
(BioMed Central Ltd, 2026) Köse, Tuba; Kiki, Ali; Köse, Oğuz; Türkeri, Özge Nur
Background: The management of oxidative stress-related cellular activity plays an important role in the bone healing process and dentoalveolar resorption. The aim of this study was to investigate the effects of rapid maxillary expansion on local and systemic oxidative stress levels. Methods: Thirty-five volunteer patients (17 females and 18 males) who needed rapid maxillary expansion were included in the study. Serum and unstimulated saliva samples were collected from each patient during four different periods: a week before the treatment (T0), the first day when sutural opening was detected clinically and radiographically (T1), the last day of the active expansion period (T2), and after the completion of a 3-month retention period (T3). To evaluate the patients’ periodontal status, plaque index, gingival index and probing pocket depth scores were recorded for each period. 8-hydroxydeoxyguanosine (8-OHdG), total oxidative status (TOS), total antioxidant status (TAS) and oxidative stress index (TOS/TAS: OSI) biomarkers were evaluated with ELISA and spectrophotometric methods to determine the local and systemic oxidative stress levels. Results: There were no statistically significant differences in the clinical periodontal parameters between the four measurement periods (p > 0.05). In the T1 period, only the salivary levels of the 8-OHdG (T1-T0; p:0.001, T2-T1; p:0.030, T3-T1; p:0.045), TOS (T1-T0; p < 0.001, T2-T1; p < 0.001, T3-T1; p < 0.001) and OSI (T1-T0; p < 0.001, T3-T1; p < 0.001) were statistically significantly higher when compared to the other periods. On the other hand, both the serum and salivary TAS levels there were not statistically significantly different between the periods (p > 0.05). Conclusion: Periodontal and skeletal changes associated with rapid maxillary expansion cause an increase in only salivary oxidative stress levels, especially during the initial sutural opening period (5–7 days). Trial registration: Clinical Trial Number is NCT06937775. It was recorded retrospectively (Record date 21/04/25).
