Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
A nanophytomedicine approach including tea tree essential oil for possible dental applications: in vitro and in silico evaluations
(Bentham Science Publishers, 2025) Budama Kılınç, Yasemin; Çakmakcı, Nisanur; Keçel Gündüz, Serda; Suyabatmaz, Şeyma; Karaoğlu, Şengül Apay; Yılmaz Atalı, Pınar; Kartal, Murat
Introduction: Tea tree essential oil (TTO) incorporated polylactic-co-glycolic acid (PLGA) nanoparticulate powder form was aimed to desined that can be applied with water and is effective against oral pathogens to prevent caries, and that is able to provide a long-lasting oral antiseptic effect. Methods: TTO-PLGA nanoparticles (TTO-NPs) was synthesized by single emulsion technique; average particle size, PdI value and zeta potential was measured by Zetasizer; TTO-PLGA interactions were investigated by FTIR, and morphological analysis was performed by TEM analysis. Phytoactive release and performans tests were carried out with in vitro dissolution and DNA binding-cleavage tests while antimicrobial performance was investigated by Ames-Salmonella assay, susceptibility test, in silico Molecular Docking and Molecular Dynamics studies. Results: TTO-NPs had an average particle size of 221.6 nm, a PdI of 0.103, and a zeta potential of -5.22 mV, 59.25% encapsulation efficiency and 25.65%. loading capacity. At the end of 5 h and 72 h the TTO release was 33.34±2.17% and 97.61±3.91% respectively. TTO-NPs were not mutagenic and were effective on investigated four cariogenic bacteria. The binding interactions of terpinen-4-ol, the main component of TTO, with Streptococcus mutans and Lactobacillus casei were revealed with enzyme-active-site-key residues. Discussion: In vitro and in silico studies confirmed that TTO-NPs were non-mutagenic and exhibited strong antimicrobial activity against dental caries-causing bacteria like Streptococcus mutans and Lactobacillus casei. Conclusion: In conclusion, TTO-NPs, which can be used as a mouthwash or powder, represent a promising solution for reducing oral pathogens, meriting further in vivo and clinical evaluations.
Growth hormone, insulin-like growth hormone-i axis, and bone fragility
(Springer Nature, 2026) Uygur, Meliha Melin; Acanfora, Matteo; Frara, Stefano; Giustina, Andrea
Growth hormone (GH) and insulin-like growth factor-I regulate skeletal physiology, and both excessive and deficient levels affect bone remodeling and alter bone microstructure. Bone quality is affected more than bone quantity, and vertebral fractures (VFs) are an early phenomenon of impaired bone health. Since fractures cannot be accurately predicted by areal bone mineral density, emerging data demonstrate that a morphometric approach is essential for evaluating bone health given their predictive role in both clinical settings. Several novel tools assessing bone quality and bone remodeling have been proposed as alternative or additional methods for the prediction of fractures. Prompt disease control of acromegaly and GH replacement therapy for GH deficiency (GHD) are fundamental for the restoration and maintenance of skeletal health. Replacement of other pituitary deficiencies, especially sex hormones, should be provided for advanced bone outcomes in patients with GHD with cautious replacement of glucocorticoids and levothyroxine to avoid overtreatment. Vitamin D has proved to be very effective in the prevention of VFs in the case of acromegaly and in improvement of bone microarchitecture when combined with GH replacement therapy in patients with GHD. The effectiveness of bone active drugs in the prevention of VFs in both clinical settings needs to be clarified.
Structure–activity relationships of morpholine-modified silicon(iv) phthalocyanines as potential antidiabetic agents
(Royal Society of Chemistry, 2026) Keleş, Turgut; Bıyıklıoğlu, Zekeriya; Seyhan, G.; Barut, Burak
Type 2 diabetes mellitus (DM) is a chronic metabolic disorder with a rapidly increasing global prevalence, highlighting the need for safer and more effective therapeutic strategies. In this study, a series of axially disubstituted silicon(iv) phthalocyanines bearing morpholine functional groups and their water-soluble derivatives were synthesized, structurally characterized, and evaluated for their antidiabetic potential. The synthesized compounds were characterized by FT-IR, 1H and 13C NMR, UV–Vis spectroscopy, and mass spectrometry. The in vitro antidiabetic activity of the compounds was evaluated through α-glycosidase and α-amylase inhibition assays. The non-ionic silicon(iv) phthalocyanine derivatives MT-C3-H-Si and MT-C3-D-Si exhibited strong α-glucosidase inhibitory activity with IC50 values of 16.02 ± 0.94 μM and 44.14 ± 4.06 μM, respectively, showing higher potency than the standard inhibitor acarbose (IC50 = 60.51 ± 4.66 μM). In contrast, the water-soluble derivatives MT-C3-H-SiQ and MT-C3-D-SiQ displayed lower inhibitory activity (IC50 = 68.80 ± 5.12 μM and >100 μM, respectively), indicating that increased hydrophilicity does not necessarily enhance enzyme inhibition. All compounds exhibited weak α-amylase inhibition (IC50 > 100 μM) compared with acarbose (IC50 = 25.29 ± 3.50 μM). Kinetic studies revealed that MT-C3-H-Si and MT-C3-D-Si inhibit α-glycosidase via a non-competitive mechanism, with Ki values of 9.45 ± 1.45 μM and 29.06 ± 5.16 μM, respectively. This is characterized by decreased Vmax values without significant changes in Km, suggesting interaction with allosteric regions of the enzyme. Overall, these findings highlight axially disubstituted silicon(iv) phthalocyanines as promising molecular scaffolds and contribute valuable insight into the limited literature on their antidiabetic enzyme inhibition properties.
Dispersion and damping characteristics of Rayleigh-type waves in KG nonlocal fractional piezo-thermo-electric semiconductor medium
(Emerald Publishing, 2026) Aldandani, Mohammed; Das, Soumik; Yadav, Arun Kumar; Yaylacı, Murat; Gupta, Vipin
Purpose – This study aims to investigate Rayleigh-type surface wave propagation in a piezo-thermo-electric semiconductor medium. Klein–Gordon-type nonlocal effects and a higher-order fractional three-phase-lag heat-conduction model are incorporated. The analysis examines how nonlocal elasticity, piezoelectric semiconducting behavior and advanced heat-conduction influence wave dispersion and attenuation. Design/methodology/approach – Analytical solutions are obtained using the wave-mode method. The Durand–Kerner algorithm is applied to solve the characteristic equation and identify physically admissible surface wave modes. The analysis is performed for a half-space under isothermal and electrically insulated boundary conditions. Fractional derivatives and multiple phase lags are included to account for advanced thermal transport effects. Findings – Numerical results show the variation in dispersion relations, phase velocity and attenuation with changes in spatial and temporal nonlocal parameters as well as phase lags. Surface particle trajectories are also evaluated. Sensitivity analysis highlights the distinct influence of higher-order thermal lags and nonlocal effects on wave propagation and energy dissipation. Research limitations/implications – This investigation addresses a key gap in the literature by simultaneously incorporating Klein–Gordon nonlocality, fractional effects, thermo-electro-mechanical coupling and three-phase lag behavior in semiconductor media. The study also presents several limiting and special cases. These results provide a basis for future work on coupled wave phenomena in advanced functional materials with microstructural effects. Practical implications – The outcomes support the development of smart surface devices, acoustic sensors and energy harvesting systems. The findings are relevant to applications in microelectronics, optoelectronics and seismic engineering. Originality/value – This paper develops a framework for Rayleigh wave analysis in piezo-semiconductor media with Klein–Gordon-type nonlocal elasticity and a higher-order fractional three-phase-lag thermal model.
Innovations in digital governance for enhanced accountability and sustainability
(Emerald Group Publishing Ltd., 2026) Naz, Aisha; Ali, Muhammad; Barut, Abdulkadir
This chapter, ‘Innovations in Digital Governance for Enhanced Accountability’, explores how emerging technologies are transforming public administration and enhancing governance accountability. It defines digital governance and its importance in modernizing public sector operations, emphasizing accountability as a core component. The chapter outlines the principles of e-governance transparency, efficiency, and accountability, and examines successful case studies from Estonia and India. The focus then shifts to emerging technologies such as blockchain, artificial intelligence (AI), and cloud computing. Blockchain is highlighted for its secure, tamper-proof records; AI for predictive analytics and fraud detection; and cloud computing for scalable, secure governance solutions. The integration of big data to enhance civic engagement is also discussed, along with the ethical and practical challenges these technologies pose. The chapter highlights the role of digital transparency and open data initiatives in improving public accountability, with case studies from Barcelona and New York City. It also addresses cybersecurity and data protection, stressing the need for robust defences and legal frameworks to protect sensitive information. Finally, the chapter explores the role of public–private partnerships in driving innovation and ensuring accountability, with case studies from Singapore and the United Kingdom. It concludes by discussing regulatory frameworks and future trends in digital governance, underlining the need for adaptable policies to address emerging challenges and ensure effective, transparent governance.
