Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Structure–activity relationships of morpholine-modified silicon(iv) phthalocyanines as potential antidiabetic agents
(Royal Society of Chemistry, 2026) Keleş, Turgut; Bıyıklıoğlu, Zekeriya; Seyhan, G.; Barut, Burak
Type 2 diabetes mellitus (DM) is a chronic metabolic disorder with a rapidly increasing global prevalence, highlighting the need for safer and more effective therapeutic strategies. In this study, a series of axially disubstituted silicon(iv) phthalocyanines bearing morpholine functional groups and their water-soluble derivatives were synthesized, structurally characterized, and evaluated for their antidiabetic potential. The synthesized compounds were characterized by FT-IR, 1H and 13C NMR, UV–Vis spectroscopy, and mass spectrometry. The in vitro antidiabetic activity of the compounds was evaluated through α-glycosidase and α-amylase inhibition assays. The non-ionic silicon(iv) phthalocyanine derivatives MT-C3-H-Si and MT-C3-D-Si exhibited strong α-glucosidase inhibitory activity with IC50 values of 16.02 ± 0.94 μM and 44.14 ± 4.06 μM, respectively, showing higher potency than the standard inhibitor acarbose (IC50 = 60.51 ± 4.66 μM). In contrast, the water-soluble derivatives MT-C3-H-SiQ and MT-C3-D-SiQ displayed lower inhibitory activity (IC50 = 68.80 ± 5.12 μM and >100 μM, respectively), indicating that increased hydrophilicity does not necessarily enhance enzyme inhibition. All compounds exhibited weak α-amylase inhibition (IC50 > 100 μM) compared with acarbose (IC50 = 25.29 ± 3.50 μM). Kinetic studies revealed that MT-C3-H-Si and MT-C3-D-Si inhibit α-glycosidase via a non-competitive mechanism, with Ki values of 9.45 ± 1.45 μM and 29.06 ± 5.16 μM, respectively. This is characterized by decreased Vmax values without significant changes in Km, suggesting interaction with allosteric regions of the enzyme. Overall, these findings highlight axially disubstituted silicon(iv) phthalocyanines as promising molecular scaffolds and contribute valuable insight into the limited literature on their antidiabetic enzyme inhibition properties.
Dispersion and damping characteristics of Rayleigh-type waves in KG nonlocal fractional piezo-thermo-electric semiconductor medium
(Emerald Publishing, 2026) Aldandani, Mohammed; Das, Soumik; Yadav, Arun Kumar; Yaylacı, Murat; Gupta, Vipin
Purpose – This study aims to investigate Rayleigh-type surface wave propagation in a piezo-thermo-electric semiconductor medium. Klein–Gordon-type nonlocal effects and a higher-order fractional three-phase-lag heat-conduction model are incorporated. The analysis examines how nonlocal elasticity, piezoelectric semiconducting behavior and advanced heat-conduction influence wave dispersion and attenuation. Design/methodology/approach – Analytical solutions are obtained using the wave-mode method. The Durand–Kerner algorithm is applied to solve the characteristic equation and identify physically admissible surface wave modes. The analysis is performed for a half-space under isothermal and electrically insulated boundary conditions. Fractional derivatives and multiple phase lags are included to account for advanced thermal transport effects. Findings – Numerical results show the variation in dispersion relations, phase velocity and attenuation with changes in spatial and temporal nonlocal parameters as well as phase lags. Surface particle trajectories are also evaluated. Sensitivity analysis highlights the distinct influence of higher-order thermal lags and nonlocal effects on wave propagation and energy dissipation. Research limitations/implications – This investigation addresses a key gap in the literature by simultaneously incorporating Klein–Gordon nonlocality, fractional effects, thermo-electro-mechanical coupling and three-phase lag behavior in semiconductor media. The study also presents several limiting and special cases. These results provide a basis for future work on coupled wave phenomena in advanced functional materials with microstructural effects. Practical implications – The outcomes support the development of smart surface devices, acoustic sensors and energy harvesting systems. The findings are relevant to applications in microelectronics, optoelectronics and seismic engineering. Originality/value – This paper develops a framework for Rayleigh wave analysis in piezo-semiconductor media with Klein–Gordon-type nonlocal elasticity and a higher-order fractional three-phase-lag thermal model.
Innovations in digital governance for enhanced accountability and sustainability
(Emerald Group Publishing Ltd., 2026) Naz, Aisha; Ali, Muhammad; Barut, Abdulkadir
This chapter, ‘Innovations in Digital Governance for Enhanced Accountability’, explores how emerging technologies are transforming public administration and enhancing governance accountability. It defines digital governance and its importance in modernizing public sector operations, emphasizing accountability as a core component. The chapter outlines the principles of e-governance transparency, efficiency, and accountability, and examines successful case studies from Estonia and India. The focus then shifts to emerging technologies such as blockchain, artificial intelligence (AI), and cloud computing. Blockchain is highlighted for its secure, tamper-proof records; AI for predictive analytics and fraud detection; and cloud computing for scalable, secure governance solutions. The integration of big data to enhance civic engagement is also discussed, along with the ethical and practical challenges these technologies pose. The chapter highlights the role of digital transparency and open data initiatives in improving public accountability, with case studies from Barcelona and New York City. It also addresses cybersecurity and data protection, stressing the need for robust defences and legal frameworks to protect sensitive information. Finally, the chapter explores the role of public–private partnerships in driving innovation and ensuring accountability, with case studies from Singapore and the United Kingdom. It concludes by discussing regulatory frameworks and future trends in digital governance, underlining the need for adaptable policies to address emerging challenges and ensure effective, transparent governance.
Thematic structure of pedagogical agent studies: LDA analysis for the period 2020–2025
(Taylor and Francis Ltd., 2026) Turgut, Yiğit Emrah; Aktı Aslan, Seda; Kopuz, Tuba; Aslan, Alper; Allison, Jordan; Özyurt, Özcan
This study examines 2,360 pedagogical agent (PA) articles published between 2020 and 2025 to identify thematic structures, trends, and research gaps through bibliometric analysis and LDA-based topic modeling. The optimal model produced 10 themes (c_v = 0.4767). The dominant themes—Learner Interaction with Virtual Assistants in Education, Student-Centred Learning and Individual Guidance, and NLP Foundations for Pedagogical Agents—account for 51.3% of publications. Trend analyses revealed consistent growth in both Artificial Intelligence and Pedagogical Design in Education and NLP Foundations for Pedagogical Agents, while Learner Interaction with Virtual Assistants in Education reached saturation. Interaction network results showed these themes at the conceptual core of the field, whereas AI-Driven Medical Chatbots, Knowledge-Based Learning Models, and Student Experiences in Intelligent Learning Environments emerged as future research areas. Overall, findings highlight a strong thematic shift toward artificial intelligence, natural language processing, and student-centered learning.
Relieving the burden of informal caregivers of older adults with cancer: The effect of asynchronous video-based training delivered via mobile devices: A pretest-posttest controlled intervention study
(Routledge, 2026) Pekmezci, Hilal; Akbal Demirci, Yağmur; Albayrak, Özlem; Bakır Yalçın, Eda
This study examines the impact of asynchronous video-based mobile training on reducing stress and caregiving burden among informal caregivers of older adults with cancer. The study was conducted between March 2023 and March 2024 with informal caregivers of older adults with cancer receiving chemotherapy at an oncology center. It is a pretest-posttest control group intervention study. Training videos were sent to informal caregivers, follow-up of patients continued via telephone and online counseling was provided. The participants’ caregiving burden and stress levels were measured using the Zarit Burden Interview and Caregiver Strain Index. The stress levels and caregiving burden of informal caregivers in the intervention group who received asynchronous video-based training via mobile devices and online counseling services were found to have significantly decreased (p <.05). There was a significant decrease in the stress levels of the intervention group compared to the control group in women, singles, and informal caregivers who cared for older adults with cancer and had no other patient/child care responsibilities (p <.05). The study results reveal that mobile health technologies positively affect caregivers, and it is essential to expand such training programs.
