Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Deep learning detection of facial nerve enhancement in Bell’s Palsy
(Wolters Kluwer Medknow Publications, 2026) Akkaya, Habip Eser; Polat, Önder; Hürsoy, Nur; Akpınar, Dorukan İnanç
Background and Objectives: The facial nerve, or seventh cranial nerve, with its complex course and association with multiple pathologies, remains a critical area of study. Bell’s palsy, an idiopathic condition leading to unilateral facial weakness, is frequently diagnosed through magnetic resonance imaging (MRI), which can reveal inflammation or pathology within the facial nerve. However, physiological enhancement can complicate diagnosis, particularly in healthy individuals. This study aimed to assess facial nerve enhancement in Bell’s palsy patients using machine learning algorithms. Methods: We retrospectively analyzed 306 MR images from subjects, including 156 Bell’s palsy patients and 150 controls, and trained a DenseNet-based deep learning model to identify pathological enhancement with an 80% accuracy (area under the curve (AUC) 87%). Results: Our model achieved an accuracy of 80% and an AUC of 87% as compared to neuroradiologist’s decision, demonstrating its potential to aid clinicians in diagnosis. Conclusions: Future studies with external validation and larger datasets may further enhance the clinical applicability of AI-based assessment tools for facial nerve pathologies.
The synergistic protective effects of bioactive catechins in longjing tea: alleviate indomethacin-induced gastric toxicity through modulation of inflammatory and apoptotic pathways
(Frontiers Media SA, 2026) Topçu, Atilla; Toprak Semiz, Ayça; Deniz, Esra; Öztürk, Çiğdem; Nalkıran, İhsan; Sevim Nalkıran, Hatice; Mataracı Karakaş, Sibel; Arpa, Medeni
and consumed tea products worldwide. Although interest in Longjing tea (LT) has grown due to its antioxidant and anti-inflammatory properties, studies exploring its potential health effects remain limited. The purpose of this study was to reveal the potential preventive effects of LT on oxidative stress, inflammation, and apoptosis occurring in gastric ulcers induced by indomethacin. Methods – The composition of LT was determined using HPLC (High-Performance Liquid Chromatography). The control group received only tap water via the oral route for 14 days. The indomethacin-only group was administered 100 mg/kg indomethacin in a single oral dose following 24-h fasting. The indomethacin + famotidine group received 40 mg/kg famotidine via the oral route 1 hour before gastric ulcer induction. The members of the indomethacin + LT group received oral LT for 14 consecutive days. A gastric ulcer was induced after 24-h of fasting, and the experimental groups were sacrificed at the end of the sixth hour. Malondialdehyde, glutathione, cyclooxygenase 1 and 2, vascular endothelial cell growth factor A, nuclear factor kappa B, cleaved Poly ADP-ribose polymerase, pan-Akt, and p-Akt levels were examined at the tissue level. Results – Oxidative stress and inflammation, increased by indomethacin, activated the apoptotic cascade. LT showed partial anti-oxidative changes but significantly suppressed PARP-1 expression. The limited bioavailability of catechins may have restricted protective efficacy. Conclusion – The research showed that LT may be a promising agent with partial antioxidant, anti-inflammatory, and anti-apoptotic properties.
Optical and electrical properties of SiC/p-Si heterojunction
(Springer, 2026) Taşyürek, Lütfi Bilal; Orak, İkram; Sarılmaz, Adem; Özel, Faruk
In this study, SiC was used to manufacture Al/SiC/p-Si/Al heterojunction structure by thermal evaporation method. X-ray diffractometry (XRD) and field emission scanning electron microscope (FE-SEM) analyses were evaluated for the characterization of semiconductor SiC layers. For the electrical characterization of the heterojunction, current-voltage (I-V), capacitance-voltage (C-V), and conductance-voltage (G-V) parameters were measured at room temperature (RT) and under various illumination conditions. Ideality factor (n) and barrier height (Фb) values were calculated as 1.32 and 0.85 eV in the dark and 1.22 and 0.77 eV at 100 mW/cm2 illumination at RT, respectively. The results provide information indicating that Al/SiC/p-Si/Al heterojunction structure is promising for photovoltaic devices.
Multilayer perceptron neural network approach for power quality improvement in a grid integrated PV and electric vehicle systems
(Public Library of Science, 2026) Das, Soumya Ranjan; Sabhahit, Jayalakshmi Narayana; Patro, K. Abhimanyu Kumar; Acharya, Devi Prasad; Mohanty, Asit; Cüce, Erdem
Recently, there has been an increase in the grid integration of electric vehicles (EVs) and solar photovoltaic (PV) systems, primarily driven by two goals: lowering energy costs and decreasing emissions. Numerous research studies have concentrated on the separate effects of integrating PVs and EVs into the grid. Nevertheless, it is important to recognize that as the adoption of PVs and EVs continues to grow, the supply grid will face the cumulative effects of PV and EV integration on power quality (PQ) challenges. To provide a comprehensive understanding, this study examines the joint impact of PVs and EVs on PQ aspects in detail. This study has indicated that EVs and PVs alone can adversely impact grid reliability and PQ because of the variable character of PV source and the unpredictability of EV demand. But multiple research efforts have shown that coordination between PVs and EVs can help to alleviate certain problems that arise from their individual integration. This study demonstrates PQ enhancement in a grid system integrated with PV and EV using a multilayer perceptron neural network (MLPNN) approach. In the system with PV integration, the GWO-ANFIS, MPPT technique is employed for optimizing power extraction. Under balanced non-linear loading conditions, simulation results show that the THD is initially 25.97% without compensation, then decreases to 12.57% with a shunt passive filter (SPF), 3.37% with the application of recursive least squares (RLS), and 1.37% with MLPNN. With much lower THD and quicker convergence, the suggested MLPNN-based controller exhibits improved harmonic mitigation. A comparison between the proposed and existing methods are drawn using the MATLAB/ Simulink platform.
Sex-specific differences in basilar artery vasospasm after subarachnoid hemorrhage: evidence from a rabbit model
(Frontiers Media SA, 2026) Daltaban, İskender Samet; Kanat, Ayhan; Gel, Mehmet Selim; Aydın, Mehmet Dumlu; Demirtaş, Rabia
Background – Subarachnoid hemorrhage (SAH) remains a devastating cerebrovascular disorder in which cerebral vasospasm is a key determinant of secondary injury and outcome. Sex differences are well-documented clinically, women exhibit a higher incidence of aneurysmal SAH and often worse outcomes, but whether biological sex influences vasospasm severity in controlled preclinical settings remains unclear. Methods – In a randomized, controlled rabbit model, we investigated sex-specific differences in basilar artery (BA) vasospasm after SAH. Twenty-four New Zealand White rabbits (12 male, 12 female) were allocated to Control, SHAM, or SAH groups. SAH was induced by cisterna magna injection of autologous blood; SHAM animals received saline. On Day 7, BA segments were harvested for quantitative assessment of vasospasm using the Vasospasm Index (VSI: wall area/lumen area) and blinded qualitative histopathological scoring of smooth muscle contraction, endothelial integrity, internal elastic membrane configuration, and adventitial thickness. Nonparametric statistical tests were used, with male vs. female comparison in SAH as the primary endpoint. Results – Control and SHAM animals showed no significant sex differences in VSI (Control: p = 0.47; SHAM: p = 0.06). In contrast, SAH induced severe vasospasm in males (VSI 2.34 ± 0.63) compared with moderate vasospasm in females (1.27 ± 0.49, p < 0.001). Histopathology corroborated these findings, with severe endothelial disruption and smooth muscle hypercontraction in males versus moderate alterations in females. Conclusion – Male rabbits exhibited significantly more severe vasospasm than females after SAH, despite human epidemiology suggesting greater vulnerability in women. These results demonstrate sex as a fundamental biological variable in SAH pathophysiology and underscore the need for mechanistic studies exploring hormonal, autonomic, and inflammatory mediators. Incorporating sex into experimental design may ultimately inform sex-specific therapeutic strategies for SAH.
