Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Prognostic significance of the systemic inflammation response index (SIRI) in patients with hodgkin lymphoma
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) İlkkılıç, Kadir; Şen, Bayram
Background and Objectives: Interest in biomarkers reflecting the inflammatory nature of Hodgkin lymphoma (HL) is increasing. This study aimed to evaluate the prognostic significance of the Systemic Inflammation Response Index (SIRI) in patients with HL. Materials and Methods: In this study, 105 patients diagnosed with classical HL at the Hematology Clinic of Recep Tayyip Erdoğan University Faculty of Medicine between January 2015 and April 2025 were retrospectively evaluated. Patients were divided into 2 groups according to the SIRI cut-off value. Results: A high SIRI (≥3.78) was significantly associated with advanced disease stage, poor performance status, higher IPS-7 and IPS-3 scores, non-response or partial response to treatment, relapse, and increased mortality. A positive correlation was found between SIRI and IPS 7 scores (p < 0.001, rho = 0.355). In the univariate analysis for progression-free survival (PFS), hemoglobin, IPS 7 score, and SIRI were identified as prognostic factors; in the multivariate analysis, high SIRI was identified as an independent prognostic factor (p = 0.033). In the univariate analysis for overall survival (OS), age, hemoglobin, albumin, lymphocyte count, IPS 7 score, and SIRI were identified as prognostic factors; and, in the multivariate analysis, age over 45 and high SIRI were identified as independent prognostic factors (p = 0.016, p = 0.012). In the survival analysis, high SIRI levels were associated with shorter PFS and OS (p = 0.001, p < 0.001). Additionally, PFS and OS durations were shorter in patients with high IPS 7 scores (p < 0.001, p < 0.001). Conclusions: A high SIRI prior to treatment was identified as an independent prognostic factor in HL patients and was associated with shorter PFS and OS. This index may help identify high-risk patients and assist clinicians in their decision-making processes by enabling individualized risk assessment.
Meta-analysis of effectiveness of pedagogical innovations involving technology in organic chemistry education in developing students’ academic performance
(American Chemical Society, 2026) Sivrikaya, Serpil Özkurt; Çalık, Muhammet; Kurt, Sevil
Because organic chemistry asks students to use visual and spatial thinking skills (e.g., three-dimensional structures of molecules) and comprehend various chemical reactions and mechanisms, it naturally needs pedagogical innovations involving technology to result in better academic performance. However, none of the previous studies has investigated the extent to which these pedagogical innovations are effective in improving students’ academic performance of organic chemistry education. This study aims to meta-analytically assess the effectiveness of the pedagogical innovations involving technology in organic chemistry education in developing students’ academic performance. The current meta-analysis handled 26 studies as the corpus of the data retrieved from the database and manual search. The authors initially coded the studies via a template form and inserted all statistical data from a Microsoft Excel sheet into Comprehensive Meta-Analysis (CMA V2) statistics software to calculate Hedges’ g for the corpus data. The findings pointed to the large effect for the overall effect size (g = 0.973). Also, it was found that only subgroups for the use of technological tools within the moderator variable “type of pedagogical innovations involving technology” played a significant role at predicting the students’ academic performance as a result of the treatments. In light of the findings, it can be inferred that the pedagogical innovations involving technology in organic chemistry education are more effective and fruitful in developing the students’ academic performance than nontechnology-based control groups. Further, the current meta-analysis study concludes that high school (for educational level), flipped classroom (for the pedagogical models including technology), digital media (for the use of technological tools), and short-term treatment (for implementation duration) act as the most effective variables to learn organic chemistry via the pedagogical innovations. Future research should focus on other individual and moderator variables to offer more adaptive alternatives for the use of chemistry teachers and lecturers.
Helically wound superconducting cable production system
(National Academy of Sciences of Ukraine, 2026) Tokçalar, Soner; İnce, Berkan Emre; Karan, Yasin
This study presents an advanced production system for helically wound superconducting cables. The developed system addresses critical challenges in high-current applications (such as power transmission, fusion reactors, and space technologies) by combining modular design with precision engineering solutions. It is directly applicable to the production of superconducting magnets required for particle accelerators and high-energy detector systems. Key innovations of the system include an adjustable tension control mechanism (with a range of 10–20 Nm), multi-axis synchronization (seven-axis motion control), and configurable winding parameters (helix angle between 10∘ and 75∘, diameter range of 6–25 mm). The production platform integrates up to 16 independent tensioning units and provides precision tension management via an adaptive control mechanism. The output of the device confirms the system’s ability to produce industrial-quality superconducting cables while minimizing mechanical deformation. These technological advancements provide a strong foundation for integration into large-scale infrastructure projects in high-energy physics.
Approximate solutions of the lane-emden equations by ls-svm method
(Association of Mathematicians (MATDER), 2026) Şengül, Süleyman; Tali, Hasan Halit
In this study, approximate solutions of the Lane-Emden differential equation, which plays an important role in the literature, were obtained using the Least Squares Support Vector Machines (LS-SVM) method for both linear and nonlinear cases. The Collocation method was employed to define the constraints in the solution process. The system of equations obtained in the linear case was solved directly to determine the unknown parameters, while the Newton-Raphson method was used to solve the nonlinear equation system. The approximate solutions obtained in the applications considered in this study were compared with the exact solution for the linear case; with the analytical solution for the nonlinear case; and with the Adomian Decomposition Method (ADM) in the final application where no analytical solution exists. The results show that the numerical solutions obtained using the LS-SVM method are highly accurate and consistent with the reference results.
Colchicine-treated familial mediterranean fever patients are associated with a lower prevalence of mitral annular calcification
(Wiley, 2026) Cüre, Osman; Durak, Hüseyin; Çetin, Mustafa; Kızılkaya, Bayram; Topaloğlu, Mehmet Serhat
Objective: Inflammation contributes to mitral annular calcification (MAC). This study aimed to evaluate the relationship between MAC and colchicine-treated Familial Mediterranean Fever (FMF). Methods: This cross-sectional study included consecutively enrolled Familial Mediterranean Fever (FMF) patients (n = 98) receiving colchicine (≥ 1 mg/day for at least one year) and controls without FMF (n = 93). FMF was diagnosed according to the Tel-Hashomer criteria. MAC was defined by transthoracic echocardiography as an echogenic structure ≥ 5 mm in thickness located at the posterior mitral annulus. Demographic, clinical, and laboratory data were recorded. Factors associated with MAC were evaluated using univariate and multivariate logistic regression analyses. Results: Among 191 participants, 13 (6.8%) had MAC. Participants with MAC were older, had higher body mass index (BMI), and showed a higher prevalence of diabetes and hypertension compared with those without MAC (all p < 0.05). Multivariate logistic regression analysis demonstrated that age (OR = 1.06, 95% CI: 1.006–1.118), BMI (OR = 1.22, 95% CI: 1.074–1.391), and the presence of FMF (OR = 0.097, 95% CI: 0.012–0.778) were independently associated with MAC. FMF showed an inverse association with the presence of MAC. Receiver operating characteristic analysis demonstrated significant predictive value for age and BMI, while FMF showed an inverse discriminatory pattern (AUC = 0.266, p < 0.001). Conclusion: Colchicine-treated patients with Familial Mediterranean Fever may be associated with a lower prevalence of mitral annular calcification, suggesting a potential long-term cardiovascular protective effect through suppression of chronic inflammation.
