Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Phytochemical analysis and antimicrobial, antioxidant, and cytotoxic activities of Scorzonera aucheriana DC (Asteraceae)
(Elsevier, 2026) Yaylı, Nurettin; Erik, İshak; Korkmaz, Büşra; Bozdal, Gözde; Yalçın, Can Özgür; Coşkunçelebi, Kamil; Makbul, Serdar; Karaoğlu, Şengül Alpay
The present study is mainly focused on the isolation and structure elucidation of four new (1–4), two known astragalin (5), and kaempferol-3,7-di-O- β -D-glucopyranoside (6) from the aerial parts of Scorzonera aucheriana DC. The structures of the isolated compounds were elucidated based on 1D and 2D NMR ( 1 H, 13 C/APT, COSY, HMBC, and HSQC), UV, FT-IR, and HRESI-MS data. The total phenol and flavonoid contents and the antioxidant activity of S. aucheriana crude methanol extract and its fractions (n -hexane, chloroform, ethyl acetate, and water) were investigated. The highest antioxidant activities against DPPH and FRAP were observed in the ethyl acetate fraction of S. aucheriana . The antimicrobial activity of the methanol extract, its solvent fractions, and isolated compounds (1–6) was evaluated against 10 microorganisms. The chloroform and ethyl acetate fractions exhibited antimicrobial activity against all tested microorganisms. Compounds 1–3 , 5 , and 6 exhibited anti-tuberculosis activity with MICs ranging from 30.9 μg/mL to 250 μg/mL. Compounds 2 , 4 , and 5 have also demonstrated moderate antifungal activity, with MICs ranging from 110 μg/mL to 765 μg/mL against C. albicans , a pathogenic yeast. Compounds 1–3 showed almost no cytotoxic activity in L-929 cells.
The effectiveness of a WhatsApp-based educational intervention aimed at improving mothers' fever management: A randomized controlled trial
(W.B. Saunders, 2026) Altay, Gamzegül; Karaaslan, Mehtap Metin; Çelik, İsa
Aim This study aimed to determine the effect of WhatsApp-based education on mothers' knowledge, attitude and practices regarding fever management at home. Method The study was conducted using a randomized controlled experimental design. It included 64 mothers (32 in the intervention group and 32 in the control group) who met the inclusion criteria. The intervention group received online fever management education via WhatsApp messages. Data were collected using the “Mother and Child Information Form”, “Parent Fever Management Scale”, “Fever Management Knowledge, Attitude and Practice Questionnaire” and “E-Health Literacy Scale.” Two-way mixed-design ANOVA was used to examine group, time, and group × time interactions. Results The intervention group demonstrated significantly higher scores compared to the control group, with the intervention having a large effect on fever management ( p < 0.001, η2 = 0.320), fever knowledge, attitude and practice level (p < 0.001, η2 = 0.585), and e-health literacy level (p < 0.001, η2 = 0.215). Conclusion Online fever management education delivered via WhatsApp messages is effective in reducing mothers' fever-related care burdens, increasing fever knowledge, attitude and practice levels, and improving e-health literacy levels. Practice implications Educational content shared via WhatsApp, a widely used application, is easily accessible. These resources can be used by pediatric nurses in clinics as short and effective educational materials for mothers. The clinical trial registration number is NCT07061327 .
Oligosaccharides from Scorzonera yildirimlii and S. zorkunensis, and their potential antimicrobial, enzyme inhibition, cytotoxic effect, and in silico study
(Elsevier, 2026) Yaylı, Nurettin; Korkmaz, Büşra; Bozdal, Gözde; Şahin, Büşra; Arıcı, Şeyma; Makbul, Serdar; Bozdeveci, Arif
In this study, the phytochemical investigation of Scorzonera yildirimlii and S. zorkunensis led to the isolation and identification of eight new oligosaccharide constituents (1–8). Their structures were elucidated through comprehensive spectroscopic analysis (NMR, FT-IR, and mass spectrometry) and comparison with literature data. The structure of isolated compounds were O-α-D-Glcp-(1 → 2)-O-β-D-Fruf-(3 → 1)-O-myo-inositol (1), O-α-D-Glcp-(1 → 2)-O-β-D-Fruf-(3 → 1)-O-epi-inositol (2), O-β-D-Fruf-(2 → 6)-O-α-D-Glcp-(1 → 1)-O-β-D-Glcp (3), O-β-D-Fruf-(2 → 6)-O-α-D-Glcp-(1 → 1)-O-β-D-Galp (4), O-β-D-Fruf-(2 → 6)-O-β-D-Fruf-(2 → 6)-O-α-D-Glcp-(1 → 1)-O-β-D-Glcp (5), O-β-D-Fruf-(2 → 6)-[O-β-D-Glcp-(1 → 4)]-O-α-D-Glcp-(1 → 1)-O-β-D-Glcp (6), O-β-D-Fruf-(2 → 6)-[O-β-D-Glcp-(1 → 4)]-3-OCH3-O-α-D-Glcp-(1 → 1)-O-β-D-Glcp (7), and O-β-D-Fruf-(2 → 6)-[O-β-D-Glcp-(1 → 4)]-O-α-D-Glcp-(1 → 4)-O-α-D-Glcp-(1 → 2)-O-β-D-Fruf (8). The antimicrobial activities of all the isolated compounds (1–8) were investigated against six microorganisms. Compounds 2 and 3 were effective against Mycobacterium smegmatis at minimum inhibitory concentrations (MICs) of 3.13 μg/mL and 3.44 μg/mL, respectively, compared with streptomycin (MIC = 4.0 μg/mL). The enzyme-inhibitory properties of the isolated compounds (1–8) were evaluated against tyrosinase and α-glucosidase. Among the tested compounds, 4 (39.78 ± 10.29 %) exhibited inhibitory activity against tyrosinase, while compound 2 (68.04 ± 4.68 %) exhibited inhibitory activity against α-glucosidase. In silico studies of 1–8 showed the best predicted binding affinities for the Trehalose-LpqY complex in the range of −11.088 kcal/mol to −14.297 kcal/mol, compared to streptomycin (−6.638 kcal/mol). Compounds 1–8 exhibited almost no cytotoxic activity against L-929 cells, further supporting their potential for therapeutic use.
Azabenzimidazole-piperazine compounds as anticancer agents: Synthesis, biological evaluation, and molecular docking studies
(Elsevier, 2026) Akyüz, Gülay; Çalışkan, Nedime; Emirik, Mustafa; İlhan, Süleyman; Atmaca, Harika; Pulat, Çisil Çamli; Menteşe, Emre
The cytotoxic activities of the newly synthesized azabenzimidazole–piperazine hybrid compounds were evaluated against three human cancer cell lines-HCT116 (colon), PC-3 (prostate), and MCF-7 (breast)-as well as the non-cancerous human embryonic kidney cell line HEK-293. Among all tested candidates, compounds 6d, 6k, and 6l demonstrated the most pronounced anticancer activities, exhibiting IC₅₀ values below 25 μM across all three cancer cell lines. Notably, compound 6l inhibited HCT116, PC-3, and MCF-7 cells with IC₅₀ values of 18.4 ± 0.7 μM, 15.2 ± 0.4 μM, and 14.4 ± 0.2 μM, respectively. Compound 6d showed even greater potency against MCF-7 cells (10.7 ± 0.6 μM) and exhibited comparable activity against HCT116 (14.0 ± 0.4 μM) and PC-3 (17.7 ± 1.5 μM) cells. Compound 6k also displayed significant cytotoxicity, with IC₅₀ values of 24.8 ± 1.6 μM for HCT116, 18.7 ± 0.8 μM for PC-3, and 20.2 ± 0.4 μM for MCF-7 cells. The integration of in silico molecular docking results with in vitro cytotoxicity data strongly suggests that the synthesized compounds-particularly 6d, 6k, and 6l-exert their anticancer effects through a multifaceted mechanism of action.
Microwave assisted synthesis of furan/triazole substituted cobalt(ii) phthalocyanine and investigation of electrochromic properties
(Elsevier, 2026) Akyüz, Duygu; Akçay, Hakkı Türker; Bektaş, Yusuf Serdar; Menteşe, Emre
In this study, tetra 4-(4-fluorophenyl)-5-(furan-2-yl)-4H-1,2,4-triazole-3-thio substituted Co(II) phthalocyanine was synthesized from novel, 4-((4-(4-fluorophenyl)-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl)thio)phthalonitrile, compound by microwave irradiation. The novel compounds were characterized by FT-IR, 1H NMR, 13C NMR, mass spectrometric and elemental analysis methods. The electrochemical and in-situ spectroelectrochemical properties of CoPc are determined. During the reduction process, one quasi reversible metal-based and one reversible phthalocyanine-based redox couple were observed. 4-(4-fluorophenyl)-5-(furan-2-yl)-4H-1,2,4-triazole-3-thio- substituent included CoPc electropolymerized on indium tin oxide (ITO) glass electrode. Electrochromic performance of Poly(CoPc) film was recorded with in-situ spectroelectrochemical measurements. The effect on optical contrast thickness of film, solvent and supporting electrolyte was investigated. The color of Poly(CoPc) film changed from green to brown color at 1.40 V and optical contrast was recorded as 34 % at 690 nm in DCM/TBAPF6 electrolyte. In addition, coloring/bleaching time was recorded as about 10 s.
