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Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers
Halıcı Zekai; Polat, Beyzagül; Çadırcı, Elif; Topçu, Atilla; Karakuş, Emre; Köse, Duygu; Albayrak, Abdülmecit; Bayır, Yasin (Elsevier Ireland Ltd, 2016)Purpose: Previously blocking the renin angiotensin system (RAAS) has been effective in the prevention of gastric damage. Therefore, the aim of this study was to investigate the effects of aliskiren, and thus, direct renin ... -
A novel approach to contrast-induced nephrotoxicity: the melatonergic agent agomelatine
Karaman, Adem; Diyarbakır, Büşra; Durur-Subaşı, Irmak; Köse, Duygu; Özbek-Bilgin, Aslı; Topçu, Atilla; Gündoğdu, Cemal; Durur-Karakaya, Afak; Bayraktutan, Zafer; Alper, Fatih (British Inst Radiology, 2016)Objective: To study the potential nephroprotective role of agomelatine in rat renal tissue in cases of contrast-induced nephrotoxicity (CIN). the drug's action on the antioxidant system and proinflammatory cytokines, ...