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Kaempferol reduces pyroptosis in acute lung injury by decreasing ADAM10 activity through the NLRP3/GSDMD pathway
Yiğit, Ertuğrul; Hüner Yiğit, Merve; Atak, Mehtap; Topal, Zehra Suzan; Karabulut, Soner; Yıldız, Gökhan; Değer, Orhan (Elsevier, 2024)Sepsis-associated acute lung injury (SA-ALI) is a significant problem in intensive care units worldwide, and no specific treatment is currently available. Therefore, it is crucial to identify new potential therapeutic ... -
Synthetic and non-synthetic inhibition of ADAM10 and ADAM17 reduces inflammation and oxidative stress in LPS-induced acute kidney injury in male and female mice
Atak, Mehtap; Yiğit, Ertuğrul; Hüner Yiğit, Merve; Topal Suzan, Zehra; Yılmaz Kutlu, Eda; Karabulut, Soner (Elsevier, 2024)Acute kidney injury (AKI) is a severe medical condition that can lead to illness and death. A disintegrin and metalloprotease (ADAM) protein family is a potential treatment target for AKI due to its involvement in inflammation, ...
