Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Facing death: the last drawings of a woman with breast cancer at the end of life
(Nature Research, 2026) Rakıcı, Sema Yılmaz; Çetin, Bülent; Aydın, Esra; Gürsel, Bilge
Drawing offers a powerful means of expressing lived experience when words fail. This commentary analyzes the final drawings of a woman with breast cancer, examining how her artwork reflects an evolving confrontation with mortality across diagnosis, recurrence, and metastatic disease. Grounded in existential psychology, the article highlights grief, hope, faith, and death awareness, and argues for integrating psychological and spiritual perspectives into palliative and end-of-life care for patients and families.
Parental perceptions of antibiotic use in pediatric dentistry: a cross-sectional study using the PAPA scale
(BioMed Central Ltd, 2026) Çağlan, Şeyma Lök; Aydınoğlu, Sema; Günaçar, Dilara Nil
Background: Parental awareness regarding antibiotics might influence pediatric oral health. This study aimed to assess parents’ knowledge of antibiotic use and its relationship with their children’s oral health. Methods: This study included 805 children (ages 3–14 years) and their parents. A face-to-face questionnaire with 45 items was used to assess parental knowledge and attitudes using the PAPA (Parental Perceptions on Antibiotics) scale. Children’s oral health was clinically evaluated using DMFT (decayed, missing, and filled teeth) and PUFA (pulpal involvement, ulceration, fistula, and abscess) indices. Statistical analyses included the Mann–Whitney U test, Kruskal–Wallis test, independent samples T-test, Spearman’s rank correlation, and negative binomial regression. Results: There were significant negative correlations between parents’ PAPA scores and their children’s decayed teeth, DMFT, pulpal involvement, fistula formation, abscess, and PUFA scores (p < 0.05). Children with previous antibiotic use for dental pain had significantly higher missing teeth, DMFT, pulpal involvement, fistula formation, abscess, and PUFA scores (p < 0.05). Parents who sought professional care after symptoms in their children had subsided following antibiotic use had higher PAPA scores and better oral health outcomes in their children (p < 0.05). Conclusions: Increased parental knowledge and positive attitudes toward antibiotic use were associated with improved oral health outcomes in their children. Trial registration: The trial protocol was registered under ClinicalTrials.gov (ID: NCT07112079) on August 7, 2025. Retrospectively registered.
A nanophytomedicine approach including tea tree essential oil for possible dental applications: in vitro and in silico evaluations
(Bentham Science Publishers, 2025) Budama Kılınç, Yasemin; Çakmakcı, Nisanur; Keçel Gündüz, Serda; Suyabatmaz, Şeyma; Karaoğlu, Şengül Apay; Yılmaz Atalı, Pınar; Kartal, Murat
Introduction: Tea tree essential oil (TTO) incorporated polylactic-co-glycolic acid (PLGA) nanoparticulate powder form was aimed to desined that can be applied with water and is effective against oral pathogens to prevent caries, and that is able to provide a long-lasting oral antiseptic effect. Methods: TTO-PLGA nanoparticles (TTO-NPs) was synthesized by single emulsion technique; average particle size, PdI value and zeta potential was measured by Zetasizer; TTO-PLGA interactions were investigated by FTIR, and morphological analysis was performed by TEM analysis. Phytoactive release and performans tests were carried out with in vitro dissolution and DNA binding-cleavage tests while antimicrobial performance was investigated by Ames-Salmonella assay, susceptibility test, in silico Molecular Docking and Molecular Dynamics studies. Results: TTO-NPs had an average particle size of 221.6 nm, a PdI of 0.103, and a zeta potential of -5.22 mV, 59.25% encapsulation efficiency and 25.65%. loading capacity. At the end of 5 h and 72 h the TTO release was 33.34±2.17% and 97.61±3.91% respectively. TTO-NPs were not mutagenic and were effective on investigated four cariogenic bacteria. The binding interactions of terpinen-4-ol, the main component of TTO, with Streptococcus mutans and Lactobacillus casei were revealed with enzyme-active-site-key residues. Discussion: In vitro and in silico studies confirmed that TTO-NPs were non-mutagenic and exhibited strong antimicrobial activity against dental caries-causing bacteria like Streptococcus mutans and Lactobacillus casei. Conclusion: In conclusion, TTO-NPs, which can be used as a mouthwash or powder, represent a promising solution for reducing oral pathogens, meriting further in vivo and clinical evaluations.
Growth hormone, insulin-like growth hormone-i axis, and bone fragility
(Springer Nature, 2026) Uygur, Meliha Melin; Acanfora, Matteo; Frara, Stefano; Giustina, Andrea
Growth hormone (GH) and insulin-like growth factor-I regulate skeletal physiology, and both excessive and deficient levels affect bone remodeling and alter bone microstructure. Bone quality is affected more than bone quantity, and vertebral fractures (VFs) are an early phenomenon of impaired bone health. Since fractures cannot be accurately predicted by areal bone mineral density, emerging data demonstrate that a morphometric approach is essential for evaluating bone health given their predictive role in both clinical settings. Several novel tools assessing bone quality and bone remodeling have been proposed as alternative or additional methods for the prediction of fractures. Prompt disease control of acromegaly and GH replacement therapy for GH deficiency (GHD) are fundamental for the restoration and maintenance of skeletal health. Replacement of other pituitary deficiencies, especially sex hormones, should be provided for advanced bone outcomes in patients with GHD with cautious replacement of glucocorticoids and levothyroxine to avoid overtreatment. Vitamin D has proved to be very effective in the prevention of VFs in the case of acromegaly and in improvement of bone microarchitecture when combined with GH replacement therapy in patients with GHD. The effectiveness of bone active drugs in the prevention of VFs in both clinical settings needs to be clarified.
Structure–activity relationships of morpholine-modified silicon(iv) phthalocyanines as potential antidiabetic agents
(Royal Society of Chemistry, 2026) Keleş, Turgut; Bıyıklıoğlu, Zekeriya; Seyhan, G.; Barut, Burak
Type 2 diabetes mellitus (DM) is a chronic metabolic disorder with a rapidly increasing global prevalence, highlighting the need for safer and more effective therapeutic strategies. In this study, a series of axially disubstituted silicon(iv) phthalocyanines bearing morpholine functional groups and their water-soluble derivatives were synthesized, structurally characterized, and evaluated for their antidiabetic potential. The synthesized compounds were characterized by FT-IR, 1H and 13C NMR, UV–Vis spectroscopy, and mass spectrometry. The in vitro antidiabetic activity of the compounds was evaluated through α-glycosidase and α-amylase inhibition assays. The non-ionic silicon(iv) phthalocyanine derivatives MT-C3-H-Si and MT-C3-D-Si exhibited strong α-glucosidase inhibitory activity with IC50 values of 16.02 ± 0.94 μM and 44.14 ± 4.06 μM, respectively, showing higher potency than the standard inhibitor acarbose (IC50 = 60.51 ± 4.66 μM). In contrast, the water-soluble derivatives MT-C3-H-SiQ and MT-C3-D-SiQ displayed lower inhibitory activity (IC50 = 68.80 ± 5.12 μM and >100 μM, respectively), indicating that increased hydrophilicity does not necessarily enhance enzyme inhibition. All compounds exhibited weak α-amylase inhibition (IC50 > 100 μM) compared with acarbose (IC50 = 25.29 ± 3.50 μM). Kinetic studies revealed that MT-C3-H-Si and MT-C3-D-Si inhibit α-glycosidase via a non-competitive mechanism, with Ki values of 9.45 ± 1.45 μM and 29.06 ± 5.16 μM, respectively. This is characterized by decreased Vmax values without significant changes in Km, suggesting interaction with allosteric regions of the enzyme. Overall, these findings highlight axially disubstituted silicon(iv) phthalocyanines as promising molecular scaffolds and contribute valuable insight into the limited literature on their antidiabetic enzyme inhibition properties.
