Yazar "Malkoç, İsmail" için listeleme
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A comparative investigation of the nephrotoxic effects of various antihypertensive drugs in rats: biochemical and histopathological analysis
Malkoç, İsmail; Altunkaynak, Konca; Turan, Mehmet İbrahim; Gürsan, Nesrin; Hacımüftüoğlu, Ahmet; Akçay, Fatih; Üçüncü, Yılmaz; Süleyman, Halis (Carbone Editore, 2014)Aims: Hypertension is known to cause potentially fatal kidney damage. However, it is unclear whether long-term use of antihypertensive drugs establishes any toxic effect on the kidney. This study investigate whether ... -
Comparative review of biochemistry and cell anatomy of the hepatic tissue in rats administered some anti hypertensive drug for a long time
Malkoç, İsmail; Çetin, Nihal; Altuner, Durdu; Hacımüftüoğlu, Ahmet; Gürsan, Nesrin; Bakan, Ebubekir; Akçay, Fatih; Süleyman, Halis (2012)The adverse biochemical and structural effects of antihypertensive drugs over a long period (clonidine, methyldopa, rilmenidine, amlodipine, ramipril) on hepatic tissue has been examined in this study. The results are ... -
Effect of hippophae rhamnoides extract on oxidative oropharyngeal mucosal damage induced in rats using methotrexate
Erhan, Ertuğrul; Terzi, Suat; Çeliker, Metin; Yaralı, Oğuzhan; Çankaya, Murat; Çimen, Ferda Keskin; Malkoç, İsmail; Süleyman, Bahadır (Korean Soc Otorhinolaryngol, 2017)Objectives. the objective of this study is to investigate and evaluate the effect of Hippophae rhamnoides extract (HRE) on oropharyngeal mucositis induced in rats with methotrexate (MTX) through biochemical, gene expression, ... -
Effect of thiamine pyrophosphate on oxidative damage to the oropharyngeal, nasal and cochlear tissues induced by doxorubicin in guinea pigs
Erhan, Ertuğrul; Turan, Fatih; Terzi, Suat; Çeliker, Metin; Mammadov, Renad; Malkoç, İsmail; Kukula, Osman; Çankaya, Murat (Colegio Farmaceuticos Provincia de Buenos Aires, 2017)Doxorubicin (DOX) inhibits the enzyme tyaminpyrophosphokinase (TPK). Hence the synthesis of thiamine pyrophosphate (TPP) which is the active metabolite of thiamine stops. This leads to oxidative damage. in the literature, ... -
The impact of resveratrol on oxidative stress induced by methotrexate in rat ileum tissue: evaluation of biochemical and histopathological features and analysis of gene expression
Öçiçek, Adalet; Çetin, Nihal; Çimen, Ferda Keskin; Tuümkaya, Levent; Malkoç, İsmail; Gulaboğlu, Mine; Yaralı, Oğuzhan; Süleyman, Bahadır (Karger, 2016)Objective: the aim of this study was to assess the impact of resveratrol (RST) on oxidative stress induced by methotrexate in rat ileum tissue. Materials and Methods: Twenty-four rats were divided into 4 groups with 6 in ...