Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Molecular characterization of Enterococcus spp. from honey bees in Türkiye: antimicrobial resistance and virulence gene profiles
(Taylor and Francis Ltd., 2025) Sevim, Elif; Alpay Karaoğlu, Şengül; Bozdeveci, Arif; Suyabatmaz, Şeyma; Vatandaşlar, Sinem; Sevim, Ali; Serdar, Gülnur
The genus Enterococcus consists of Gram-positive, non-spore-forming, catalase-negative, facultative anaerobic bacteria that can occur both as single or diplococci and in chains. Commensal microorganisms of the gastrointestinal tract of humans and animals, including this genus, acquire high antimicrobial resistance and virulence genes and can turn into opportunistic pathogens. In this study, 42 Enterococcus spp. were isolated and identified by conventional and molecular (ddl gene sequence) methods from honey bee specimens in Türkiye. Of the isolates, 37 (88%) were identified as E. faecalis and five (12%) as E. faecium. Antimicrobial resistance profiles against nine antibiotics were determined by the disk diffusion method. Antibiotic resistance genes and eight different virulence genes were characterized by molecular methods. Of the 42 isolates, 24 (57%) were resistant to erythromycin, six (14%) were resistant to streptomycin, three (7%) were resistant to tetracycline, and two (2%) were resistant to ciprofloxacin. ermB resistance gene was detected in 16 (80%) of 24 erythromycin-resistant E. faecalis isolates and in 100% of four E. faecium isolates. The tetM gene was identified in three tetracycline-resistant strains. “ant(6)-Ia”, “aac(6’)-le-aph(2’’)-Ia” and “acc(6)-Ii” gene co-existence were determined in 6 strains, one of which was E. faecium. Only two of 8 virulence genes (esp and hyl genes) were not detected in any strain, while the gene encoding the sex pheromones determinant and gelatinase protein was detected in 95% of the strains. Antibiotic resistance, resistance, and virulence genes in Enterococcus species isolated from honey bees could pose potential risks to bee health.
Metabolic dysfunction-associated steatohepatitis treatment: spotlight on the latest hepatoprotective drugs
(Taylor and Francis Ltd., 2025) Kaya, Eda; Yılmaz, Yusuf; Alkhouri, Naim
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a major public health concern. Recently, the development of liver-targeted pharmacologic therapies has gained momentum, culminating in the conditional approval of resmetirom which has generated renewed optimism for the management of MASLD. In addition, several other investigational agents have shown promising results in clinical trials. Areas covered: In this review, we summarize the data on recent pharmacologic developments in the treatment of MASLD, with a particular focus on agents targeting the more progressive form–at-risk metabolic dysfunction-associated steatohepatitis (MASH). These therapies act through a variety of direct and indirect pathways within the liver. Expert opinion: The approval of liver-targeted therapies for MASH marks the beginning of a new era in disease management, offering promising outcomes even for advanced stages such as cirrhosis. The rising prevalence of obesity and T2DM suggests that new treatment options that can treat multiple comorbidities–including GLP1 receptor agonists, dual, and multi-agonists–are likely to play a significant role in the management of MASH. The availability of effective pharmacologic treatment options highlights the need for effective screening strategies in high-risk populations and call for the engagement of policymakers to develop coordinated plans at a global level.
First record of the doctor fish in Antalya (Türkiye) outside its natural distribution range: Taxonomic identity and potential ecological risks
(Taylor and Francis Ltd., 2025) Güçlü, Salim Serkan; Kaymak, Nehir; Kalaycı, Gökhan
This study investigates the presence of Garra turcica Karaman, 1971, commonly known as doctor fish, in the Antalya region, which lies far beyond its natural distribution range, which is restricted to the eastern part of the Mediterranean Region of Türkiye. The findings suggest that the introduction of G. turcica to Antalya’s rivers is likely linked to human activities, particularly its use in health tourism for fish spa treatments. Morphological and ecological assessments were conducted, and the species identity was confirmed as G. turcica by genetic analysis. The findings indicate that its presence in the Antalya region could potentially pose ecological risks, including competition with native species and possible disease transmission. In addition, the species’ broad thermal tolerance and adaptability may increase the likelihood of its establishment in the region, suggesting the need for further monitoring and population-based studies to assess its long-term impacts.
On symmetric potential in a boundary value problem dependent on an eigenparameter
(American Institute of Mathematical Sciences, 2025) Başkaya, Elif; Şengül, Süleyman
In this work, we asymptotically calculate the eigenvalue of a boundary value problem that involves an integrable and symmetric potential over a defined interval and includes eigenvalues in the boundary conditions. We apply the Riccati equation to derive the asymptotic solutions. To validate our findings, we compare them with numerical results obtained using the element–free Galerkin method. The comparison confirms the consistency and accuracy of the asymptotic approach.
New technological application in the preparation of Ag-containing graphene oxide structure: cryogenic coating method
(Springer, 2025) Nevruzoğlu, Vagif; Kaya, Mehmet; Manir, Melih; Altuntaş, Derya Bal; Şesşn, Zeliha Kübra
In this study, graphene oxide (GO) structure was doped with metallic silver (Ag) atoms in vacuum environment (10–6 Torr) at 200 K. GO and GO/Ag samples were analyzed using X-ray diffractometry (XRD), scanning electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy and optical and electrochemical impedance spectroscopy (EIS). XRD patterns showed that the samples investigated grew in the hexagonal structure (2θ = 9.4°). However, reflection peaks originating from Ag were observed in the XRD patterns of GO/Ag samples. SEM images showed that there was an increase in grain size and layer number in the GO structure with Ag doping. Bond vibrations originating from carbon, oxygen and hydrogen atoms were observed from the FTIR spectra. In addition, ID/IG ratios of GO and GO/Ag samples were calculated and found to be 0.89 and 0.82, respectively. From optical measurements, it was seen that surface plasmon resonance (SPR) event occurred at 430 nm wavelength in GO/Ag samples. Electrical properties of samples were examined under different wavelength beams (room, 366 nm and 450 nm) during measurement using EIS method (“Room” refers to the normal lighting in the room environment.). The lowest charge transfer resistance was observed in GO/Ag sample illuminated with 450 nm wavelength. Then, solutions containing GO and GO/Ag were prepared and two different diode structures were produced by spraying them onto p-Si crystal surface by chemical sputtering method. Characteristics of diodes in dark and light environments (100 mW/cm2) were examined, and it was seen that diode-containing Ag exhibited better photovoltaic values.
