Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Bioprospecting honeybee-derived Bacillus sp.: Metabolite profiling, antimicrobial, antifungal and antioxidant activities
(Springer, 2025) Karaoğlu, Şengül Alpay; Vatandaşlar, Sinem; Suyabatmaz, Şeyma; Bozdeveci, Arif; Yaylı, Nurettin; Dizman, Yeşim Aktürk; Baltaş, Nimet; Akpınar, Rahşan
Background: The aim of this study is to characterize Bacillus sp. strains isolated from healthy honeybees (Apis mellifera) and the metabolites they produce in growth medium, and to ascertain their antimicrobial and antioxidant activities. Methods and results: With the characterization of Bacillus sp. strains, microscopy, resistance to harsh conditions, biochemical tests, antibiograms, antibacterial and antifungal activities were tested. Bacillus strains exhibited optimum growth at 35 °C, pH 8.0, 5% salt, and 20% glucose-containing medium. Antimicrobial activity of supernatants and extracts against Gram (+) bacteria and some fungi was observed. According to 16S rRNA sequence analysis, the isolates were determined to be similar to Bacillus sp. As a result of experiments with different solvents, ethyl acetate was used in purification and experiments because the extraction efficiency was higher. The chemical and structural properties of the 4 purified substances were determined by NMR analysis. These compounds (C₇H₁₃NO, C₁₂H₂₂O₁₁, C₁₈H₃₄O, C₈H₁₁NO) exhibited no antifungal efficacy; in contrast, C₁₂H₂₂O₁₁ and C₁₈H₃₄O displayed comparable antibacterial effects. C₁₈H₃₄O exhibited a much stronger antimicrobial effect due to its lower minimum inhibitory concentration (MIC) values, whereas C₁₂H₂₂O₁₁ showed relatively low activity. While C₇H₁₃NO was effective only against Escherichia coli, C₈H₁₁NO showed broad-spectrum activity against all bacterial species. It was determined that the liquid medium in which Bacillus sp. strains were grown had antioxidant activity. Conclusions: The isolated Bacillus sp. strains produce metabolites with significant antibacterial and antioxidant activities, suggesting their potential as sources of bioactive compounds, although no antifungal activity was detected.
A comprehensive risk analysis for cargo leakage pollution at tanker ship manifold under cloud modelling and Bayesian belief network approach
(Elsevier, 2025) Elidolu, Gizem; Sezer, Şükrü İlke; Akyüz, Emre; Gardoni, Paolo; Aydın, Muhammet
Oil and chemical tankers play a vital role in global trade, but pose significant environmental risks from potential cargo spills. The manifold area, a critical connection point during loading and unloading operations, is particularly vulnerable to spillage incidents caused by equipment failure, improper hose handling and operator error. This paper assesses the pollution risks associated with cargo spills in the manifold section of tankers by identifying and analysing the key risk factors. A total of 15 risk factors contributing to cargo spillage are identified, including valve malfunction, hose deformation, incorrect gauge installation, inadequate hose support and vessel position shifts. The Cloud Model (CM) and Bayesian Belief Network (BBN) methods are used to quantify and assess these risks. The CM approach is used to deal with uncertainty in expert judgment, while the BBN is used to establish causal relationships between risk factors. Sensitivity analysis reveals that valve failure, hose deformation, incorrect gauge installation, inadequate hose support and vessel position shifts are the most critical contributors to leak incidents. The findings provide valuable insights into risk mitigation strategies and suggest safety measures to minimise pollution risks in tanker operations.
A regional genetic study of primary monosymptomatic nocturnal enuresis using chromosomal microarray analysis
(Urology and Nephrology Research Centre, 2025) Yaralı, Oğuzhan; Naralan, Yüksel Sümeyra
Purpose: This study aimed to investigate the genetic heterogeneity of primary monosymptomatic nocturnal enuresis (PMNE) and assess potential genetic variants contributing to its etiology. Materials and Methods: A total of 92 children aged 5–15 years with a positive family history of PMNE were evaluated. All patients underwent detailed urological and nephrological assessments to exclude organic causes. Genetic testing was performed using high-resolution chromosomal microarray technology to identify potential pathogenic variants. Results: No pathogenic or likely pathogenic copy number variations were identified. A small number of patients exhibited variants of uncertain significance (VUS), none of which were conclusively linked to PMNE after parental segregation analysis. Our findings challenge previous studies that reported significant genetic markers and highlight the complex genetic architecture of PMNE. Conclusion: This study reinforces the genetic heterogeneity of PMNE and suggests it follows a polygenic and multifactorial inheritance pattern. Further research using whole-exome and whole-genome sequencing is needed to explore potential genetic contributors alongside environmental factors. ©
The topographic map of the marginal mandibular nerve: implication for submandibular gland resection surgeries
(Wiley, 2025) İsmailoğlu, A.V.; Al, O.S.; Yazı, S.; İsmailoğlu, Pelin; Aktekini M.; Şehirli, U.S.
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Research on solar fuels based on azobenzene/g-C3N4 photoinduced isomerization energy storage
(Royal Soc Chemistry, 2025) Zhang, Li; Jin, Yonglei; Jin, Jing; Zhang, Yazhu; Guo, Changcheng; Wang, Haofeng; Cüce, Erdem
Solar photothermal chemical fuels collect and store solar energy through molecular structure changes and release the stored energy in the form of heat. Molecular software was used to construct molecular models of azobenzene and azobenzene-graphite-like phase carbon nitride (AZO-g-C3N4), and structure optimization and energy calculations were carried out on the models based on density functional theory. The isomerization recovery time of azobenzene is prolonged by grafting g-C3N4, and its energy is increased by 0.87-1.50 eV compared with that of the pre-grafting model. Four azobenzene monomers with different structures were experimentally designed to be grafted onto g-C3N4 templates to form AZO-g-C3N4 hybrid materials. Compared with that of the original azobenzene, the half-life of the grafted g-C3N4 increased from 4 h, 6 h, 12 h, and 15 h to 57 h, 82 h, 164 h, and 223 h, respectively; the thermal stability of the grafted AZO-g-C3N4 material was improved by 77-171%, and the energy density reached 32.15 Wh kg-1, 39.6 Wh kg-1, 60.3 Wh kg-1, and 75.79 Wh kg-1, respectively, with high thermal storage and release capability. Results show that the use of azobenzene-grafted g-C3N4 templates is an effective method to improve the half-life, thermal stability, and energy storage density of solar fuel recovery systems.
