Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
A dose-dependent study examining dexmedetomidine’s possible effects against oxidative, fibrotic, and apoptotic damage induced by radiation exposure in spleen tissue
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Beyazal Polat, Hatice; Yılmaz, Hamit; Kılınç, Kağan; Gülhan, Belemir; Yılmaz Rakıcı, Sema; Tümkaya, Levent
Objective: This study aimed to investigate the potential splenic tissue damage induced by radiotherapy (RT) and the potential protective effect of different doses of dexmedetomidine on this damage at the histopathological, immunohistochemical, and biochemical levels. Materials and Methods: In our study, Sprague Dawley rats were randomly divided into four groups: Control, Radiotherapy (RT; 8 Gy), RT + Dexmedetomidine 100 µg/kg (RT-D100), and RT + Dexmedetomidine 200 µg/kg (RT-D200). A single dose of 8 Gy radiotherapy was administered to each RT group. Spleen tissues were examined histologically with hematoxylin-eosin and immunohistochemically with anti-Caspase-3, anti-TGF-β1, and anti-TGF-β3 using light microscopy. TBARS and total thiol levels were also analyzed to assess oxidative stress and antioxidant capacity. Results: Histopathological results showed a significant decrease in white pulp diameter, decreased cellular density, and increased congestion in the red pulp in the RT group. Significant fibrosis, sinusoidal dilatation, vacuolization, and amyloid deposition were detected in the white pulp in the RT group. Regarding anti-caspase-3 immunoreactivity, strong positivity increased in the red pulp in the RT group, while a significant increase was observed in the white pulp in both the RT-D100 and RT groups. While the proportion of TGF-β1 immunopositive cells did not change significantly in the RT group, they increased significantly in both dexmedetomidine groups (especially RT-D200). TGF-β3 expression increased significantly only in the RT-D100 group. In biochemical analyses, TBARS levels increased significantly in the RT-D100 group. Total thiol levels decreased in the RT group and increased in the dexmedetomidine-treated groups. Conclusions: While RT caused histopathological damage and increased oxidative stress in spleen tissue, dexmedetomidine reduced this damage in a dose-dependent manner. The different immunohistochemical profiles of TGF-β1 and TGF-β3 suggest that these cytokines may have different functions in the spleen. 100 µg/kg dexmedetomidine stimulates a regenerative response through TGF-β3, while 200 µg/kg dexmedetomidine may provide immune regulation and antioxidative defense through TGF-β1.
Translation and power in Georgia: Postcolonial trajectories from socialist realism to post-soviet market pressures
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Öztürk, Gül Mükerrem
This study examines the transformation of literary translation practices in Georgia from the Soviet era to the post-Soviet and neoliberal periods, using postcolonial translation theory as the main analytical lens. Translation is treated not merely as a linguistic transfer but as a process shaped by ideological control, cultural representation, and global power hierarchies. In the Soviet era, censorship policies rooted in socialist realism imposed direct ideological interventions; children’s literature such as Maya the Bee and Bambi exemplified how religious or individualist themes were replaced with collectivist narratives. In the post-Soviet period, overt censorship has largely disappeared; however, structural factors—including the absence of a coherent national translation policy, economic precarity, and dependence on Western funding—have become decisive in shaping translation choices. The shift from Russian to English as the dominant source language has introduced new symbolic hierarchies, privileging Anglophone literature while marginalizing regional and non-Western voices. Drawing on the Georgian Book Market Research 2013–2015 alongside archival materials, paratextual analysis, and contemporary case studies, including the Georgian translation of André Aciman’s Call Me By Your Name, the study shows how translators negotiate between market expectations, cultural taboos, and ethical responsibility. It argues that translation in Georgia remains a contested site of cultural negotiation and epistemic justice.
Sacred silence and the genealogy of the nation: Religious and metaphysical dimensions in the poetry of Nikoloz Baratashvili
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Öztürk, Gül Mükerrem
This article examines how national identity is constructed through religious representations in the poetry of Nikoloz Baratashvili, one of the leading figures of 19th-century Georgian Romanticism. Through a text-centered analysis of four key poems, it explores how a religious memory woven around motifs of sacred silence, divine absence, and sacrificial imagery is transformed into a poetic narrative within a postcolonial context. Drawing on the theoretical frameworks of Søren Kierkegaard, Paul Ricoeur, Edward Said, and post-Soviet Georgian thinkers, the study interprets Baratashvili’s poetry as an expression of an existential national narrative. It argues that the poet’s poetics articulate both individual and collective trauma and that the nation is reimagined as a metaphysical community. In this regard, the study offers an interdisciplinary contribution focused on how the Georgian national genealogy is constructed poetically, the role of Orthodox cultural symbolism, and the impact of colonial modernity.
Diagnosis and risk factors in retinopathy of prematurity: a five-year single-center descriptive study
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Sümer, Fatma; Kanburoğlu, Mehmet Kenan; Altuntaş, Özgür; Uzun, Fatma Erbatur; Uslubaş, Işıl; Uzun, Feyzahan; Kanar, Aytaç
Objective: We aimed to determine the incidence and screening outcomes of retinopathy of prematurity (ROP) in preterm infants managed at a tertiary neonatal intensive care unit (NICU) and to identify associated risk factors. Material and Methods: Medical records of 454 premature infants who underwent ROP screening between April 2016 and August 2021 were retrospectively analyzed. Infants with birth weight (BW) ≤ 1500 g or ≤32 weeks of gestational age and those with BW > 1500 g or GA > 32 weeks who had an unstable clinical course were included. All of them were born in the same center. Demographic characteristics, potential risk factors for ROP, ocular examination findings, and treatment requirement were recorded. Results: During the five-year study period, ROP was observed in 75 (16.6%) of a total of 454 premature infants with a mean gestational age (GA) of 30.19 ± 2.49 weeks and a mean BW of 2025.15 ± 614.46 g in the NICU. Of these patients, 67 (14.8%) had stage I disease and 8 (1.8%) had stage II disease. Advanced-stage ROP was not detected in any of the cases. The median GA of patients diagnosed with ROP was 29 weeks (22–35) and the median BW was 2100 g (500–3750), which were significantly lower than those without ROP (p < 0.001). When multivariate logistic regression analysis was evaluated with the Wald method, the accuracy rate of the model examining the combined effect of GA, intraventricular hemorrhage (IVH), respiratory distress syndrome (RDS), patent ductus arteriosus (PDA), necrotizing enterocolitis (NEC), and surfactant treatment was 85.9%. In this model, gestational age (OR: 0.712, p < 0.001), IVH (OR: 2.915, p = 0.010), RDS (OR: 2.129, p = 0.004), NEC (OR: 3.679, p < 0.001), PDA (OR: 2.434, p = 0.021), and surfactant treatment (OR: 2.271, p = 0.002) were found to be independent risk factors for ROP development. Conclusions: Small GA and low BW are the main risk factors for the development of ROP. The incidence of ROP was found to be lower than similar studies conducted in our country. While severe ROP cases have been reported in more mature infants in Turkey, our study found no treatment-requiring ROP cases, likely reflecting the higher mean GA and BW characteristics of our cohort.
A bibliometric evaluation of the use of biomimicry as a nature-compatible design approach in landscape architecture within the context of sustainability and ecology
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Ali, Rayan; Dinçer, Deryanur
Background: The growing environmental crisis, driven by population increases and rapid urban development, has amplified the need for sustainable and ecological design approaches. Biomimicry, drawing inspiration from nature’s forms, processes, and systems, offers promising solutions in this context. Particularly in landscape architecture, biomimicry supports the integration of esthetics with ecological responsibility. Methods: This study presents a bibliometric analysis using the Scopus database to quantitatively assess the relationship between biomimicry and sustainable/ecological design within landscape architecture. A stepwise search strategy was applied, and the Biblioshiny tool within the version 4.2.1 of Bibliometrix package in RStudio 2024.04.1+748 software was used for data analysis and visualization. Results: A total of 1634 documents were identified under the keyword “biomimicry,” among which 210 addressed sustainability and/or ecological design. However, only three studies explicitly connected biomimicry, sustainable/ecological principles, and landscape architecture. Keyword trends, publication years, and country-level contributions were also examined. Conclusions: The findings highlight a substantial gap in the literature on the integration of biomimicry within sustainable landscape architecture. This underscores the need for further interdisciplinary research and practice that incorporates biomimetic principles to promote ecological innovation in landscape design.
