Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Effect of propolis extracts on OxLDL and LOX-1 Levels in ApoE knockout mice fed a high fat diet
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Korkmaz, Katip; Değer, Orhan; Yiğit, Ertuğrul; Uydu, Hüseyin Avni; Mercantepe, Tolga; Demir, Selim
Atherosclerosis, which has important effects on the development of cardiovascular diseases, is a widespread health problem with the highest mortality rate globally. In this study, we aimed to assess the impact of water and ethanolic extracts of propolis on oxidized low-density lipoprotein (OxLDL) and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in the progression of the atherosclerotic process, which is characterized by oxidative stress, inflammation, and dyslipidemia. In our study, apolipoprotein E knockout (ApoE−/−) and C57BL/6J mice were used as study groups. Water (WEP) and ethanolic extracts (EEP) of propolis were administered intraperitoneally to ApoE−/− and C57BL/6J mice modeled with a high-fat diet. Under anesthesia, the animals were euthanized by decapitation, and serum, along with aortic tissues, was collected. Serum total cholesterol (TC), triglyceride (TG), OxLDL and LOX-1 levels, OxLDL levels in aortic tissue homogenate, and subendothelial lipid accumulation levels by histological staining were determined in mice and statistical analyses were performed. WEP and EEP supplementation significantly decreased serum TC, TG, OxLDL, LOX-1, and tissue OxLDL levels and reduced plaque burden in the aortic root, with statistically significant differences observed. Those results suggest that propolis extracts have a potential treatment option for atherosclerosis, as a food supplement or a complementary medical/functional food. However, further research is needed to elucidate their molecular mechanisms, evaluate clinical efficacy and safety, and explore possible synergistic effects with existing atherosclerosis treatments.
Shoaling and sedimentation dynamics in fishery shelters: a case study of sandıktaş fishery shelter
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Süme, Veli; Yılmaz, Enver; Marangoz, Hasan Oğulcan; Daneshfaraz, Rasoul; Ebadzadeh, Parisa; Abraham, John Patrick
Sediment transportation on coasts can be significantly affected by rivers, wave–wind effects, and human activities. As a result, undesirable effects such as shoaling or erosion may occur in fishery shelters. This study examines the “Sandıktaş a Fishery Shelter”, a coastal structure in the Eastern Black Sea region of Turkey, and its susceptibility to shoaling. Bathymetric measurements were performed within the nearshore and onshore, and sediment samples were taken periodically from selected points and analyzed in the laboratory. The characteristic grain diameters of the sedimentation were obtained. It was revealed that the average grain diameter was d50 = 0.30–0.91, caused by an increase of 11,611 m3 in shoaling, which caused the decrease of 8 cm water depth that occurred between 2019 and 2022. The entrance of the fishery shelter has become progressively shallower, making it difficult for boats to navigate. Existing breakwater configurations played a role in trapping sediments, requiring optimized breakwater designs/modifications for improved sediment control. The Mann–Kendall test showed an increasing trend in sediment accumulation, particularly in coarser fractions. The findings highlight the necessity of periodic dredging and potential structural modifications to mitigate shoaling and ensure the long-term sustainability of the fishery shelter. Moreover, they emphasize the critical challenges caused by sedimentation in fishery shelters and provide data-driven recommendations for enhancing coastal engineering practices and maintenance strategies.
Exploring pore structure features, crack propagation and failure behavior of fiber reinforced foam tail fill by CT imaging and 3D reconstruction
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Jiang, Tingting; Cao, Shuai; Yılmaz, Erol
Fiber-reinforced foam tail fill (FRFTF) has been widely investigated in the field of foamed backfill because of its high strength and toughness. However, the fiber enhancement and damage mechanism of FRFTF still need to be further explored. The pore crack growth and particle structure distribution features of three kinds of basalt (B), polypropylene (PP), and glass (G) fibers on FRFTF were explored. The porosity, fracture, sphericity, and fractal dimension of FRFTF were quantitatively probed by X-ray micro-computed tomography combined with uniaxial compression (UCS) and SEM, while the spatial distribution of porosity and fracture of FRFTF was analyzed by 3D reconstruction technology. Laboratory findings demonstrate that the porosity of glass fiber increases from 1.46% to 4.74% with the increase of fiber content from 0.3% to 0.9%. This is related to the weak adhesion between the backfill and the fiber. Adding fiber and blowing agents could well enhance the pore distribution and morphology of FRFTF, reduce the number of principal cracks trapped within backfill specimens, and maintain the structure’s integrity. The relationship between FRFTF’s UCS value and porosity/fracture is closely related to the nature and quantity of fibers, and the overall performance of glass fiber is the best among others. As the quality of glass fiber shifts from 0.3% to 0.9%, the fill specimen’s UCS value is adversely correlated with the porosity. In the current study, the internal connection and damage mechanism of FRFTFs are studied microscopically. The combination of macro-mechanical strength and microscopic mechanism provides a new research idea for FRFTF materials during the implementation of the fully mechanized mining technology in hard rock mines.
Witnessing memories that are being destroyed: Challenges and staff support in psychosocial support services after the 2023 Kahramanmaraş earthquakes
(Oxford University Press, 2025) Kelebek Küçükarslan, Görkem; Albayrak, Hande; Selçuk, Ozan; Güzel, Bekir
Disasters have a profound impact on people's lives and require effective psychosocial support (PSS) services to mitigate the negative effects and accelerate recovery. The Kahramanmaraş earthquakes in Türkiye in 2023 posed major challenges for psychosocial support professionals (PSSPs). This study examines the role, challenges, and needs of PSSPs after these earthquakes and aims to find solutions to improve service delivery and professional well-being. We analysed the data thematically by conducting in-depth interviews with thirty PSSPs from nine institutions in the most affected provinces. The results show that PSSPs faced numerous challenges, including emotional distress, inadequate self-care, difficult working conditions, and lack of coordination. High expectations and experiences of traumatic events led to burnout and secondary traumatic stress. Despite various coping strategies, their effectiveness was impaired by the continuous deployment and inadequate conditions. Coordination issues led to inefficiencies, duplication of work, and feelings of professional inadequacy. The study emphasizes the need for improved coordination, structured support, and better working conditions for PSSPs. Institutional support, including supervision and self-care initiatives, is crucial to increase the effectiveness and well-being of these professionals. Targeted interventions and best practices for interprofessional collaboration can significantly improve the delivery of PSS services in disaster contexts.
Oxidative stress markers are lower in MINOCA than in MI-CAD, despite comparable inflammatory status
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Koç, Haldun; Yılmaz, Ahmet Seyda; Yanar, Karolin; Duran, Abuzer; Şahin, Müjgan Ayşenur; Öğütveren, Muhammed Mürsel; Hopaç, Yusuf
Myocardial infarction (MI) is defined as a clinical event in which myocardial damage is evidenced in the setting of myocardial ischemia. However, patients without occlusive coronary artery stenosis can also have myocardial infarction, which is titled Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA). In our study, we aimed to evaluate oxidative stress and inflammation responses between MINOCA and MI with coronary artery disease (CAD) patients. In this prospective, cross-sectional study, patients with elevated cardiac markers who were admitted to the cardiology clinic between March 2024 and May 2024 with the preliminary diagnosis of acute coronary syndrome were included. Patients were consecutively collected as those with an occlusive lesion on coronary angiography and those without. Routine blood samples and oxidative stress parameters were obtained and compared between groups. A total of 88 patients, including 44 MINOCA and 44 MI-CAD patients, were included in the study. The MINOCA group was significantly younger than the MI-CAD group (56.2 ± 12.5, vs. 64.7 ± 9.3, p: 0.001). While inflammatory parameters were similar between groups, dityrosine (5708 FU/mL (5311–6417) vs. 4488 FU/mL (3641–5238), p < 0.001), lipid hydroperoxide (3.6 nmol/mL (3.4–3.9) vs. 3.4 nmol/mL (3.1–3.9), p: 0.023), kynurenine (3814 ± 621 FU/mL vs. 3319 ± 680 FU/mL, p: 0.001), and malondialdehyde (17.4 nmol/mL (13.7–19.1) vs. 13.1 nmol/mL (12–14.9), p < 0.001) levels were higher in the MI-CAD group than in the MINOCA group. Although inflammation parameters did not differ between MI-CAD and MINOCA patients, oxidative stress parameters were higher in the MI-CAD group. Regardless of the presence and severity of inflammation, oxidative markers can help to assess the level of myocardial cell damage, risk stratification, and diagnosis of myocardial infarction.
