Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Activity concentrations of226Ra,232Th,137Cs and40K in Cystoseira barbata samples harvested from the Eastern Black Sea coast of Türkiye
(Gumushane University, 2024) Akçay, Nilay; Kobya, Ali İhsan
Macroalgae are important bioorganisms used in fish feed and food industry. In addition, macroalgae are used in studies to determine radioactive pollution levels in the seas. In this study, it was aimed to determine the activity concentrations of226Ra,232Th,137Cs and40K in Cystoseira barbata which is a brown macroalgae samples obtained from the Eastern Black Sea coast of Turkey. Gamma spectrometry analyzes of the samples were carried out with high purity germanium (HPGe) detector system in the Nuclear Physics laboratory of Recep Tayyip Erdoğan University. The average226Ra,232Th,137Cs and40K activity concentrations in the samples were found to be 11.2, 7.61, 2.74 and 690.7 Bq.kg-1, respectively. The average annual effective dose values resulting from these radionuclides were obtained as 3.14, 1.75, 0.04 and 4.28 µSv.y-1, respectively. Total annual effective dose values calculated with the contribution of all radionuclides were found to be in the range of 1.37-18.83 µSv.y-1. The calculated annual effective dose values are lower than 0.29 mSv.y-1, which is stated by UNSCEAR as the average annual effective dose received through ingestion of natural radionuclides, and the samples examined do not pose any radiological risk.
Factors affecting lung function in preschool children with a history of transient tachypnea of the newborn
(Brieflands, 2025) Çevik, İsmail; Er, İlkay; Günlemez, Ayla
Background: Transient tachypnea of the newborn (TTN) is a common cause of self-limiting respiratory distress in neonates. Increasing data suggest that TTN may be a risk factor for developing childhood wheezing attacks or asthma. Objectives: The aim was to evaluate lung functions in preschool children diagnosed with TTN in the neonatal period using an Impulse Oscillometry System (IOS) to assess the presence of respiratory morbidity and its contributing factors. Methods: In this prospective study, preschool children diagnosed with TTN in the neonatal period and healthy age-matched children were defined as the TTN group and control group, respectively. Impulse Oscillometry System values for resistance (R5- R20), reactance (X5-X20), resonant frequency (Z5), and reactance area (AX) were compared between both groups and within the TTN subgroups. Asthma diagnosis was determined following IOS testing using the Modified Asthma Predictive Index/ International Study of Asthma and Allergies in Childhood (ISAAC). Results: A total of 52 preschool children and 101 healthy controls participated in the study. R5 minus R20 was significantly higher, and X10 and X15 values were significantly lower in the TTN group compared to the controls. Additionally, higher R values and AX values were observed in TTN subgroups with a history of late preterm birth, noninvasive respiratory support, and maternal asthma. The rates of variable respiratory symptoms and ≥ 4 wheezing attacks in one year were 20.5% and 18%, respectively. By the end of the study, the rate of newly diagnosed asthma in the TTN group was 30.8%. Moreover, R values and Z5 were significantly higher, and X values were significantly lower in the TTN subgroup exposed to passive smoking (PS) compared to the TTN subgroup not exposed. Conclusions: Our study showed that preschool children diagnosed with TTN in the neonatal period may have peripheral airway obstruction, a known characteristic of asthma. In addition to TTN-related factors, exposure to cigarette smoke appears to negatively impact their lung function. These findings suggest that long-term medical care should be provided for these children.
Exploring noninfectious radiological lung findings in adult patients with primary immunodeficiency diseases
(Exon Publications, 2025) Aykan, Filiz Sadi; Çölkesen, Fatih; Evcen, Recep; Kılınç, Mehmet; Yıldız, Eray; Ergün, Ümmügülsüm Yılmaz; Arslan, Şevket
Primary immunodeficiency diseases (PIDs) show different patterns of airway involvement, particularly bronchiectasis; however, comparative studies of radiologic manifestations in patients with PIDs are scarce. Hence, the aim of this study to investigate radiologic lung findings in adult patients with PIDs and evaluate the possible relationship between clinical and immunologic features and respiratory function in these patients. In this study, the demographic and clinical characteristics, serum immunoglobulins (Ig), lymphocyte subgroups, high-resolution computed tomography (HRCT), and pulmonary function tests (PFTs) of 116 adult patients with PID were evaluated and those with and without abnormal HRCT were compared. The median age was 40 (28–48) years, and there were 51 (44%) females. Abnormal findings were detected in 55.2% of the HRCTs, but the most common findings were bronchiectasis (30.2%), bilateral involvement (73.5%), and lower lobe predominance. The median age and age of diagnosis were higher in those with HRCT findings. The obstructive pattern was the most common found in the PFTs. Forced vital capacity, maximal mid-expiratory flow at 25–75%, immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), cluster of differentiation (CD)4+ T cell, CD4+/CD8+ ratio, and class-switched memory B (cSMB) cell levels were significantly lower, whereas mortality was higher. Noninfectious pulmonary complications are among the important causes of morbidity and mortality in PID that could result in chronic lung disease despite adequate Ig therapy. Considering the extra radiation dose of HRCT, clinical findings and immunological and PFT parameters accompanying radiological features may be helpful in predicting the diagnosis; it may also be useful in determining additional treatment modalities and reducing mortality.
An example of clonal micropropagation of endemic bulbous ornamental plants: bellevalia tauri
(Academic Publishing House, 2025) Nasırcılar, Ayşe Gül; Karagüzel, Özgül; Mirici, Semra; Eren, Özkan
Bellevalia tauri Feinbrun which has great potential as an ornamental, is an endemic bulbous plant of the Asparagaceae family. This study, one of a very limited number of in vitro culture studies in Bellevalia species, investigated the in vitro clonal propagation potential of immature zygotic embryos and twin bulb scale explants of B. tauri. Surface sterilization of immature embryos was performed using commercial bleach and ethanol. In addition to these, hot water applications were also tested in bulb scale explants to overcome the heavy contamination. Both explant types were cultured in MS medium containing different ratios of BAP and NAA after sterilization. Although there was no contamination after sterilization in immature embryos, it was quite difficult to overcome contamination in bulb scale explants despite different sterilization methods. The in vitro regeneration method also differed according to the type of explant used in the study. New bulb formation was achieved by direct organogenesis from bulb scale explants and by indirect organogenesis after callus formation from cultured immature embryos. The highest callus and bulblet formation from immature embryo explant was obtained on medium supplemented with 2.0 mg L−1 BAP + 0.25 mg L−1 NAA medium. In this medium, percentage of explants forming callus and number of bulblets per explant were determined as 100% and 3.43, respectively. As a result of the chromosome analysis performed to determine whether plant growth regulators have an effect on the chromosome number and morphology of B. tauri in tissue culture, no anomalies were detected in the chromosome number and structure.
Cardiometabolic risk in non-diabetic metabolic dysfunction-associated steatotic liver disease (MAFLD) patients: insights from the triglyceride-glucose, plasma atherogenic, and cardiometabolic index
(Termedia Publishing House Ltd., 2025) Çiftel, Sedat; Çiftel, Serpil; Baykan, Ahmed R.; Cerrah, Serkan; Çiftel, Enver; Mercantepe, Filiz
Introduction: The objective of our study was to examine the correlation between hepatosteatosis and the triglyceride-glucose index (TyG), plasma atherogenic index (PAI), and cardiometabolic index (CMI) in nondiabetic patients. We also aimed to assess the usefulness of these indices in evaluating cardiometabolic risk in metabolic dysfunction-associated steatotic liver disease (MAFLD). Material and methods: This retrospective cross-sectional study included 695 individuals who did not have diabetes, with an average age of 39.8 ±11.3 years. A total of 595 individuals, comprising 359 women and 236 men, were diagnosed with MAFLD. The control group consisted of 100 individuals who did not have MAFLD. All the subjects underwent transabdominal ultrasonography, anthropometric measurements, and blood analyses. The groups were assessed based on the TyG index, PAI, and CMI. Results: TyG, PAI, and CMI were greater in patients with MAFLD than those without MAFLD. The TyG index, with a cutoff point of 8.47, excluded significant simple steatosis with a sensitivity of 65.3% and a specificity of 66.0%. The PAI and CMI cutoff values were 0.39 and 1.40, with sensitivities of 66.6% and 70.1% and specificities of 67.0% and 70.1%, respectively. The TyG index was independently associated with MAFLD (OR = 2.21, 95% CI: 1.339–3.665). Conclusions: The presence of MAFLD patients with a normal BMI and waist circumference indicates that these variables alone do not provide enough evidence for the diagnosis of MAFLD. Hence, it is advisable to incorporate the TyG index, the PAI, and the CMI into regular clinical practice to obtain a more precise and thorough evaluation of MAFLD and cardiometabolic risk.
