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Association and haplotype analysis of the PON1, ITGB3 and CYP3A4 genes, strong candidates for familial coronary artery disease susceptibility
Saydam, Faruk; Değirmenci, İrfan; Birdane, Alparslan; Özbayer, Cansu; Ulus, Taner; Özdemir, Mahmut; Ata, Necmi; Güneş, Hasan Veysi (2023)Objective: Genetic predisposition is very common among the patients with coronary artery disease (CAD), a complex and multifactorial disease. Our objective was to determine the possible association between the most ... -
The CYP2C19*2 and CYP2C19*17 polymorphisms play a vital role in clopidogrel responsiveness after percutaneous coronary intervention: A pharmacogenomics study
Saydam, Faruk; Değirmenci, İrfan; Birdane, Alparslan; Özdemir, Mahmut; Ulus, Taner; Özbayer, Cansu; Çolak, Ertuğrul; Ata, Necmi; Güneş, Hasan Veysi (Wiley, 2017)Clopidogrel inhibits platelet activation and aggregation by blocking the P2Y12 receptor. Dual antiplatelet therapy with clopidogrel and aspirin is recommended treatment by current guidelines for patients undergoing ...