Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
The effect of hippophae rhamnoides on hydroxychloroquine-induced stomatitis in rats
(BioMed Central Ltd, 2025) Dilber, Muhammet; Süleyman, Zeynep; Yücel, Nurinisa; Yazıcı, Gülce Naz; Mammadov, Renad; Baykal, Hüseyin; Süleyman, Halis
Background: Stomatitis is the most common mucosal side effect associated with Hydroxychloroquine (HCQ). Hippophae Rhamnoides (HR) is known to contain several phytonutrients, including anti-inflammatory, and antioxidant properties. This study aimed whether HR can mitigate HCQ-induced oxidative stress and inflammation in rat cheek tissue and to corroborate biochemical findings with macroscopic and histopathological evaluations.
Methods: Twenty four rats were used and split into four groups: healthy control group (HG), receiving HR alone, receiving HCQ alone, and receiving both HR and HCQ (HRHQ). The drugs were administered for 10 days, and at the end of the 10th day, the rats were euthanized with high dose of thiopental sodium anesthesia and the inner cheek tissues removed.
Results: HR decreased malondialdehyde, and pro-inflammatory cytokine levels, which increased by HCQ, while it increased anti-oxidant levels, which decreased by HCQ. The inner cheek tissue was examined macroscopically for edema, hemorrhagic cracks, hyperemia and gray appearance that developed due to HCQ use, which were alleviated with HR. Histopathologically, epithelial necrosis, muscle degeneration, scar tissue, polymorphonuclear cell (PMNL) infiltration, haemorrhage and edema were observed in the HCQ group. In contrast, in the HRHQ group, epithelial necrosis, and muscle degeneration were normal, haemorrhage was absent, PMNL infiltration persisted in some-areas, and moderate capillary congestion and dilatation were observed. detected.
Conclusion: The results indicate that HR may be a potential candidate for preventing and treating stomatitis associated with HCQ use. Translating these findings into clinical practice could support the safe and effective use of HR as a therapeutic agent.
Effects of initial periodontal treatment on heat shock protein 90 and Interleukin-1β levels in gingival crevicular fluid of stage III periodontitis patients
(BioMed Central Ltd, 2025) Çalışkan, Neslihan; Toker, Hülya; Çelik, Ayşe Büşranur; Güler, Özlem Şebnem; Al, Mervenur; Tutar, Yusuf
Aim: This study aimed to evaluate the effect of phase I periodontal therapy on interleukin-1β (IL-1β) and heat shock protein 90 (HSP90) levels in gingival crevicular fluid (GCF) of patients with stage III, grade C periodontitis.
Materials and methods: Nineteen systemically and periodontally healthy individuals and nineteen patients with stage III, grade C periodontitis were enrolled. Clinical parameters including plaque index (PI), gingival index (GI), probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL) were recorded. Three site-specific GCF samples (shallow, moderate, and deep pockets) were collected from maxillary anterior teeth of periodontitis patients. IL-1β and HSP90 levels were quantified using enzyme-linked immunosorbent assay (ELISA). Clinical measurements and GCF samples were obtained at baseline and 6 weeks after baseline following initial periodontal therapy.
Results: Periodontal therapy significantly improved clinical parameters and reduced GCF IL-1β and HSP90 levels (p < 0.05). Baseline HSP90 levels were significantly higher in moderate and deep pockets compared with healthy controls (p < 0.05). HSP90 levels in deep pockets remained significantly higher than in shallow pockets both before and after treatment (p < 0.05). A positive correlation was found between PD and IL-1β levels in moderate pockets prior to treatment (p < 0.05), and between CAL and HSP90 levels in moderate pockets both before and after treatment (p < 0.05).
Conclusion: Within the limitations of this study, GCF IL-1β and HSP90 levels were elevated in patients with stage III, grade C periodontitis compared with healthy controls, but decreased following periodontal treatment in parallel with clinical improvements. Further studies are warranted to elucidate the role of HSP90 and other heat shock proteins in periodontal disease activity and pathogenesis.
Diagnostic accuracy of point-of-care ultrasound for diverticulitis: a systematic review and meta-analysis
(BioMed Central, 2025) Çelik, Ali; Topaloğlu, Ensar; Yazıcı, Mümin Murat
Background: Diverticulitis is a common emergency department (ED) diagnosis requiring imaging for confirmation. Point-of-care ultrasound (PoCUS) has emerged as a rapid and accessible modality for evaluating acute abdominal conditions. This systematic review and meta-analysis aimed to assess the diagnostic accuracy of PoCUS in detecting acute diverticulitis. As a secondary objective, we evaluated its accuracy in diagnosing complicated diverticulitis.
Methods: We performed a systematic review and meta-analysis in accordance with PRISMA-DTA guidelines. MEDLINE, Scopus, Web of Science, and CENTRAL were searched through February 2025, and risk of bias was assessed using QUADAS-2. The reference standard was computed tomography (CT) with or without intravenous contrast or comprehensive clinical follow-up. A bivariate random-effects model was used for pooled estimates.
Results: Six studies (n = 1,420) evaluating PoCUS performed by emergency physicians or other non-radiologist clinicians were included. Pooled sensitivity and specificity of PoCUS for acute diverticulitis were 94% (95% CI: 92–95%) and 86% (95% CI: 72–94%), respectively. Emergency physician-performed PoCUS showed improved specificity (91%, 95% CI: 88–94%) with similar sensitivity (94%, 95% CI: 91–95%). For complicated diverticulitis, PoCUS demonstrated high specificity (98%, 95% CI: 97–99%) but moderate sensitivity (58%, 95% CI: 46–69%).
Conclusion: PoCUS is a highly effective diagnostic tool for diverticulitis, offering high sensitivity and specificity. It serves as a practical first-line imaging modality and may reduce reliance on CT imaging. However, due to its moderate sensitivity for complications, confirmatory imaging such as CT is recommended when complications are suspected.
Mathematical modeling of a fan heater using a three-dimensional temperature measurement system
(Nature, 2025) Samuk, Doğan Can; Çakır, Oğuzhan
Electric heaters are widely used because of their portability, rapid heating, ease of use, and reliability. The widespread use of heaters underscores the importance of selecting the appropriate heater to optimize efficiency and achieve energy savings. To this end, a three-dimensional temperature measurement system was developed to enable a more efficient and purpose-oriented heater design and production in this study. The measurement system included a novel sensor circuit capable of detecting temperature changes with a sensitivity of 0.0489 °C, utilizing a total of 81 sensor circuit boards. These sensors were arranged in a 9 × 9 matrix configuration on the xy-plane and were vertically displaced along the z-axis of the heater to facilitate the development of three-dimensional heating models. Using the heating models obtained from a fan heater in experimental studies, a mathematical model of the heater was derived. The model performance was evaluated using error-based performance metrics for five different heater configurations. Accordingly, the average mean absolute error and R2 compatibility value between the mathematical model and the measurement results for all configurations were 0.30 °C and 98.18%, respectively.
Advanced biometrical strategies for genetic analysis and heterosis assessment in maize germplasm
(BMC, 2026) Jan, Muhammad Faheem; Li, Ming; Alotaibi, Nahaa M.; Liaqat, Waqas; Maqbool, Asia; Altaf, Muhammad Tanveer; Umar, Aisha
Maize (Zea mays L.) is a cornerstone of global agriculture, contributing significantly to food security and economic stability as one of the world's most important cereal crops. Breeding programs enhancing maize productivity depend on strategically exploiting genetic variation and heterosis. This study employed biometrical approaches to analyze combining ability, heterosis, and heritability in 29 genotypes, including 9 parental lines and 20 F1 hybrids, developed through a Line x Tester mating scheme. Significant genetic variability was observed, with P4 (B73) and P1 (Zheng58) identified as superior combiners for nitrate reductase (NR) activity, glutamine synthetase (GS) activity, and grain yield. Testers P8 (Mo17) and P9 (PH4CV) exhibited strong combining abilities for NR activity, ear length, and grain yield, indicating the importance of parental selection. Additionally, hybrids P1 x P9 (Zheng58 x PH4CV) and P5 x P7 (PH6WC x 178) exhibited strong specific combining ability (SCA) effects, signifying both additive and non-additive gene actions in trait improvement. High mid-parent heterosis (MPH) and better-parent heterosis (BPH) were observed, with MPH ranging from 61.91% to 272.26% and BPH from 32.77% to 216.29% for grain yield, showing the potential for hybrid vigor. High heritability for grain yield, NR activity, and other traits suggests a strong genetic foundation for breeding. These findings highlight the integration of genetic variability, combining ability, and heterosis, optimizing hybrid performance and enhancing parental selection in future breeding programs.
