Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Multimodal treatment approaches and the role of radiotherapy in gastrointestinal tumors
(Nova Science Publishers, Inc., 2025) Rakıcı, Sema Yılmaz
Multimodal treatment approaches have revolutionized the management of tumors originating from the gastrointestinal system, particularly in locally advanced esophageal, gastroesophageal junction, and gastric cancer. Among these approaches, radiotherapy plays a crucial role in the treatment of gastrointestinal tumors, offering a non-invasive method to target cancer cells and reduce tumor burden. Radiotherapy damages the DNA inside cancer cells, causing them to die and aiding in the overall treatment strategy. For gastrointestinal tumors, the integration of radiotherapy with other treatment modalities such as surgery and chemotherapy has shown promising results in improving clinical outcomes and long-term survival rates. This combination approach aims to lower the risk of recurrence and enhance the effectiveness of treatment for patients with gastrointestinal malignancies. Today, multimodal treatment approaches are increasingly used in gastrointestinal tumors. Due to the increasing incidence of cancer, unavoidable tumor modifications, mutations and the development of resistance to cancer therapy, the need for combined therapies has increased by increasing the number of weapons to destroy tumor cells. The rationale of multimodal therapies is to create powerful combinations that can increase the effectiveness of therapeutic agents through synergistic effects.
Corrigendum to: the role of CO-RADS scoring system in the diagnosis of COVID-19 infection and its correlation with clinical signs
(Bentham Science Publishers, 2025) Çomoğlu, Şenol; Öztürk, Sinan; Topçu, Ahmet; Kulalı, Fatma; Kant, Aydın; Kostakoğlu, Uğur; Yılmaz, Gürdal
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Niraparib demonstrates therapeutic potential in multiple sclerosis through inhibition of IL-17A receptor interaction and promotion of remyelination
(American Chemical Society, 2025) Orhan, Müge Didem; Oktay, Lalehan; Çınar, Ayşe İrem; Yeşil, Aybek Kağan; Tunç, Hüseyin; Eren, Fatih; Avşar, Timuçin
IL-17A is a pro-inflammatory cytokine that significantly contributes to the pathogenesis of autoimmune diseases, including multiple sclerosis (MS). Previous studies have suggested that PARP-1 inhibitors can modulate IL-17A-mediated inflammation, prompting the investigation of Niraparib, an FDA-approved PARP-1 inhibitor, as a potential therapeutic agent for MS. In this study, we hypothesized that Niraparib could disrupt the interaction between IL-17A and its receptor, IL-17RA. To evaluate this, we employed a binary quantitative structure−activity relationship (QSAR) model against anti-inflammatory diseases, which indicated Niraparib’s potential efficacy against MS. In silico analyses were conducted to identify key interaction sites and critical amino acid residues involved in the IL-17A/IL-17RA binding. Molecular docking simulations demonstrated Niraparib’s capability to interfere with these interactions. It has demonstrated significant efficacy in inhibiting the interaction between the IL-17A ligand and its receptor via reporter assay. In vivo assessments were performed using a cuprizone-induced demyelination model. Immune profiling revealed modulation of various T cell subsets and B cells, while cytokine analysis indicated a shift in inflammatory responses. Histological evaluations confirmed reduced demyelination and enhanced remyelination in affected brain regions. These findings support Niraparib’s potential as a therapeutic option for MS, warranting further exploration of its mechanisms and clinical relevance.
Allision risk and impact analysis in recreational fishing boats using fuzzy bayesian networks and the finite element method
(Elsevier, 2025) Turna, İdris; Öztürk, Orkun Burak; Kartal, Şaban Emre; Pirim, Ahmet Emre; Kurt, Zafer
The growing popularity of recreational boating—fuelled by the promotion of boating and fishing experiences on social media - has led to a significant increase in boat purchases and maritime activities. However, many of these amateur fishers or boaters possess limited knowledge of the potential risks they may encounter while operating a boat. These risks must be addressed to ensure safe and sustainable boating activities. This study aims to evaluate and quantitatively assess the potential allision risks faced by sailors by integrating Fuzzy Bayesian Networks (FBN) with the Finite Element Method (FEM). The proposed approach is intended to identify the most influential risk factors, measure their relative impacts, and provide a systematic framework to support risk-informed decision-making in maritime safety management. The findings of the research conducted using the FBN method indicate that the two most significant root causes of accidents are sobriety and lack of experience. Furthermore, the FEM analysis demonstrated that fiberglass boats experienced higher stress and displacement under impact than oakwood boats. The implementation of these approaches facilitates enhanced risk management strategies for recreational boaters and operational guidelines for regulatory authorities and the fishing community. By promoting awareness and adherence to these guidelines, it is possible to significantly reduce the risks associated with recreational boating activities.
NAD+precursors mitigate the in vitro and in vivo reproductive defects: Limitations and possible solutions
(Elsevier, 2025) Arslan, Nazlı Pınar; Akpınar, Züleyha; Aybek, Havva; Doymuş, Meryem; Asilkan Kaldık, Gülsüm; Esim, Nevzat; Taşkın, Mesut
In mammalian cells, nicotinamide adenine dinucleotide (NAD+) participates in the regulation of diverse cellular processes such as ATP production, oxidative stress resistance, DNA repair, metabolic homeostasis, and inflammation. Due to these properties, exogenously applied NAD+precursors (nicotinic acid, nicotinamide, nicotinamide riboside, and nicotinamide mononucleotide) can protect organs and cells of mammalian against detrimental effects of various stress factors and diseases. For instance, NAD+and its precursors have critical importance for the in vivo and in vitro fertilization success of mammals. This review summarizes that the natural aging process, diseases, and toxic compounds cause the detrimental effects in the reproductive parameters of the in vivo models, such as the meiotic defects and the reductions in cellular NAD+level, mitochondrial functions, sperm and oocyte quality, blastocyst and embryo formation rate, implantation success, whereas the intragastric, intraperitoneal or oral administration of NAD+precursors prevents or attenuates these detrimental effects. Similarly, the supplementation of NAD+precursors can protect the oocytes and sperms against the cryopreservation process, aging and toxic compounds in the in vitro and also enhances blastocyst and embryo formation in vitro. This review study also revealed that the ability of NAD+precursors-loaded drug delivery systems to prevent reproductive defects has not yet been investigated in literature. Therefore, we recommend the development of NAD+precursor-loaded drug delivery systems targeting reproductive system organs and/or cell organelles (mitochondria, endoplasmic reticulum and nucleus). To achieve this, hormone receptors in testicular and ovarian cells can be targeted. Similarly, triphenylphosphonium (TPP+) can be used to specifically target mitochondria.
