Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Tea waste-derived wood vinegar as a bio-based acaricide: Toxicity, repellency and control of Polyphagotarsonemus latus (banks) on bean plants
(Elsevier, 2026) Akyazi, Rana; Soysal, Mete; Bayramoğlu, Zeynep; Soylu, Soner; Oğuz, Merve; Türkmen, Musa
Polyphagotarsonemus latus (Banks) (Acari: Tarsonemidae) is a major pest of numerous crops worldwide. Tea wood vinegar, derived from pyrolysed tea residues, is a sustainable pest management option. This study evaluated the ovicidal, adulticidal, and repellent activities of tea wood vinegar against P. latus under laboratory conditions and assessed its effect on mite populations on infested bean plants. Its chemical composition was analysed using GC-MS, and major volatile and phenolic compounds were identified. Ten vinegar concentrations (1%-20% v/v) were tested. Bioassays were conducted using a leaf-disc method with distilled water and calcium polysulphide as controls. Potted plant assays were also conducted to evaluate population suppression under controlled conditions. Egg mortality reached up to 94.95%, although higher concentrations caused phytotoxic effects. At non-phytotoxic concentrations (5-7.5%) in leaf discs, ovicidal activity remained high (49.5-69.7%), while calcium polysulphide showed low efficacy (3.95% mortality). Adult mortality reached 88-97% at 2.5-5% after 24 h, and repellency ranged from 96 to 100% at 5-7.5% after 96 h. LC50 values were 5.20% for eggs and 1.51% for adults, indicating effective control at non-phytotoxic levels. In potted plants, concentrations of 1-2.5% effectively reduced mite populations below the economic threshold without visible phytotoxicity, whereas higher concentrations resulted in complete suppression but caused leaf injury. Overall, tea wood vinegar showed measurable acaricidal, ovicidal, and repellent activity against P. latus under controlled conditions, with effects dependent on concentration.
Controlling defect passivation in polycrystalline silicon through hydrogen–dopant interactions during MW-ECR plasma treatment
(Elsevier, 2026) Ouldamer, R.; Belfennache, D.; Madi, D.; Yekhlef, R.; Fatmi, M.; Ghebouli, M.A.; Yaylacı, Murat
Hydrogen–dopant interactions play a crucial role in controlling the electrical properties of polycrystalline silicon during plasma processing. In this work, the interplay between dopant deactivation, hydrogen diffusion, and defect passivation in polycrystalline silicon is systematically investigated using microwave electron cyclotron resonance (MW-ECR) hydrogen plasma treatment. Defect passivation was evaluated from the evolution of the open-circuit voltage of n+pp.+ polycrystalline silicon structures, while dopant deactivation was independently examined by capacitance–voltage profiling of well-defined crystalline silicon junctions. Increasing the microwave plasma power markedly improved the open-circuit voltage of polycrystalline silicon, followed by saturation at high power. The electrical measurements reveal that boron deactivation in the p-type region generates active-dopant concentration gradients that favor deeper hydrogen penetration and enhance bulk and grain-boundary defect passivation. In contrast, phosphorus deactivation in the n+ region promotes the formation of electrically inactive P-H complexes, consuming mobile hydrogen and limiting its diffusion toward the bulk. Hydrogen diffusion coefficients increased from approximately 1.48 × 10–12 to 2.0 × 10–11 cm2/s as the microwave power increased from 150 to 650 W. At excessive hydrogen concentrations, molecular hydrogen accumulation and platelet formation, together with plasma-induced surface modifications, restrict further hydrogen transport and account for the observed saturation of passivation. These results demonstrate that dopant deactivation is not merely a parasitic consequence of hydrogenation but a key factor governing hydrogen transport and defect passivation in silicon. The findings provide a materials-processing framework for optimizing plasma hydrogenation conditions while preserving dopant activity and improving the electrical quality of polycrystalline silicon. The assignments to P-H complexes, molecular H₂/platelet formation, and plasma-induced defects should therefore be understood as literature-supported mechanistic interpretations of the electrical trends rather than as direct structural observations in the present samples.
The effect of e-health literacy on kidney health awareness in adolescents: A cross-sectional study
(W.B. Saunders, 2026) Altay, Gamzegül; Büyük, Nisanur
Aim The aim of this study was to identify the factors associated with adolescents' e-health literacy and to evaluate e-health literacy as a predictor of kidney health awareness. Design and methods This study is descriptive and cross-sectional. The sample consisted of 669 high school students aged 14–18 years in three public high schools in northeastern Turkey. Data were collected using the “E-Health Literacy Scale in Adolescents” and the “Kidney Health Awareness Scale in Adolescents”. Simple linear regression and multiple linear regression methods were used to analyze the data. Results The mean score of the E -Health Scale was 28.25 ± 5.65 and the mean score of the Kidney Health Awareness Scale in Adolescents was 35.33 ± 7.34. Descriptive characteristics of adolescents (age, gender, mother and father education, income level), health perceptions and internet use accounted for 15.9% of the variance in e-health literacy. Statistical analysis indicated that e-health literacy was a significant predictor of kidney health awareness (β = 0.169, p < 0.001), where higher e-health literacy scores were associated with higher kidney health awareness scores. Conclusion E -health literacy was identified as a significant statistical predictor of kidney health awareness among adolescents. These findings suggest that higher levels of e-health literacy are associated with improved awareness of kidney health. Practice implications Nurses, schools and parents have important responsibilities in improving e-health literacy and kidney health awareness of adolescents. These findings contribute to preventive health services by highlighting the relationship between e-health literacy and kidney health awareness.
Water-soluble non-peripheral quinoline-substituted Co(II) and Cu(II) phthalocyanines as promising multi-target enzyme inhibitors: synthesis, enzyme kinetics, and molecular docking studies
(Elsevier, 2026) Keleş, Turgut; Akkaya, Didem; Özel, Arzu; Aksel, Ahmet Buğra; Eyi, Tuğba; Yıldırım, Beyza Nur; Bıyıklıoğlu, Zekeriya
New non-peripherally quinoline-substituted cobalt(II) and copper(II) phthalocyanines and their quaternized water-soluble derivatives were synthesized, characterized, and investigated as multi-target enzyme inhibitors. The synthesized compounds were structurally confirmed by FT-IR, UV–Vis, NMR, ESI-MS, and MALDI-TOF MS analyses. The water-soluble derivatives, n-8K-C3-CuQ and n-8K-C3-CoQ, were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and α-glucosidase. Both compounds showed stronger AChE inhibition than galantamine, with IC₅₀ values of 1.65 ± 0.58 µM for n-8K-C3-CuQ and 1.60 ± 0.94 µM for n-8K-C3-CoQ. In BuChE inhibition, n-8K-C3-CoQ exhibited the highest activity with an IC₅₀ value of 4.71 ± 1.96 µM, markedly superior to galantamine. Moreover, both derivatives displayed pronounced α-glucosidase inhibition, with IC₅₀ values of 1.14 ± 0.85 and 1.36 ± 0.49 µM for n-8K-C3-CuQ and n-8K-C3-CoQ, respectively, compared with acarbose. Enzyme kinetic studies revealed enzyme- and metal-dependent inhibition mechanisms, including competitive, mixed-type, and non-competitive inhibition modes. Molecular docking analyses supported the experimental findings, with favorable binding scores toward AChE, BuChE, and α-glucosidase, reaching -9.0 kcal/mol. Overall, these results suggest that water-soluble quinoline-functionalized metallophthalocyanines may represent promising scaffolds for the development of multi-target cholinesterase and α-glucosidase inhibitors. However, further cytotoxicity, selectivity, and in vivo studies are required before their therapeutic potential can be fully established.
Triazole-isatin hybrids as potential dual cholinesterase inhibitors for Alzheimer’s disease: synthesis, structure-activity relationships, molecular docking and in silico ADME profiling
(Elsevier, 2026) Yılmaz, Fatih; Akyüz, Gülay; Emirik, Mustafa; Çalışkan, Nedime; Menteşe, Emre
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and cholinesterase inhibition remains the principal strategy for its symptomatic treatment. Because BuChE progressively compensates for the loss of AChE activity as the disease advances, dual AChE/BuChE inhibitors continue to attract attention. Twenty-one new hybrid molecules (6–8a-g) were synthesised by reacting 4-amino-3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-ones (3a-g) with isatin-3-imine benzoyl chlorides (5a-c), and their structures were confirmed by 1H NMR and 13C NMR spectroscopy and corroborated by elemental analysis. Cholinesterase inhibition was measured by Ellman's method against galantamine. Twenty of the twenty-one derivatives inhibited AChE more strongly than galantamine (IC50 = 72.21 ± 0.87 µM), and thirteen of the fifteen hybrids for which BuChE IC50 could be quantified were also more potent than the reference. Compound 7 g was the most potent AChE inhibitor, while 7b gave the most potent BuChE inhibition and the best balance across the two enzymes (7b: AChE IC50 = 23.97 ± 0.22 µM; BuChE IC50 = 32.69 ± 0.44 µM; 7g: AChE IC₅₀ = 21.60 ± 0.28 µM), ahead of 8d (25.87 ± 0.10 µM). Structure-activity analysis identified the triazolone C-3 substituent as a major determinant of activity, with the isatin halogen modulating the magnitude of those substituent effects. Molecular docking provided a qualitative structural rationale for the experimental findings: 7b and 7g gave highly favourable AChE docking scores (−13.85 and −13.67 kcal mol⁻¹, respectively) with hydrogen-bonding and π-π stacking interactions, while 7b also scored more favourably than galantamine against BuChE (−8.75 versus −8.22 kcal mol⁻¹). In silico ADME profiling predicted high gastrointestinal absorption but poor blood-brain barrier permeation, and only the non-benzylic methyl and phenyl derivatives satisfied every druglikeness filter, with 7b combining full compliance with the best balanced AChE/BuChE inhibition profile.
