Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Energy resource productivity and environmental quality: A quantile-on-quantile study of Latin America from 1990 to 2022
(Elsevier, 2025) Soto, Gonzalo H.; Zambrano-Monserrate, Manuel A.; Pilatin, Abdulmuttalip; Martinez-Cobas, Xavier
In this research, we explore how renewable and fossil energy resource productivity impacted environmental quality in Latin American countries from 1990 to 2022, using quantiles for analysis. Our study reveals that renewable energy productivity (RENprod) has a stronger effect in countries with a smaller ecological footprint, diminishing in impact as the footprint grows. Conversely, fossil energy productivity (FENprod) shows an opposite trend. Overall, energy productivity is more likely to benefit environmentally friendly outcomes in countries with smaller footprints at lower quantiles. However, when considering the environmental condition based on the load capacity factor (LCF), which reflects the balance between natural resource supply and consumption, RENprod and FENprod contribute to environmental harm, with renewable energy causing significantly less harm. Consequently, we suggest policy measures to encourage renewable energy supply in sectors such as industries that support economic growth. These policies aim to facilitate a shift toward greener societies with lower environmental impact in the short term, thereby mitigating harmful environmental processes.
Metal(oid) bioaccumulation, Se[sbnd]Hg balance, and human health risk assessment in anchovy (Engraulis encrasicolus) from the southern Black Sea
(Elsevier, 2025) Öğretmen, Özen Yusuf; Karslı, Barış; Emanet, Muhammet
The European anchovy (Engraulis encrasicolus) is the widely caught fish species in Türkiye, both in terms of catch volume and widespread consumption. It holds significant economic and cultural value, particularly in the Black Sea region, where it is a staple in local diets. This study aimed to assess toxic element contamination in anchovies and evaluate potential human health risks. Metal(oid) levels were analyzed in samples collected monthly over a one-year period from the southeastern Black Sea. Although concentrations varied monthly, they remained below national and international safety limits. Seasonal variations in the concentration of 15 metal(oid)s were statistically insignificant. Health risk assessments, including estimated weekly intake (EWI), target hazard quotients (THQ), and hazard index (HI), revealed no adverse effects from regular consumption. The study also noted low mercury (Hg) levels, with a selenium (Se) to mercury molar ratio above 1 during all seasons, suggesting that selenium may mitigate the toxic effects of mercury. Thus, consuming anchovies presents a favorable risk/benefit balance for health. Carcinogenic risk index (CRI) values for arsenic (As), lead (Pb), and chromium (Cr) were within acceptable thresholds. These results demonstrate that anchovies from the region are safe to eat and pose no significant health risk. Importantly, this is the first study to investigate monthly and seasonal variations in metal levels in European anchovies from the Black Sea. The findings contribute valuable data for public health assessments and support the need for continued monitoring to address environmental changes and maintain seafood safety.
Causes of diagnostic and treatment delays in locally advanced breast cancer: a nationwide multicenter survey and electronic health records analysis in Turkiye
(Oxford University Press, 2025) Karadeniz Çakmak, Güldeniz; Tali, Ufuk; Balbaloğlu, Hakan; Taşdöven, İlhan; Özkurt, Enver; Karanlık, Hasan; Zihni, İsmail; Doğan, Lütfi; Akçay, Müfide; Günay, Semra; Basım, Pelin; Küçük, G. Ozan; Pergel, Ahmet; Maralcan, Göktürk; Uğurlu, M. Ümit; Gürleyik, Günay; Akan, Arzu; Uzunkoy, Ali; Yıldırım, Emine; Köksal, Hande; Haberal, Elifcan; Gülçelik, M.Ali; Morkavuk, Barış; Kıvılcım, Taner; Uçar, B. İmge; Koçer, H. Belma; Gümüşay, Özge; Uras, Cihan; Varlı, Metin; Ersoy, Yeliz; Özçınar, Beyza; Kafadar, Tolga; Badak, Bartu; Dağ, Ahmet; Sezer, Atakan; Özkan Gürdal, Sibel; Ağcaoğlu, Orhan; Cantürk, N. Zafer; Yıldız, O. Eren; Dalcı, Kubilay; Altınok, Ayşe; Aktaş, Ayşegül; Kebudi, Abut; Dilege, Ece; Batu, H. Figen; Vural, Veli; Sakman, Gürhan; Bölükbaşı, Yasemin; Emiroğlu, Selman; Cabioğlu, Neslihan; Deniz, Oğuzhan; Filiz, A. İlker; Yıldırım, A. Cihat; Bayır, Duygu; Ölmez, Özgür; Bakkal, Bekir H.; Bahadır, Burak; Alıcıoğlu, Banu; Büyükuysal M. Çağatay; Özaydın, Yiğit; Kaya, Hamide; Bakır, Nurullah; Cömert, Mustafa; Özmen, Vahit
Delays in breast cancer (BC) diagnosis and treatment negatively impact survival outcomes. Understanding patient- and provider-related factors behind these delays is crucial. This study aimed to identify nationwide reasons for delayed diagnosis and treatment of locally advanced BC in Turkiye. A prospective, multicenter hospital-based survey was conducted across 35 institutions between 2023 and 2024. Patient- and provider-related delays were assessed via a structured 61-item face-to-face survey, supplemented by clinical data from electronic health records. Delays exceeding 3 months were clinically categorized as significant. A total of 1322 women participated from seven regions across Turkiye. Factors contributing to diagnostic delays on a national level included economic reasons (5.5%), lack of family support (3.3%), lack of knowledge (12.4%), lack of time due to household work (3.8%), difficulty in finding an appointment (6.7%), pregnancy-related reasons (1.1%), fear of losing the breast (8.9%), fear of death (9.8%), and transportation difficulties (5.1%). Provider-related delays were infrequent. About 89.3% of the patients had the initial doctor appointment and 89.6% had the first specialist consultation within one month. Treatment planning was predominantly based on a multidisciplinary team decision in 88.3% of patients. Regarding treatment initiation, 93.2% started required treatment within 1 month of decision. Patient-related factors are the major causes of diagnostic delay in Turkiye. On the other hand, from the provider's perspective, the presence of multidisciplinary teams, including dedicated breast surgeons, represents a key factor in ensuring the timely implementation of diagnostic procedures and treatment strategies.
Clinical characteristics of AATD-related COPD patients vary with age at diagnosis: data from the EARCO international registry
(BMC, 2025) Karadoğan, Dilek; Torres-Duran, Maria; Tanash, Hanan; Rodriguez-Garcia, Carlota; Jensen, Jens-Ulrik Staehr; Corsico, Angelo Guido; Lopez-Campos, Jose Luis; Chapman, Kenneth; Clarenbach, Christian; Guimaraes, Catarina; Bartosovska, Eva; Sucena, Maria; Rodriguez-Hermosa, Juan Luis; Hernandez-Perez, Jose Maria; Telatar, Tahsin Gökhan; Varol, Yelda; Özmen, İpek; Tural, Seda; Turner, Alice M.; Ellis, Paul; EARCO Study Grp
Background This study aims to evaluate the clinical characteristics of COPD patients with AATD according to their age at diagnosis. Methods Data was obtained from the European Alpha-1 Research Collaboration (EARCO) registry, an international prospective cohort study. AATD patients with COPD registered between February 2020 and October 2024 were analysed. Clinical charateristics were compared between groups, stratified by age of AATD diagnosis as follows; <45, 45-65 and >= 65 years. A multivariable logistic regression model explored factors associated with age at diagnosis. Results A total of 1,565 AATD-COPD patients were included, with 18.2% receiving an AATD diagnosis at age >= 65. In univariate comparisons according to diagnosis age revealed that the prevalence of patients with Pi*ZZ mutation was lower in the >= 65 age group (47.1%) compared to the 45-65 (65.5%) and < 45 (78.5%) age groups. In contrast, the prevalence of Pi*SZ and Pi*SS were higher in the >= 65 group compared to the younger age groups. The proportion of never-smokers was highest in the >= 65 group (39.5%), whereas only 15.3% of patients under 45 were never-smokers. Multivariate analysis showed that; compared to never-smokers, former smoking (OR: 0.08; 95% CI: 0.03-0.23) and current smoking (OR: 0.43; 95% CI: 0.27-0.70) were negatively associated with a diagnosis at age >= 65 in all sample. Compared to the Pi*ZZ genotype, among all sample, Pi*SS was associated with more than a 3-fold increased likelihood of diagnosis at age >= 65 and when considering only index cases Pi*SZ was associated with diagnosis age of >= 65 (OR: 2.01, 95%CI: 1.01-4.04). Among patients with the Pi*ZZ, current smoking was negatively associated (OR:0.24,95%CI: 0.13-0.47) with a diagnosis at age >= 65, whereas higher FEV1% and serum AAT levels were positively associated with later diagnosis. Conclusion Patients diagnosed at an older age had lower tobacco exposure and less severe disease. This suggests that subclinical symptoms may contribute to delays in diagnosis, as COPD features can be subtle or under-recognised until later in life. Our findings highlight the importance of considering AATD in all COPD patients, regardless of age, to avoid missed or delayed diagnose.
Investigation of oxidant and antioxidant parameters in fetal tissue homogenizates positive for Brucella spp
(Polish Soc Veterinary Sciences Editorial, 2025) Kızıltepe, Şemistan; Akpınar, Rahşan Koç; Kılıçoğlu, Yunus; Merhan, Oğuz; Karakurt, Emin; Bozdeveci, Arif
The aim of the study was to determine the prevalence of Brucella in aborted bovine fetuses delivered to Samsun Veterinary Control Institute in 2017-2018 from 6 provinces (Samsun, Sivas, Giresun, Tokat, Sinop, Amasya) and to measure reactive oxygen and nitrogen species and antioxidant levels in the liver of fetuses infected with Brucella. A total of 158 samples from aborted fetuses were analyzed by Real Time Polymerase Chain Reaction (Real Time PCR). Brucella abortus (B. abortus) DNA was detected in 89 (56.33%) samples. The result was negative for 69 samples (43.67%). Twenty of the samples positive for brucellosis were used as the study group, and 15 of the negative samples were selected as the control group for biochemical analyses. Nitric oxide (NO), malondialdehyde (MDA), and reduced glutathione (GSH) activities were analyzed by the spectrophotometric method. In the Brucella-positive group, malondialdehyde (MDA), nitric oxide (NO), and reduced glutathion (GSH) activity levels amounted to 3.14 f 0.33 nmol/ml, 2.24 f 0.22 nmol/ml and 5.95 f 0.44 mu g/dl of wet fetal liver tissue, respectively, whereas the values of these parameter in the control group were 0.97 f 0.11 nmol/ml,1.38 f 0.11 nmol/ml and 7.68 f 0.25 mu g/dl of wet fetal liver tissue, respectively. MDA and NO levels were higher, and reduced GSH levels were lower in Brucella-positive fetus liver tissue compared to control. In conclusion, despite all vaccination efforts, the prevalence of Brucella infection in bovines in the Central Black Sea Region remains high. It was determined that free radical levels and antioxidant activity in Brucella-positive aborted fetus liver were different from those in the control samples.
