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dc.contributor.authorMercantepe, Filiz
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorTopçu, Atilla
dc.contributor.authorYılmaz, Adnan
dc.contributor.authorTümkaya, Levent
dc.date.accessioned2020-12-19T19:41:26Z
dc.date.available2020-12-19T19:41:26Z
dc.date.issued2018
dc.identifier.citationMercantepe, F., Mercantepe, T., Topcu, A., Yılmaz, A., & Tumkaya, L. (2018). Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury. Naunyn-Schmiedeberg's archives of pharmacology, 391(9), 915–931. https://doi.org/10.1007/s00210-018-1514-4en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.urihttps://doi.org/10.1007/s00210-018-1514-4
dc.identifier.urihttps://hdl.handle.net/11436/1778
dc.descriptionMercantepe, Tolga/0000-0002-8506-1755; yilmaz, adnan/0000-0003-4842-1173en_US
dc.descriptionWOS: 000441107600003en_US
dc.descriptionPubMed: 29860655en_US
dc.description.abstractDespite the enormous advances made in the field of oncology, no solution to the side effect of nephrotoxicity caused by cisplatin used as an antineoplastic agent for approximately 40 years has yet been discovered. This study investigated the effects of cisplatin on the kidney, the damage mechanism involved, and the potential capacity of agents such as amifostine, curcumin, and melatonin to elicit a future therapeutic protocol in cisplatin-induced nephrotoxicity at the ultrastructural and molecular levels. Our study consisted of five groups: control (saline solution only; group 1), cisplatin (cisplatin only; group 2), cisplatin + amifostine (group 3), cisplatin + curcumin (group 4), and cisplatin + melatonin (group 5). Rats in all groups except the control group were administered a single intraperitoneal dose of 7.5 mg/kg cisplatin. All animals were sacrificed under anesthesia on the sixth day after cisplatin administration. Cisplatin increased serum urea and serum creatinine levels and caused an increase in tubular necrosis scores (TNS), HPS, NF-kappa B/p65, 8-OHdG, and caspase-3 expressions (p < 0.05). Additionally, we observed basal membrane thickening in glomerules, intense electron deposition in the subendothelial region, and atypical folds in podocyte pedicels. Amifostine, curcumin, and melatonin reduced the increases in serum urea and serum creatinine levels following cisplatin administration and reduced the levels of TNS, HPS, NF-kappa B/p65, 8-OHdG, and caspase-3 expressions (p < 0.05). ROS-scavenging antioxidants may be a promising means of preventing acute kidney disease in patients using cisplatin in the treatment of malignant tumors.en_US
dc.description.sponsorshipRecep Tayyip Erdogan Universitesi [TSA-2016-652, 2016] Funding Source: Medlineen_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmifostineen_US
dc.subjectCisplatinen_US
dc.subjectCurcuminen_US
dc.subjectMelatoninen_US
dc.subjectNephrotoxicityen_US
dc.titleProtective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injuryen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorMercantepe, Filiz
dc.contributor.institutionauthorMercantepe, Tolga
dc.contributor.institutionauthorTopçu, Atilla
dc.contributor.institutionauthorYılmaz, Adnan
dc.contributor.institutionauthorTümkaya, Levent
dc.identifier.doi10.1007/s00210-018-1514-4
dc.identifier.volume391en_US
dc.identifier.issue9en_US
dc.identifier.startpage915en_US
dc.identifier.endpage931en_US
dc.relation.journalNaunyn-Schmiedebergs Archives of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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