dc.contributor.author | Akyürek, E. N. | |
dc.contributor.author | Avşar, Ayşe Filiz Yavuz | |
dc.contributor.author | Ural, Ülkü Mete | |
dc.contributor.author | Kılıçarslan, Ahmet Faruk | |
dc.contributor.author | Yıldırım, Melahat | |
dc.date.accessioned | 2020-12-19T19:49:20Z | |
dc.date.available | 2020-12-19T19:49:20Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Akyürek, E.N., Avşar, A.F.Y., Ural, Ü.M., Kılıçarslan, A. & Yıldırım, M. (2017). Expression of topoisomerase II, BCL-2, and Ki-67 in ovarian cancer tissue and their effects on the development and prognosis of ovarian cancers. European Journal of Gynaecological Oncology, 38(5), 675-679. https://doi.org/10.12892/ejgo3370.2017 | en_US |
dc.identifier.issn | 0392-2936 | |
dc.identifier.uri | https://doi.org/10.12892/ejgo3370.2017 | |
dc.identifier.uri | https://hdl.handle.net/11436/2266 | |
dc.description | WOS: 000410875900004 | en_US |
dc.description.abstract | Purpose: the objective of this study was to evaluate the role of the expression of topoisomerase II, BCL-2, and Ki-67 in an ovarian tissue and their effects on the development and the prognosis of ovarian cancers. Materials and Methods: the study consisted of 38 female patients with ovarian cancers. Patients' characteristics, tumor type, stage, and the grade of the disease, and topoisomerase II, Bcl2, and Ki-67 values in ovarian tissue were compared. Results: Extensivenesses of topoisomerase II and Ki-67 staining in early -stage disease were found statistically different from those in the advanced stage diseases (for topoisomerase II, 60.38 33.87% vs 85 8.5%, p = 0.017, for Ki-67; 25.07 +/- 25.04% vs 51 +/- 25.29%,p = 0.012). Differences of Bcl-2 staining between two groups were not significant (30.38 +/- 38.82 % vs 18.2 +/- 30.58%, p = 0.377). Conclusions: Expressions of topoisomerase II and Ki-67 in ovarian cancer tissues were associated with advanced stage diseases and expression of Bcl-2 refers to good histological grade in patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | 7847050 Canada Inc | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Ovarian cancer | en_US |
dc.subject | Topoisomerase II | en_US |
dc.subject | Bcl-2 | en_US |
dc.subject | Ki-67 | en_US |
dc.subject | Cancer tissue | en_US |
dc.title | Expression of topoisomerase II, BCL-2, and Ki-67 in ovarian cancer tissue and their effects on the development and prognosis of ovarian cancers | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Akyürek, E. N. | |
dc.contributor.institutionauthor | Ural, Ülkü Mete | |
dc.identifier.doi | 10.12892/ejgo3370.2017 | |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 675 | en_US |
dc.identifier.endpage | 679 | en_US |
dc.relation.journal | European Journal of Gynaecological Oncology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |