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dc.contributor.authorYolaş, Coşkun
dc.contributor.authorÖzdemir, Nuriye Güzin
dc.contributor.authorKanat, Ayhan
dc.contributor.authorAydın, Mehmet Dumlu
dc.contributor.authorKeleş, Papatya
dc.contributor.authorKepoğlu, Ümit
dc.contributor.authorAydın, Nazan
dc.contributor.authorGündoğdu, Cemal
dc.date.accessioned2020-12-19T19:50:59Z
dc.date.available2020-12-19T19:50:59Z
dc.date.issued2016
dc.identifier.citationYolas, C., Ozdemir, N. G., Kanat, A., Aydin, M. D., Keles, P., Kepoglu, U., Aydin, N., & Gundogdu, C. (2016). Uncovering a New Cause of Obstructive Hydrocephalus Following Subarachnoid Hemorrhage: Choroidal Artery Vasospasm-Related Ependymal Cell Degeneration and Aqueductal Stenosis-First Experimental Study. World neurosurgery, 90, 484–491. https://doi.org/10.1016/j.wneu.2016.03.049en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2016.03.049
dc.identifier.urihttps://hdl.handle.net/11436/2493
dc.descriptionAYDIN, Nazan/0000-0003-3232-7713; Gundogdu, Cemal/0000-0003-2857-923X; Kanat, Ayhan/0000-0002-8189-2877en_US
dc.descriptionWOS: 000380360500060en_US
dc.descriptionPubMed: 27020981en_US
dc.description.abstractBACKGROUND: Hydrocephalus is a serious complication of subarachnoid hemorrhage (SAH). Obstruction of the cerebral aqueduct may cause hydrocephalus after SAH. Although various etiologic theories have been put forward, choroidal artery vasospasm-related ependymal desquamation and subependymal basal membrane rupture as mechanisms of aqueductal stenosis have not been suggested in the literature. METHODS: This study was conducted on 26 hybrid rabbits. Five rabbits were placed in a control group, 5 were placed in a sham group, and the remaining rabbits (n = 16) were placed in the SAH group. in the first 2 weeks, 5 animals in the SAH group died. the other 21 animals were decapitated after the 4-week follow-up period. Choroidal artery changes resulting from vasospasm, aqueduct volume, ependymal cell density, and Evans index values of brain ventricles were obtained and compared statistically. RESULTS: Mean aqueduct volume was 1.137 mm(3) +/- 0.096, normal ependymal cell density was 4560/mm(2) +/- 745, and Evans index was 0.32 +/- 0.05 in control animals (n = 5); these values were 1.247 mm(3) +/- 0.112, 3568/mm(2) +/- 612, and 0.34 +/- 0.15 in sham animals (n = 5); 1.676 mm(3) +/- 0.123, 2923/mm(2) +/- 591, and 0.43 +/- 0.09 in animals without aqueductal stenosis (n = 5); and 0.650 mm(3) +/- 0.011, 1234/mm(2) +/- 498, and 0.60 +/- 0.18 in animals with severe aqueductal stenosis (n = 6). the choroidal vasospasm index values were 1.160 +/- 0.040 in the control group, 1.150 +/- 0.175 in the sham group, 1.760 +/- 0.125 in the nonstenotic group, and 2.262 +/- 0.160 in the stenotic group. Aqueduct volumes, ependymal cell densities, Evans index, and choroidal artery vasospasm index values were statistically significantly different between groups (P<0.05). CONCLUSIONS: Ependymal cell desquamation and subependymal basal membrane destruction related to choroidal artery vasospasm may lead to aqueductal stenosis and hydrocephalus after SAH.en_US
dc.language.isoengen_US
dc.publisherElsevier Science Incen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAqueductal stenosisen_US
dc.subjectChoroidal artery vasospasmen_US
dc.subjectEpendymal cell desquamationen_US
dc.subjectHydrocephalusen_US
dc.subjectSubarachnoid hemorrhageen_US
dc.titleUncovering a new cause of obstructive hydrocephalus following subarachnoid hemorrhage: choroidal artery vasospasm-related ependymal cell degeneration and aqueductal stenosis-first experimental studyen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorKanat, Ayhan
dc.identifier.doi10.1016/j.wneu.2016.03.049
dc.identifier.volume90en_US
dc.identifier.startpage484en_US
dc.identifier.endpage491en_US
dc.relation.journalWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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