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dc.contributor.authorKurt, Aysel
dc.contributor.authorTürüt, Hasan
dc.contributor.authorAıipayam, Ahmet
dc.contributor.authorKırbaş, Aynur
dc.contributor.authorYüce, Süleyman
dc.contributor.authorCüre, Medine Cumhur
dc.contributor.authorCüre, Erkan
dc.date.accessioned2020-12-19T19:55:53Z
dc.date.available2020-12-19T19:55:53Z
dc.date.issued2016
dc.identifier.citationKurt, A., Turut, H., Acipayam, A., Kirbas, A., Yuce, S., Cure, M.C. & Cure, E. (2016). Investigation of surfactant protein-D and interleukin-6 levels in patients with blunt chest trauma with multiple rib fractures and pulmonary contusions: a cross-sectional study in Black Sea Region of Turkey. Bmj Open, 6(10). https://doi.org/10.1136/bmjopen-2016-011797en_US
dc.identifier.issn2044-6055
dc.identifier.urihttps://doi.org/10.1136/bmjopen-2016-011797
dc.identifier.urihttps://hdl.handle.net/11436/2626
dc.descriptionCure, Medine Cumhur/0000-0001-9253-6459; cure, erkan/0000-0001-7807-135Xen_US
dc.descriptionWOS: 000391303200084en_US
dc.descriptionPubMed: 27733410en_US
dc.description.abstractObjective: Multiple rib fractures (RFs) and pulmonary contusions (PCs), with resulting systemic lung inflammation, are the most common injuries caused by blunt chest trauma (BCT) in motor vehicle accidents. This study examined levels of the inflammation marker interleukin (IL)-6 and those of the acute-phase reactant surfactant protein (SP)-D in patients with BCT. Design: Prospective, cross-sectional, observational study. Setting: Single-centre, tertiary care hospital in the Black Sea Region of Turkey. Participants: the study included 60 patients with BCT who were hospitalised in our thoracic surgery department. Parameters measures: the SP-D and IL-6 serum levels of patients with RFs (two or more RFs) (n=30) and patients with PCs (n=30) were measured after 6 hours, 24 hours and 7 days, and compared with those of age-matched and gender-matched healthy participants. Results: the 6-hour serum SP-D levels of the RFs (p=0.017) and PCs (p<0.001) groups were significantly higher than those of the healthy controls. the 24-hour and 7-day SP-D levels of both groups were also higher than the control group. the serum IL-6 levels of both groups were significantly higher than those of the control group. We have found Injury Severity Score to be independently related to 6-hour IL-6 (beta=1.414, p<0.001) and 24-hour IL-6 levels (beta=1.067, p<0.001). the development of complications was independently related to 6-hour SP-D level (beta=0.211, p=0.047). Conclusions: RFs and PCs after BCT lead to local and systemic inflammation due to lung injury. the levels of the systemic inflammation marker IL-6 and those of the acute-phase reactant SP-D were elevated in the present study. the SP-D level may be used as a marker in the follow-up of BCT-related complications.en_US
dc.description.sponsorshipScientific Research Projects of Recep Tayyip Erdogan University [2013.106.02.2]en_US
dc.description.sponsorshipThis study was funded by Scientific Research Projects of Recep Tayyip Erdogan University (project number: 2013.106.02.2).en_US
dc.language.isoengen_US
dc.publisherBmj Publishing Groupen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRespiratory-distressen_US
dc.subjectGastrointestinal decontamination agentsen_US
dc.subjectAcute lung injuryen_US
dc.subjectSystemic inflammationen_US
dc.subjectN-acetlcysteineen_US
dc.subjectRatsen_US
dc.titleInvestigation of surfactant protein-D and interleukin-6 levels in patients with blunt chest trauma with multiple rib fractures and pulmonary contusions: a cross-sectional study in Black Sea Region of Turkeyen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorKurt, Aysel
dc.contributor.institutionauthorTürüt, Hasan
dc.contributor.institutionauthorKırbaş, Aynur
dc.contributor.institutionauthorCüre, Medine Cumhur
dc.contributor.institutionauthorCüre, Erkan
dc.identifier.doi10.1136/bmjopen-2016-011797
dc.identifier.volume6en_US
dc.identifier.issue10en_US
dc.ri.editoaen_US
dc.relation.journalBmj Openen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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