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dc.contributor.authorSahin, Figen Kir
dc.contributor.authorSahin, Serap Baydur
dc.contributor.authorBalik, Gulsah
dc.contributor.authorUral, Ulku Mete
dc.contributor.authorTekin, Yesim Bayoglu
dc.contributor.authorCure, Medine Cumhur
dc.contributor.authorCure, Erkan
dc.date.accessioned2020-12-19T20:03:47Z
dc.date.available2020-12-19T20:03:47Z
dc.date.issued2014
dc.identifier.issn1940-5901
dc.identifier.urihttps://hdl.handle.net/11436/3232
dc.descriptionCure, Medine Cumhur/0000-0001-9253-6459; cure, erkan/0000-0001-7807-135Xen_US
dc.descriptionWOS: 000345121100049en_US
dc.descriptionPubMed: 25419391en_US
dc.description.abstractPentraxin-3 (PTX3) a cytokine-inducible molecule is released from various tissues. Its level increases as a response to different inflammatory conditions. Polycystic Ovary Syndrome (PCOS) is considered as a proinflammatory state. the aim of this study was to investigate the association between PTX3 and various metabolic and hormonal parameters in PCOS patients. This study included 64 new diagnosed PCOS patients who had been never treated previously with PCOS and 46 healthy controls with matched age and body mass index (BMI). PTX3, biochemical and hormonal parameters of both groups were measured. the patients were divided into obese and nonobese subgroups according to BMI (above or lower than 25 kg/m(2)). PTX3, HOMA-IR and high sensitive C-reactive protein (hs-CRP) levels of these subgroups were compared. Serum PTX3 (p=0.013), hs-CRP (p=0.015) and HOMA-IR (p=0.023) levels of PCOS patients were significantly higher than the control group. Serum PTX3 has been found to have negative correlations with BMI (r=-0.318, p < 0.001), waist circumference (r=-0.306, p < 0.001), HOMA-IR (r=0.324, p < 0.001) and hs-CRP (r=-0.206, p=0.031). Subgroup analysis revealed PCOS women with obesity to have significantly higher serum PTX3 level than non-obese PCOS subjects (p=0.012), non-obese controls (p=0.015) and obese controls (p=0.002). Women with new diagnosed PCOS especially obese subjects had significantly lower serum PTX3 than the control group. PTX3 has been found to be negatively correlated with BMI and insulin resistance. Low PTX3 level may have a role in the etiology of PCOS and in the formation of atherosclerotic diseases by stimulation of chronic inflammation.en_US
dc.language.isoengen_US
dc.publisherE-Century Publishing Corpen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPentraxin-3en_US
dc.subjectpolycystic ovary syndromeen_US
dc.subjectinsulin resistanceen_US
dc.subjectobesityen_US
dc.subjectbody mass indexen_US
dc.titleDoes low pentraxin-3 levels associate with polycystic ovary syndrome and obesity?en_US
dc.typearticleen_US
dc.contributor.departmentRTEÜen_US
dc.identifier.volume7en_US
dc.identifier.issue10en_US
dc.identifier.startpage3512en_US
dc.identifier.endpage3519en_US
dc.relation.journalInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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