Increased plasminogen Activator Inhibitor-1 levels in patients wıth isolated coronary artery ectasia
Duraklıoğlugil, Murtaza Emre
Uydu, Hüseyin Avni
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CitationÇiçek, Y., Durakoğlugil, ME., Erdoğan, T., Çetin, M., Yılmaz, A., Uydu, HA., Sağlam, H. ve diğerleri. (2013). Increased plasminogen Activator Inhibitor-1 levels in patients wıth isolated coronary artery ectasia. International Journal of Cardiology, 163, S27-S27.
Background: Coronary artery ectasia (CAE) is defined as local or generalized aneurysmal dilatation of the coronary arteries. Although the etiology of CAE has not been identified completely, the most frequent cause is coronary atherosclerosis. It is known that an expansive remodelling occurs in atherosclerotic coronary arteries due to plague rupture and increased plague burden particularly in early stages. Endothelial nitric oxide synthase (eNOS) has important role in modulating smooth muscle tonus and vessel diameter. T-786 C polymorphism of the eNOS gene has been associated with altered function of this gene and its products. Experimental and clinical data suggesting that; in the absence of eNOS, endothelial functions and luminal remodeling is impaired, the vessel wall thickness is increased, atherosclerosis accelerated and got complicated. In this study, we investigated the eNOS gene polymorphism (T-786 C) in patients with CAE who live in the lakes district