Synthesis of methyl (E)-2′,4″-thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities
Künye
Usta, A., Yaşar, A., Yaylı, N., Karaoğlu, Ş.A. & Yaylı, N. (2009). Synthesis of methyl (E)-2′,4″-thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities. Turkish Journal of Chemistry, 33(5), 621-632. https://doi.org/10.3906/kim-0809-44Özet
A series of 9 new (E) -thiazachalcones (1-3), and their N -alkyl substituted derivatives (4-6), and stereoselective dimerization products (7-9) were synthesized, then tested for antimicrobial activity against all test microorganisms except Pseudomonas aeruginosa. The new compounds (1-6) without dimerization products (7-9) showed good antimicrobial property against Staphylococcus aureus, Listeria monocitogenes, and Enterococcus faecalis. The possible dimerization products of compounds (1-3) were calculated theoretically. Experimental and theoretical calculation showed that ? -truxinic type dimer is the most stable isomer. © TÜBİTAK.