Determination of the protonation constants of some 4-(substituted benzylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones by the potentiometric method in ethanol-water mixtures
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Citationİslamoğlu, F., Kahveci, B. & İslamoğlu, Y. (2007). Determination of the Protonation Constants of Some 4-(Substituted benzylamino)-4,5-dihydro1H-1,2,4-triazol-5-ones by the Potentiometric Method in Ethanol–Water Mixtures. South African Journal of Chemistry, 60, 36-41.
To gain more information about the effect of solvent on 4,5-dihydro-1H-1,2,4-triazol-5-ones, the stoichiometric protonation constants of thirteen triazoles in ethanol-water mixtures were determined at an ionic strength of 0.10MNaCl and at 25.0 ± 0.1°C under nitrogen atmosphere. A potentiometric method was used and the calculation was carried out using the PKAS computer program. The correspondingpKa values of these triazoles were determined in ethanol-water mixtures. Thus, the effects of solvent and molecular structure upon acidity were investigated. The logarithm of the protonation constants of the title 4,5-dihydro-1H-1,2,4-triazol-5-ones decreased linearly with increasing ethanol content, but the values determined with 80% ethanol did not follow this linear trend. The variation of these constants is discussed on the basis of specific solute-solvent interactions.
SourceSouth African Journal of Chemistry