dc.contributor.author | Demiryılmaz, İsmail | |
dc.contributor.author | Uzkeser, Hülya | |
dc.contributor.author | Çetin, Nihal | |
dc.contributor.author | Hacımüftüoğlu, Ahmet | |
dc.contributor.author | Bakan, Ebubekir | |
dc.contributor.author | Altuner, Durdu | |
dc.date.accessioned | 2020-12-19T20:16:15Z | |
dc.date.available | 2020-12-19T20:16:15Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Demiryilmaz, I., Uzkeser, H., Cetin, N., Hacimuftuoglu, A., Bakan, E., Altuner, D., (2013).Effect of Mirtazapine on Gastric Oxidative Stress and DNA Injury Created With Methotrexate in Rats.Asian Journal of Chemistry, 25(4), 2047-2050.https://doi.org/10.14233/ajchem.2013.13296 | |
dc.identifier.issn | 0970-7077 | |
dc.identifier.uri | https://doi.org/10.14233/ajchem.2013.13296 | |
dc.identifier.uri | https://hdl.handle.net/11436/4162 | |
dc.description.abstract | In this study, effect of mirtazapine on gastric oxidative stress and DNA injury created with methotrexate was investigated. Experimental results showed that GSH (nmol/g protein), MDA (?mol/g protein) and MPO (?/g protein) in the gastric tissue of the control group rats receiving methotrexate are 4.97 ± 0.37, 2.78 ± 0.30 and 3.12 ± 0.18, respectively. GSH, MDA and MPO measurements in the gastric tissue of rats receiving mirtazapine + methotrexate were detected to be 9.23 ± 0.51(p < 0.0001), 1.80 ± 0.31(p < 0.0001) and 1.63 ± 0.25 (p < 0.0001), respectively. GSH, MDA and MPO values in the intact rat group were found 8 ± 0.38 (p < 0,0001), 1.63 ± 0.28 (p < 0.0001) and 1.37 ± 0.21 (p < 0.0001), respectively. In addition, while 8-ohdG/dG quantity that DNA injury product in the control group administered methotrexate was 2.4 ± 0.11 pmol/L, this quantity was 1.3 ± 0.14 pmol/L (p < 0.001), 1.1 ± 0.10 pmol/L (p < 0.001) in mirtazapine and intact group, respectively. As a result, it was seen that mirtazapine prevents increase of oxidative stress and DNA injury created with methotreaxete in the gastric tissue of rat. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Chemical Publishing Co. | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | DNA Injury | en_US |
dc.subject | Methotrexate | en_US |
dc.subject | Mirtazapine | en_US |
dc.subject | Oxidative Stress | en_US |
dc.subject | Rat | en_US |
dc.title | Effect of mirtazapine on gastric oxidative stress and DNA injury created with methotrexate in rats | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Altuner, Durdu | |
dc.identifier.doi | 10.14233/ajchem.2013.13296 | |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 2047 | en_US |
dc.identifier.endpage | 2050 | en_US |
dc.relation.journal | Asian Journal of Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |