Novel fumarate derivatives synthesis and investigation of acetylcholinesterase inhibitor properties

Abstract

In this study, new fumarate compounds (I-IV) containing some natural phenols (eugenol, guaiacol, isoeugenol and vanillin) were synthesized and characterized. The single crystal X-ray diffraction technique was used to determine the crystal structures of all compounds. All compounds were evaluated as acetylcholinesterase (AChE) inhibitory, especially compound IV (IC50 = 5.25±0.51 µg/mL), can be identified as a promising anti-acetylcholinesterase agent due to its good inhibitory effect, when compared with donepezil hydrochloride (IC50 =16.02±0.66 µg/mL) as used standard acetylcholinesterase inhibitory agent.