dc.contributor.author | Mercantepe, Filiz | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Mercantepe, Tolga | |
dc.contributor.author | Rakıcı, Sema Yılmaz | |
dc.contributor.author | Çiftel, Serpil | |
dc.contributor.author | Çiftel, Sedat | |
dc.date.accessioned | 2023-08-21T06:20:42Z | |
dc.date.available | 2023-08-21T06:20:42Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Mercantepe, F., Tumkaya, L., Mercantepe, T., Rakici, S. Y., Ciftel, S., & Ciftel, S. (2023). Radioprotective effects of α2-adrenergic receptor agonist dexmedetomidine on X-ray irradiation-induced pancreatic islet cell damage. Naunyn-Schmiedeberg's archives of pharmacology, 396(8), 1827–1836. https://doi.org/10.1007/s00210-023-02454-0 | en_US |
dc.identifier.issn | 0028-1298 | |
dc.identifier.issn | 1432-1912 | |
dc.identifier.uri | https://doi.org/10.1007/s00210-023-02454-0 | |
dc.identifier.uri | https://hdl.handle.net/11436/8075 | |
dc.description.abstract | Comprehensive epidemiological analyses conducted in the last 30 years have revealed a link between radiation and DM. We aimed to determine the effects of dexmedetomidine pretreatment on radiation-induced pancreatic islet cell damage. Twenty-four rats were divided into three groups: group 1 (control group), group 2 (only X-ray irradiation group), and group 3 (X-ray irradiation + dexmedetomidine). We observed necrotic cells with vacuoles accompanying loss of cytoplasm in the islets of Langerhans, extensive edematous areas, and vascular congestions in group 2. In group 3, we observed a decrease in necrotic cells in the islets of Langerhans, and edematous areas and vascular congestion was also reduced. We determined a decrease in beta-cells, alpha-cells, and D-cells in the islets of Langerhans in group 2 compared to the control group. In group 3, beta-cells, alpha-cells, and D-cells were elevated compared to group 2. Ionizing radiation may induce DM. Dexmedetomidine appears to exert a radioprotective effect. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Beta-cell | en_US |
dc.subject | Dexmedetomidine | en_US |
dc.subject | Diabetes mellitus | en_US |
dc.subject | Pancreas | en_US |
dc.subject | X-ray irradiation | en_US |
dc.title | Radioprotective effects of alpha 2-adrenergic receptor agonist dexmedetomidine on X-ray irradiation-induced pancreatic islet cell damage | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Mercantepe, Filiz | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Mercantepe, Tolga | |
dc.contributor.institutionauthor | Rakıcı, Sema Yılmaz | |
dc.identifier.doi | 10.1007/s00210-023-02454-0 | en_US |
dc.identifier.volume | 396 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 1827 | en_US |
dc.identifier.endpage | 1836 | en_US |
dc.relation.journal | Naunyn-Schmiedeberg's Archives of Pharmacology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |