Yazar "Kalkan, Yıldıray" için listeleme
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Effects of sugammadex and rocuronium mast cell number and degranulation in rat liver
Tomak, Yakup; Yılmaz, Adnan; Bostan, Habib; Tümkaya, Levent; Altuner, Durdu; Kalkan, Yıldıray; Erdivablı, Başar (Wiley, 2012)We investigated the effect of rocuronium- and sugammadex-induced mast cell increase and degranulation in rat portal triads. Forty-two rats, in six groups, received either rocuronium 1 mg.kg -1; sugammadex 15 mg.kg -1; ... -
Effects of sugammadex on immunoreactivity of calcineurin in rat testes cells after neuromuscular block: A pilot study
Kalkan, Yıldıray; Tümkaya, Levent; Bostan, Habib; Tomak, Yakup; Yılmaz, Adnan (Springer, 2012)Reversal of neuromuscular blockage induced by steroidal neuromuscular blocking agents such as rocuronium can be achieved using normal dose of sugammadex, which has been shown to be very effective for such reversal. In this ... -
Genistein exerts neuroprotective effect on focal cerebral ischemia injury in rats
Aras, Adem Bozkurt; Güven, Mustafa; Akman, Tarık; Alaçam, Hasan; Kalkan, Yıldıray; Şilan, Coşkun; Coşar, Murat (Springer/Plenum Publishers, 2015)Brain ischemia and treatment are one of the important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most important causes of damage. Currently, there are ... -
Hepatic effects of ketamine administration for 2 weeks in rats
Kalkan, Yıldıray; Tomak, Yakup; Altuner, Durdu; Tümkaya, Levent; Bostan, Habib; Yılmaz, Adnan; Ünal, D.; Kara, A.; Turan, A. (Sage Publishing, 2014)The aim of the present study was to investigate the long-term and high-dose application of ketamine on the liver by employing histologic and biochemical methods. A total of 30 male rats were randomly assigned to control ... -
High dose zoledronic acid increases ischemia-reperfusion damage of the liver
Aydın, İbrahim; Şehitoğlu, İbrahim; Özer, Emel; Kalkan, Yıldıray; Tümkaya, Levent; Cüre, Medine Cumhur; Cüre, Erkan (Verduci Publisher, 2021)OBJECTIVE: Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, has been reported to exhibit a protective effect against cancers and prevent bone fractures. It also induces apoptosis by increasing proinflammatory ... -
Histopathological effects of intramuscular metamizole sodium on rat sciatic nerve
Emir, Abdurrahman; Kalkan, Yıldıray; Bostan, Habib (Mashhad Univ Med Sciences, 2016)Objective(s): We investigated the histopathological effects of metamizole sodium (MS) on the sciatic nerve. Materials and Methods: This study was performed using 48 adult male Wistar albino rats. Ten groups were constituted ... -
Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats
Kara, Adem; Akman, Sümeyra; Özkanlar, Seçkin; Tozoğlu, Ümmühan; Kalkan, Yıldıray; Çanakcı, Cenk Fatih; Tozoğlu, Sinan (Elsevier, 2013)Melatonin is an important antioxidant, and through its anti-inflammatory effects it can control immune responses, oxidative stress, and defense cell infiltration. Periodontitis is a disease of the oral cavity and the ... -
Infliximab modulates cisplatin-induced hepatotoxicity in rats
Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Kırbaş, Aynur; Tümkaya, Levent; Yılmaz, Arif; Türkyılmaz, Ayşegül Küçükali; Sehitoğlu, İbrahim; Yüce, Süleyman (Galenos Publ, 2016)Background: Cisplatin (Cis) is one of the most com-monly used antineoplastic drugs. It is used as chemo-therapy for many solid organ malignancies such as brain, neck, male and female urogenital, vesical and pulmonary ... -
Influence of infliximab pretreatment on ischemia/reperfusion injury in rat intestine
Akdoğan, Remzi Adnan; Kalkan, Yıldıray; Tümkaya, Levent; Alacam, Hasan; Erdivanlı, Başar; Aydın, İbrahim (Via Medica, 2014)The Pringle maneuver is used in hepatic surgery to prevent blood loss but is associated with ischemia-reperfusion injury. To investigate the effect of infliximab on inflammation and apoptosis in rat intestinal mucosa during ... -
Is resveratrol a potential substitute for leuprolide acetate in experimental endometriosis?
Tekin, Yeşim Bayoğlu; Güven, Süleyman; Kırbaş, Aynur; Kalkan, Yıldıray; Tümkaya, Levent; Güven, Emine Seda Güvendağ (Elsevier Science Bv, 2015)Objective: Resveratrol, a phytoalexin polyphenol, has anti-angiogenic, antioxidant, anti-inflammatory properties. We aimed to compare the anti-inflammatory and anti-angiogenic effects of resveratrol and leuprolide acetate ... -
Lasting hepatotoxic effects of prenatal mobile phone exposure
Yılmaz, Adnan; Tümkaya, Levent; Akyıldız, Kerimali; Kalkan, Yıldıray; Bodur, Ali Fuat; Sargın, Fatma; Efe, Hasan; Uydu, Hüseyin Avni; Yazıcı, Zihni Açar (Taylor & Francis Ltd, 2017)Objective: in this study, the livers of rats born to mothers exposed to electromagnetic field (EMF) were examined 60 days postpartum for biochemical and histopathological changes.Methods: Pregnant rats were exposed to ... -
Mobile phone radiation during pubertal development has no effect on testicular histology in rats
Tümkaya, Levent; Kalkan, Yıldıray; Baş, Orhan; Yılmaz, Adnan (Sage Publications Inc, 2016)Mobile phones are extensively used throughout the world. There is a growing concern about the possible public health hazards posed by electromagnetic radiation emitted from mobile phones. Potential health risk applies ... -
The neuroprotective effect of glycyrrhizic acid on an experimental model of focal cerebral ischemia in rats
Akman, Tarık; Güven, Mustafa; Aras, Adem Bozkurt; Özkan, Adile; Sen, Halil Murat; Okuyucu, Ali; Kalkan, Yıldıray; Şehitoğlu, İbrahim; Şilan, Coşkun; Coşar, Murat (Springer/Plenum Publishers, 2015)Cerebral ischemia is still one of the most important topics in neurosciences. Our study aimed to investigate the neuroprotective and anti-oxidant effects of glycyrrhizic acid on focal cerebral ischemia in rats. Twenty-four ... -
Neuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia
Güven, Mustafa; Aras, Adem Bozkurt; Akman, Tarık; Şen, Halil Murat; Özkan, Adile; Salis, Osman; Şehitoglu, İbrahim; Kalkan, Yıldıray; Şilan, Coşkun; Deniz, Mustafa; Coşar, Murat (Mashhad Univ Med Sciences, 2015)Objective(s): Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. Material and Methods: Rats were randomly divided into ... -
Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats
Aras, Adem Bozkurt; Güven, Mustafa; Akman, Tarık; Özkan, Adile; Şen, Halil Murat; Düz, Uğur; Kalkan, Yıldıray; Coşkun, Şilan; Coşar, Murat (Shenyang Editorial Dept Neural Regeneration Res, 2015)Daidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery occlusion were intraperitoneally ... -
Neurotoxicity of various root canal sealers on rat sciatic nerve: an electrophysiologic and histopathologic study
Kılkış, Buket Tuğ; Er, Kürşat; Taşdemir, Tamer; Yıldırım, Mehmet; Taşkesen, Fatih; Tümkaya, Levent; Kalkan, Yıldıray; Serper, Ahmet (Springer Heidelberg, 2015)Objectives the aim of this study was to compare the neurotoxicity of various root canal sealers on rat sciatic nerve by electrophysiologic and histopathologic analyses. Materials and methods A total of 40 male rats were ... -
A novel model approach for esophageal burns in rats: a comparison of three methods
Kalkan, Yıldıray; Tümkaya, Levent; Akdoğan, Remzi Adnan; Yücel, Ahmet Fikret; Tomak, Yakup; Şehitoğlu, İbrahim; Pergel, Ahmet; Kurt, Aysel (Sage Publications Inc, 2015)Background: Corrosive esophageal injury causes serious clinical problems. We aimed to create a new experimental esophageal burn model using a single catheter without a surgical procedure. Materials and methods: We conducted ... -
Numerical analysis of age and gender-dependent neuronal cells in postnatal development of rat hippocampus
Kalkan, Yıldıray; Ünal, Bünyamin; Keleş, Osman Nuri; Kara, Adem (0-Belirlenecek, 2013)The hippocampus, phylogenetically one of the most ancient parts of the central nervous system, is both a highly developed structure of the mammalian brain that plays a role in complex brain functions and one of the brain ... -
The protective effect of adalimumab on renal injury in a model of abdominal aorta cross-clamping
Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Tümkaya, Levent; Aydın, İbrahim; Kırbaş, Aynur; Efe, Hasan; Kurt, Aysel; Yüce, Süleyman (Wroclaw Medical Univ, 2016)Background. Adalimumab (ADA) is a potent inhibitor of tumor necrosis factor (TNF-alpha). ADA treatment suppresses proinflammatory cytokines, leading to a decrease or inhibition of the inflammatory process. Objectives. the ...