Design, synthesis, and characterization of some new benzimidazole derivatives and biological evaluation

Abstract

A new series of benzimidazole derivatives (1-15) containing 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole, and thiazolidinon rings have been synthesized. All new synthesized benzimidazole compounds were confirmed by H-1 NMR, C-13 NMR spectra, and LC-MS, and they were examined for their antioxidant and antimicrobial activities. Compounds 7 and 1 showed the highest and the lowest antioxidant activities, respectively. the lowest minimum inhibition concentration value found in compound 5 against Enterobacter aerogenes.