Synthesis of some new Methoxy Bridged Benzimidazolyl-Substituted phthalocyanines as potent inhibitors of urease
Citation
Demirbaş, Ü., Menteşe, E., Sökmen, B.B., Bayrak, R. & Akçay, H.T. (2018). Synthesis of some new Methoxy Bridged Benzimidazolyl-Substituted phthalocyanines as potent inhibitors of urease. Journal of Organometallic Chemistry, 873, 86-90. https://doi.org/10.1016/j.jorganchem.2018.08.001Abstract
In this study, the novel peripherally 4-[(2-methyl-1H-benzimidazol-1-yl)methoxy] substituted Zn(II) (3) Cu(II) (4), Co(II) (5) phthalocyanines were prepared and their structures were characterized spectro-scopically. the light absorption behaviors of the synthesized compounds (3-6) were studied by UV-Vis spectroscopy in the different concentration and different solvents were studied also. in addition, the urease inhibition activities of the synthesized compounds were also investigated. Among the synthesized molecules, compound 5 showed the best inhibitory effect against jack bean urease with IC50 values of 0.0034 +/- 0.0010 mu M. (C) 2018 Elsevier B.V. All rights reserved.
