dc.contributor.author | Kanbolat, Şeyda | |
dc.contributor.author | Korkmaz, Nuriye | |
dc.contributor.author | Şener, Sıla O. | |
dc.contributor.author | Badem, Merve | |
dc.contributor.author | Çolak, Nevin Ulaş | |
dc.contributor.author | Abudayyak, Mahmoud | |
dc.contributor.author | Aliyazıcıoğlu, Rezzan | |
dc.contributor.author | Özgen, Ufuk | |
dc.contributor.author | Kandemir, Ali | |
dc.contributor.author | Karaoğlu, Şengül Alpay | |
dc.date.accessioned | 2020-12-19T19:42:30Z | |
dc.date.available | 2020-12-19T19:42:30Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Kanbolat, S., Korkmaz, N., Sener, S. O., Badem, M., Colak, N. U., Abudayyak, M., Aliyazicioglu, R., Ozgen, U., Kandemir, A., & Karaoglu, S. A. (2018). Antioxidant, Antimicrobial, Cytotoxic, Anticholinesterase, Antityrosinase Activities and Characterisation of Volatile Compounds of Verbascum oocarpum by SPME and GC-FID/MS. Journal of Pharmaceutical Research International, 24(4), 1–12. https://doi.org/10.9734/JPRI/2018/45242 | en_US |
dc.identifier.issn | 2456-9119 | |
dc.identifier.uri | https://doi.org/10.9734/JPRI/2018/45242 | |
dc.identifier.uri | https://hdl.handle.net/11436/1920 | |
dc.description | WOS: 000454630200005 | en_US |
dc.description.abstract | The objective of present study was to specify the antioxidant, antimicrobial, cytotoxic, anticholinesterase, and antityrosinase activities of Verbascum oocarpum Murb., together with its volatile components. the methanolic and aqueous extracts of aerial parts of V. oocarpum indicated substantial antioxidant activity derived from benzoic acid, sinapic acid, and quercetin compounds. the methanolic extract displayed moderate antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, and Mycobacterium smegmatis. It also exhibited a higher IC50 value on tyrosinase than kojic acid, and lower acetylcholinesterase and butyrylcholinesterase inhibitor activities than galantamin. MTT analysis revealed that high concentrations of V. oocarpum extract can result in cytotoxicity, with an IC50 of 0.444 mg/mL. Common volatile components included pentadecane, hex-2(E)-enal, limonene, phenylacetaldehyde, isophorone, 1-methoxy-4-(2-propenyl)-benzene, 5,6,7,7a-tetrahydro-4,4,7a-trimethyl-2(4h)-benzofuranone and hexadecane. V. oocarpummay be of potential benefit to the food, cosmetical, and pharmaceutical sectors owing to its potent anticholinesterase, antioxidant, and antimicrobial activities, volatile components, and limited cytotoxicity. | en_US |
dc.description.sponsorship | Turkish Scientific and Technical Research Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) | en_US |
dc.description.sponsorship | Sila Ozlem Sener, Merve Badem and Nuriye Korkmaz would like to acknowledge the scholarship during their postgraduate program provided by the Turkish Scientific and Technical Research Council (TUBITAK). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Sciencedomain Int | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Antimicrobial | en_US |
dc.subject | Volatile components | en_US |
dc.subject | Verbascum oocarpum | en_US |
dc.title | Antioxidant, antimicrobial, cytotoxic, anticholinesterase, antityrosinase activities and characterisation of volatile vompounds of verbascum oocarpum by SPME and GC-FID/MS | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Biyoloji Bölümü | en_US |
dc.contributor.institutionauthor | Karaoğlu, Şengül Alpay | |
dc.identifier.doi | 10.9734/JPRI/2018/45242 | |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 4 | en_US |
dc.relation.journal | Journal of Pharmaceutical Research International | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |