Synthesis and antimicrobial activity of some new triazole bridged benzimidazole substituted phthalonitrile and phthalocyanines

Abstract

In this study, some new phthalonitriles and metallophthalocyanines (Zn, Ni, Co, and Cu) containing triazole bridged benzimidazole moieties were synthesized starting from 2-(3-methylbenzyl)-1H-benzimidazole Newly synthesized compounds have been tested for their antimicrobial effects against four Gram positively (Bacillus cereus 702 Roma, B. megaterium DSM-32, B. subtilis ATCC 6633, and Staphylococcus aureus ATCC 25923) and four Gram negatively (Escherichia coli ATCC 25922, Enterobacter cloaceae ATCC 13047, Pseudomonas aeruginosa ATCC 27853, and Yersinia pseudotuberculosis ATCC 911) bacteria. According to results, compounds 6, 7b, 7c, and 8a have the best activity with MIC values of 31.25 mu g/mL to B. subtilis. the second best activity belongs to compounds 4, 5, 7, 8, 7a, 8c, and 8d with the MIC value of 62.5 mu g/mL on the same bacterium. Zinc (II) phthalocyanines have better antimicrobial activity than other metallophthalocyanines against Gram (+) bacteria.