dc.contributor.author | Bilir, Cemil | |
dc.contributor.author | Yusufoğlu, Baran | |
dc.contributor.author | Kızılkaya, Bayram | |
dc.contributor.author | Engin, Hüseyin | |
dc.date.accessioned | 2020-12-19T19:42:45Z | |
dc.date.available | 2020-12-19T19:42:45Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Bilir, C., Yusufoğlu, B., Kızılkaya, B. & Engin, H. (2018). Prognostic Value of Pre- and Posttreatment PET/CT Parameters in Patients Diagnosed with Advanced Stage NSCLC. Current Medical Imaging Reviews, 14(4), 621-628. https://doi.org/10.2174/1573405613666170322155601 | en_US |
dc.identifier.issn | 1573-4056 | |
dc.identifier.issn | 1875-6603 | |
dc.identifier.uri | https://doi.org/10.2174/1573405613666170322155601 | |
dc.identifier.uri | https://hdl.handle.net/11436/1952 | |
dc.description | WOS: 000438245400018 | en_US |
dc.description.abstract | Background: PET imaging involves several parameters. However, it is not well known which parameters in each measurable site of tumors may have a greater effect on oncologic outcomes. Method: This study included a total of 42 patients diagnosed with histology-proven NSCLC. Baseline and consecutive FDG-PET scans were carried out 3 weeks before and at least 3 months after treatment, respectively. Results: According to the PERCIST, 9 (21%) patients had Complete Response (CR), and 3 of them underwent surgical resection. Sixteen patients (38%) had Partial Response (PR), and 4 (9.5%) had Stable Disease (SD), the remaining 15 (35%) had Progressive Disease (PD). Patients who responded to the treatment had significantly higher Overall Survival (OS) and Progression Free Survival (PFS), 15 versus 9.5 months and 10 versus 6 months, respectively. the SUVmax values decreased from 12.2 to 3.7 (P=<0.001), and the mediastinal lymph nodes SUVmax decreased from 6 to 0 (P=<0.001) in the responder group. the median TLG of the primary lesion showed a statistically significant decrease from 279 to 13.6 (P=0.0001), the median TLG of the mediastinal lymph nodes decreased from 13.2 to 0 (P=0.04), and the median Whole Body (WB) TLG decreased from 338 to 17 (P=0.002) in the responder group. the posttreatment WB TLG was significantly correlated with OS and PFS. Conclusion: This study showed that the posttreatment WB TLG is significantly associated with oncologic outcomes. the metabolic changes in the mediastinal lymph nodes, as shown by the SUVmax and TLG, have a prognostic value in patients who develop new metastases during treatment. Further study in a homogenous NSCLC population can help increase our understanding of the prognostic value of PET/CT parameters. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Bentham Science Publ Ltd | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Lung cancer | en_US |
dc.subject | Survival | en_US |
dc.subject | PET/CT | en_US |
dc.subject | SUV | en_US |
dc.subject | Total lesion glycolysis | en_US |
dc.subject | Histology-proven NSCLC | en_US |
dc.title | Prognostic value of pre- and posttreatment PET/CT parameters in patients diagnosed with advanced stage NSCLC | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Yusufoğlu, Baran | |
dc.contributor.institutionauthor | Kızılkaya, Bayram | |
dc.identifier.doi | 10.2174/1573405613666170322155601 | |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 621 | en_US |
dc.identifier.endpage | 628 | en_US |
dc.relation.journal | Current Medical Imaging Reviews | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |