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Pazopanib-induced hepatotoxicity in an experimental rat model

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Date

2018

Author

Çetin, Bülent
Yılmaz, Güldal Esendağlı
Armağan, Berkan
Afşar, Barış
Demirci, Umut
Gülbahar, Özlem
Gümüşsoy, Özge
Bilgetekin, İrem
Özet, Ahmet
Üner, Aytuğ

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Cetin, B., Yılmaz, G. E., Armagan, B., Afsar, B., Demirci, U., Gulbahar, O., Gumusay, O., Bilgetekin, I., Ozet, A., & Uner, A. (2018). Pazopanib-Induced Hepatotoxicity in an Experimental Rat Model. Chemotherapy, 63(1), 39–45. https://doi.org/10.1159/000481795

Abstract

Pazopanib is an effective treatment for advanced renal cell carcinoma and soft tissue sarcoma. Besides classical adverse events of this drug class, hepatotoxicity has been described as a frequent side effect. the aim of the present study was to evaluate the effect of pazopanib on the liver in an experimental rat model. Sixteen Wistar albino rats were divided into 3 groups: experimental toxicity was induced with pazopanib (10 mg/kg) administered for 28 days (group 2) or 56 days (group 3) orally by gavage. Group 1 (control group) received only distilled water. Rats in groups 2 and 3 were sacrificed after the collection of blood and tissue samples on the 28th and 56th days, respectively. We found significant differences in bilirubin, alkaline phosphatase, lactate dehy- drogenase, glucose, triglyceride, very-low-density lipoprotein, and iron values (p < 0.050 for all) but none in any other parameter (p > 0.050). All rats in the control group had normal histological features; however, none of the rats in groups 2 and 3 showed normal histology. in group 2, we observed mild sinusoidal dilatation, congestion, enlarged Kupffer cells, accumulation of yellow-brown-black pigment in the Kupffer cells and the accumulation of hemosiderin with Prussian blue reaction in the hepatocytes. in group 3, the findings mentioned above were more prominent, and besides these findings focal acinar transformation and macrovesicular steatosis were also observed. in group 3, mild inflammation within the portal areas was observed consisting of lymphocytes, neutrophils, and eosinophils. This study is the first that reports the biochemical and histopathological evaluation of pazopanib-related hepatic toxicity. (C) 2018 S. Karger AG, Basel

Source

Chemotherapy

Volume

63

Issue

1

URI

https://doi.org/10.1159/000481795
https://hdl.handle.net/11436/1977

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  • PubMed İndeksli Yayınlar Koleksiyonu [2443]
  • Scopus İndeksli Yayınlar Koleksiyonu [6026]
  • TF, Dahili Tıp Bilimleri Bölümü Koleksiyonu [1573]
  • WoS İndeksli Yayınlar Koleksiyonu [5260]



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