Synthesis of novel pyrazolines, their boron-fluorine complexes, and investigation of antibacterial, antioxidant, and enzyme inhibition activities
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2017Author
Kahriman, NuranHaşimoğlu, Zeynep
Serdaroğlu, Vildan
Beriş, Fatih Şaban
Barut, Burak
Yaylı, Nurettin
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Kahriman, N., Haşimoğlu, Z., Serdaroğlu, V., Beriş, F. Ş., Barut, B., & Yaylı, N. (2017). Synthesis of Novel Pyrazolines, Their Boron-Fluorine Complexes, and Investigation of Antibacterial, Antioxidant, and Enzyme Inhibition Activities. Archiv der Pharmazie, 350(2), 10.1002/ardp.201600285. https://doi.org/10.1002/ardp.201600285Abstract
3,5-disubstituted-2-pyrazoline derivatives (4-6), their boron-fluorine complexes (boron (3-(2'-aminophenyl), 5-(2'-/3'-/4'-pyridyl) pyrazoline, BOAPPY) (7-9) and boron 1,2'-diazaflavone complex (BODAF) (11) were synthesized starting from azachalcones (1-3) to diazaflavone (10), respectively. Biological evaluation of compounds 4-9 and 11 showed remarkable antioxidant, antibacterial, and acetylcholinesterase and tyrosinase enzyme inhibition activities. All newly synthesized compounds 4-9 and 11 showed respectable antibacterial effect with minimum inhibitory concentrations in the range of 4.7-150mg/mL.