dc.contributor.author | İnce, İlker | |
dc.contributor.author | Aksoy, Mehmet | |
dc.contributor.author | Ahıskalıoğlu, Ali | |
dc.contributor.author | Çömez, Mehmet | |
dc.contributor.author | Dostbil, Ayşenur | |
dc.contributor.author | Çelik, Mine | |
dc.contributor.author | Yılmaz, İsmail | |
dc.contributor.author | Mammadov, Renad | |
dc.contributor.author | Doğan, Hasan | |
dc.contributor.author | Özgermen, Boztok | |
dc.contributor.author | Altuner, Durdu | |
dc.date.accessioned | 2020-12-19T19:57:04Z | |
dc.date.available | 2020-12-19T19:57:04Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Ince, I., Aksoy, M., Ahiskalioglu, A., Comez, M., Dostbil, A., Celik, M., Yilmaz, I., Mammadov, R., Dogan, H., Boztok Ozgermen, B., & Altuner, D. (2015). A Comparative Investigation of the Analgesic Effects of Metamizole and Paracetamol in Rats. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 28(3), 173–180. https://doi.org/10.3109/08941939.2014.998798 | en_US |
dc.identifier.issn | 0894-1939 | |
dc.identifier.issn | 1521-0553 | |
dc.identifier.uri | https://doi.org/10.3109/08941939.2014.998798 | |
dc.identifier.uri | https://hdl.handle.net/11436/2812 | |
dc.description | Dogan, Hasan/0000-0002-5232-4336; Ahiskalioglu, Ali/0000-0002-8467-8171; Ahiskalioglu, Ali/0000-0002-8467-8171; BOZTOK OZGERMEN, Basak/0000-0003-1264-3962; AKSOY, Mehmet/0000-0003-0867-8660 | en_US |
dc.description | WOS: 000357856500008 | en_US |
dc.description | PubMed: 26065593 | en_US |
dc.description.abstract | Background: This study investigated the effects of metamizole and paracetamol on pain and oxidative stress induced by scalpel incision and carrageenan in rats. Materials and methods: Total of 144 rats were divided into groups of 12 animals. Six groups each were used for scalpel incision and carrageenan tests. Pain was inflicted by applying a scalpel incision or carrageenan. Pain-created groups by scalpel incision received metamizole (SIM) or paracetamol (SIP) at doses of 250 or 500 mg/kg. Pain-created groups by carrageenan received metamizole (CAM) or paracetamol (CAP) at doses of 250 or 500 mg/kg. Analgesic activity was determined by Basile Algesimeter. the COX-2 and MPO gene expressions were determined, and malondialdehyde and tGSH were measured in rat paws. Results: in the scalpel incision test, pain was reduced in groups of SIM-250 and SIM-500 in the first hour by 65.2% and 91.3%, respectively, and in the third hour by 51.9% and 77.8%, respectively, compared with the SIC group. in SIP-250 and SIP-500 groups, pain was reduced in the first hour by 43% and 74%, respectively, and by 33.4% and 59.3%, respectively, in the third hour compared with the SIC group. in the carrageenan test, in groups CAM-250 and CAM-500, pain was reduced in the first hour by 72.3% and 86.1%, respectively, and by 65.8% and 71.4%, respectively, in the third hour compared with the CCG group. in groups CAP-250 and CAP-500, pain was reduced in the first hour by 52.8% and 69.4%, respectively, and by 28.6% and 25.8%, respectively, in the third hour compared with the CCG group. Metamizole inhibited COX-2 gene expression at a dose of 500 mg/kg in the carrageenan test. At doses of 250 and 500 mg/kg, metamizole reduced COX-2 and MPO gene expressions and oxidative stress induced by scalpel incision or carrageenan. But both doses of paracetamol were unable to suppress that parameters. Conclusions: Our results show that metamizole is more effective than paracetamol for treating surgical trauma-related pain, inflammation, and oxidative stress and hence may be a preferential drug to paracetamol. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Informa Healthcare | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Metamizole | en_US |
dc.subject | Paracetamol | en_US |
dc.subject | Pain | en_US |
dc.subject | Analgesia | en_US |
dc.subject | Rats | en_US |
dc.subject | Carrageenan | en_US |
dc.title | A comparative investigation of the analgesic effects of metamizole and paracetamol in rats | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Altuner, Durdu | |
dc.identifier.doi | 10.3109/08941939.2014.998798 | |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 173 | en_US |
dc.identifier.endpage | 180 | en_US |
dc.relation.journal | Journal of Investigative Surgery | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |