dc.contributor.author | Polat, Bülent | |
dc.contributor.author | Süleyman, Halis | |
dc.contributor.author | Şener, Ebru | |
dc.contributor.author | Akçay, Fatih | |
dc.date.accessioned | 2020-12-19T19:57:45Z | |
dc.date.available | 2020-12-19T19:57:45Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Polat, B., Suleyman, H., Sener, E., & Akcay, F. (2015). Examination of the effects of thiamine and thiamine pyrophosphate on Doxorubicin-induced experimental cardiotoxicity. Journal of cardiovascular pharmacology and therapeutics, 20(2), 221–229. https://doi.org/10.1177/1074248414552901 | en_US |
dc.identifier.issn | 1074-2484 | |
dc.identifier.issn | 1940-4034 | |
dc.identifier.uri | https://doi.org/10.1177/1074248414552901 | |
dc.identifier.uri | https://hdl.handle.net/11436/2883 | |
dc.description | WOS: 000349248100011 | en_US |
dc.description | PubMed: 25316705 | en_US |
dc.description.abstract | Background and Purpose: To investigate the effect of thiamine and thiamine pyrophosphate on doxorubicin-induced cardiotoxicity biochemically and histopathologically and to examine whether doxorubicin cardiotoxicity is related to the conversion of thiamine into thiamine pyrophosphate and inhibition of thiamine pyrophosphokinase (TPK) enzyme. Experimental Approach: A total of 48 Albino Wistar male rats were used. Rats were divided into groups as thiamine + doxorubicin (TIA + DOX), thiamine pyrophosphate + doxorubicin (TPP + DOX), DOX, and healthy (HEA) groups. One hour after the administration of thiamine and TPP in 25 mg/kg doses, 5 mg/kg doxorubicin were injected to all groups except HEA group during 7 days. Then, the samples were collected for biochemical (glutathione [GSH], malondialdehyde [MDA], DNA damage, creatine kinase (CK), CK-MB, and troponine I [TP-I]), molecular (TPK), and histopathological examinations. Key Results: Oxidant parameters (MDA and DNA damage) decreased and antioxidant parameter (GSH) increased in TPP + DOX group. in addition, levels of CK, CK-MB, and TP-I were low in the TPP + DOX group and high in the TIA + DOX and DOX groups. Cardiac tissue was protected in TPP + DOX group, and no protective effect was observed in TIA + DOX and DOX groups. Messenger RNA expression of TPK was decreased in DOX and TIA + DOX groups. Conclusion and Implications: the cardiotoxic effect of doxorubicin originated from the inhibition of TPK enzyme resulting in insufficient production of thiamine pyrophosphate. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Sage Publications Inc | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Cardiotoxicity | en_US |
dc.subject | Doxorubicin | en_US |
dc.subject | Thiamine | en_US |
dc.subject | Thiamine pyrophosphate | en_US |
dc.subject | Thiamine pyrophosphokinase | en_US |
dc.title | Examination of the effects of thiamine and thiamine pyrophosphate on doxorubicin-induced experimental cardiotoxicity | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Süleyman, Halis | |
dc.identifier.doi | 10.1177/1074248414552901 | |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 221 | en_US |
dc.identifier.endpage | 229 | en_US |
dc.relation.journal | Journal of Cardiovascular Pharmacology and Therapeutics | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |