dc.contributor.author | Cüre, Medine Cumhur | |
dc.contributor.author | Cüre, Erkan | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Kalkan, Yıldıray | |
dc.contributor.author | Aydın, İlkyaz | |
dc.contributor.author | Kırbaş, Aynur | |
dc.contributor.author | Efe, Hasan | |
dc.contributor.author | Şehitoğlu, İbrahim | |
dc.contributor.author | Yüce, Süleyman | |
dc.date.accessioned | 2020-12-19T19:58:30Z | |
dc.date.available | 2020-12-19T19:58:30Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Cure, M.C., Cure, E., Tumkaya, L., Aydin, I., Kirbas, A., Efe, H., Sehitoglu, I., Yuce, S. (2015). Topiramate has protective effect on renal injury. Bratislava Medical Journal-Bratislavske Lekarske Listy, 116(4), 259-263. https://doi.org/10.4149/BLL_2015_050 | en_US |
dc.identifier.issn | 0006-9248 | |
dc.identifier.issn | 1336-0345 | |
dc.identifier.uri | https://doi.org/10.4149/BLL_2015_050 | |
dc.identifier.uri | https://hdl.handle.net/11436/2977 | |
dc.description | Cure, Medine Cumhur/0000-0001-9253-6459; cure, erkan/0000-0001-7807-135X | en_US |
dc.description | WOS: 000351975100010 | en_US |
dc.description | PubMed: 25773955 | en_US |
dc.description.abstract | Background: Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-alpha) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage. Methods: A total of 30 male Wistar albino rats were divided into three groups: control, I/R, and I/R plus TPM (I/R+TPM). Laparotomy without I/R injury was performed in control group. After laparotomy, cross ligation of infrarenal abdominal aorta was applied for two hours in I/R groups which was followed by two hours of reperfusion. TPM (100 mg/kg/day) was orally administrated to animals in the I/R+TPM group for seven consecutive days before I/R. Results: the I/R group's TNF-a and interleukin-1 beta (IL-1(3) levels were significantly higher (1184.2 +/- 129.1 pg/mg protein; 413.1 +/- 28.8 pg/mg protein, respectively) than those of the control (907.8 +/- 113.0 pg/mg protein, p = 0.002; 374.7 +/- 23.7 pg/mg protein, p = 0.010, respectively) and I/R+TPM groups (999.5 +/- 115.2 pg/mg protein, p < 0.001; 377.9 +/- 30.9 pg/mg protein, p = 0.007, respectively). Conclusion: TPM may partially prevent renal damage in rats. the opening of new horizons of this kind of knowledge will help understand the complex challenge in the prevention of renal I/R damage (Tab. 1, Fig. 3, Ref. 42). Text in PDF www.elis.sk. | en_US |
dc.description.sponsorship | RTEU Bilimsel Arastirmalar Proje birimi (BAP)Recep Tayyip Erdogan University [2012.106.01.8] | en_US |
dc.description.sponsorship | The authors would like to thank Ayhan Kanat who improved the spelling errors in this article. Source of Support: RTEU Bilimsel Arastirmalar Proje birimi (BAP), Project number: 2012.106.01.8. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Comenius Univ | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Topiramate | en_US |
dc.subject | Ischemia reperfusion | en_US |
dc.subject | Kidney | en_US |
dc.subject | Carbonic anhydrase II | en_US |
dc.title | Topiramate has protective effect on renal injury | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Cüre, Medine Cumhur | |
dc.contributor.institutionauthor | Cüre, Erkan | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Kalkan, Yıldıray | |
dc.contributor.institutionauthor | Aydın, İlkyaz | |
dc.contributor.institutionauthor | Kırbaş, Aynur | |
dc.contributor.institutionauthor | Efe, Hasan | |
dc.contributor.institutionauthor | Şehitoğlu, İbrahim | |
dc.contributor.institutionauthor | Yüce, Süleyman | |
dc.identifier.doi | 10.4149/BLL_2015_050 | |
dc.identifier.volume | 116 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 259 | en_US |
dc.identifier.endpage | 263 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Bratislava Medical Journal-Bratislavske Lekarske Listy | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |