dc.contributor.author | Şahin, Serap Baydur | |
dc.contributor.author | Şahin, Osman Zikrullah | |
dc.contributor.author | Ayaz, Teslime | |
dc.contributor.author | Karadağ, Zakir | |
dc.contributor.author | Türkyılmaz, Kemal | |
dc.contributor.author | Aktaş, Ezgi | |
dc.contributor.author | Bostan, Mehmet | |
dc.date.accessioned | 2020-12-19T19:58:58Z | |
dc.date.available | 2020-12-19T19:58:58Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Sahin, S.B., Sahin, O.Z., Ayaz, T., Karadag, Z., Turkyilmaz, K., Aktas, E., Bostan, M. (2014). The relationship between retinal nerve fiber layer thickness and carotid intima media thickness in patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice, 106(3), 583-589. https://doi.org/10.1016/j.diabres.2014.09.010 | en_US |
dc.identifier.issn | 0168-8227 | |
dc.identifier.issn | 1872-8227 | |
dc.identifier.uri | https://doi.org/10.1016/j.diabres.2014.09.010 | |
dc.identifier.uri | https://hdl.handle.net/11436/3026 | |
dc.description | WOS: 000346060800038 | en_US |
dc.description | PubMed: 25315984 | en_US |
dc.description.abstract | Aims: the aim of the present study was to investigate retinal nerve fiber layer (RNFL) thickness in patients with type 2 diabetes mellitus (T2D) using spectral-domain optical coherence tomography and to evaluate the relationship between RNFL thickness and carotid intima media thickness (CIMT). Methods: This study included 171 patients with T2D (53.2+/-8.8 years) and age matched 61 healthy controls (51.9+/-8.1 years). We evaluated anthropometric and metabolic parameters as well as RNFL and CIMT measurements in patients with T2D and controls. the MannWhitney U test was used to compare the continuous variables and the Chi-square test was used to compare categorical variables. Spearman's rank correlation test was used for calculation of associations between variables. Results: the average RNFL thickness was 84.82+/-11.22 mm in patients with T2D and 92.35+/-8.45 mm in healthy controls (p < 0.001). Mean CIMT values were higher in patients with T2D (0.80+/-0.1 mm) than the healthy subjects (0.72+/-0.1 mm) (p < 0.001). A significant negative correlation was found between age and all quadrants of RNFL. There was a negative correlation between average RNFL thickness and HbA1c (r =-0.176), uric acid (r = -0.145), CIMT (r = -0.190) and presence of carotid plaque (r = -0.193). the superior RNFL thickness was negatively associated with HbA1c (r = -0.175), CIMT (r = -0.207) and carotid plaque (r = -0.176). There was also an inverse correlation between the inferior RNFL thickness and HbA1c (r = -0.187) and carotid plaque (r = -0.157). Conclusion: Thinning of RNFL might be associated with atherosclerosis in patients with T2D. (C) 2014 Elsevier Ireland Ltd. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Ireland Ltd | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Retinal nerve fiber layer thickness | en_US |
dc.subject | Carotid intima media thickness | en_US |
dc.subject | Type 2 diabetes | en_US |
dc.title | The relationship between retinal nerve fiber layer thickness and carotid intima media thickness in patients with type 2 diabetes mellitus | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Şahin, Serap Baydur | |
dc.contributor.institutionauthor | Şahin, Osman Zikrullah | |
dc.contributor.institutionauthor | Ayaz, Teslime | |
dc.contributor.institutionauthor | Karadağ, Zakir | |
dc.contributor.institutionauthor | Türkyılmaz, Kemal | |
dc.contributor.institutionauthor | Aktaş, Ezgi | |
dc.contributor.institutionauthor | Bostan, Mehmet | |
dc.identifier.doi | 10.1016/j.diabres.2014.09.010 | |
dc.identifier.volume | 106 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 583 | en_US |
dc.identifier.endpage | 589 | en_US |
dc.relation.journal | Diabetes Research and Clinical Practice | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |