dc.contributor.author | Dursun, Adile Berna | |
dc.contributor.author | Şahin, Osman Zikrullah | |
dc.date.accessioned | 2020-12-19T20:02:57Z | |
dc.date.available | 2020-12-19T20:02:57Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Dursun, A.B., Sahin, O.Z., (2014).Allopurinol desensitization with A 2 weeks modified protocol in an elderly patients with multiple comorbidities: a case report.Allergy Asthma and Clinical Immunology, 10, 52.
https://doi.org/10.1186/1710-1492-10-52 | |
dc.identifier.issn | 1710-1492 | |
dc.identifier.uri | https://doi.org/10.1186/1710-1492-10-52 | |
dc.identifier.uri | https://hdl.handle.net/11436/3040 | |
dc.description | Dursun, A. Berna/0000-0002-6337-6326 | en_US |
dc.description | WOS: 000346025100001 | en_US |
dc.description | PubMed: 25685161 | en_US |
dc.description.abstract | Background: Allopurinol is an effective urate-lowering drug that is well tolerated by the majority of patients. Patients with chronic renal insufficiency have an increased risk of hypersensitivity reactions with allopurinol. Case presentation: 75 year old male patient with gout, renal insufficiency, history of metastatic colorectal carcinoma status post-resection was referred to Allergy clinic for a maculopapular eruption that developed 1 week after initiating therapy with allopurinol. the rash resolved with discontinuation of allopurinol. However, his serum urate level rose to 19.9 mg/dl. We initially proposed a slow 4 week oral allopurinol desensitization. the treating nephrologist felt it was critical to lower urate more rapidly. As a result, we modified the dose and standard 4 week protocol down to 2 weeks. A suspension of allopurinol was prepared by the allergy nurse practitioner with a 300 mg allopurinol tablet. the sensitization protocol was modified as a starting dose of 0.3 mg escalating to a final dose of 300 mg/day in 2 weeks. There was no reaction during or after the desensitization. the patient's urate level normalized (6.3 mg/dl) and has continued on 300 mg allopurinol daily without reaction. Conclusion: A 2 week modified allopurinol desensitization protocol is a safe alternative for elderly patients with multiple comorbidities. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Bmc | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Allopurinol hypersensitivty | en_US |
dc.subject | Oral drug desensitization | en_US |
dc.subject | Slow desensitization | en_US |
dc.subject | Hyperuricemia | en_US |
dc.subject | Gout | en_US |
dc.subject | Maculopapular exanthema | en_US |
dc.title | Allopurinol desensitization with A 2 weeks modified protocol in an elderly patients with multiple comorbidities: a case report | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Dursun, Adile Berna | |
dc.contributor.institutionauthor | Şahin, Osman Zikrullah | |
dc.identifier.doi | 10.1186/1710-1492-10-52 | |
dc.identifier.volume | 10 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Allergy Asthma and Clinical Immunology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |